EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-03-01
End Date 2024-02-29
Project Code TMA2017GSF-1962
Status Active

Title

EDCTP-GSK fellowship: Cardiometabolic Diseases Risk Evaluation and Reduction in African People Living with HIV Infection

Objectives

The Cardiometabolic Diseases Risk Evaluation and Reduction in African People Living with HIV Infection (CaDERAL) aims to enhance the understanding of common CMDs, and improve their co-detection and co-management in African people living with HIV infection, through a program of research and capacity development based on a network of institutions led by the South African Medical Research Council (SAMRC), and comprising the Nigerian Institute of Medical Research (NIMR), the Clinical Research Education, Networking and Consultancy (CRENC, Cameroon). Specifically we will: 1) Characterise the cardiometabolic profile of adults HIV-infected individuals at their baseline enrolment in Cameroon, using data from the Cameroon arm of the ongoing International Epidemiologic Databases to Evaluate AIDS (IeDEA). 2) Assess the incidence and remission of dyslipidemia and impaired kidney function in people with HIV on ART in Nigeria, using data from the NIMR HIV cohort. 3) Conduct a clinical trial to test the effectiveness of sending weekly SMS-text message in improving health outcomes and supporting medication adherence in South African adults with co-morbid HIV and hypertension. This will be augmented with process evaluation and cost-effectiveness analysis. 4) The three research projects in 1-3 will support the training of a PhD student in each of the three countries, and reinforce the research capacities of junior and senior researchers where appropriate.

Host Organisation

Institution Country
South African Medical Research Council South Africa

Study Design

The core component of the project is a 12-month, individually randomized controlled two-arm trial, open-labelled single blinded, to assess the effect of text messaging vs. usual care on adherence to hypertension medications and outcomes of care among adult South Africans with co-morbid HIV and hypertension. This will be augmented with process evaluation and economic analysis. The trial is based on an adaptation of the StAR trial conducted in the general population in Cape Town. A software algorithm will assigned participants independent of the research team to the intervention and control arms in a 1:1 ratio using a non-deterministic minimization algorithm to ensure balance between groups with respect to key characteristics including gender, age, baseline blood pressure and known duration of hypertension. The treatment group will receive messages to motivate collecting and taking medicine and to provide education about and motivation for secondary adherence, in particular, on healthy lifestyle choices. These messages will be sent three times a week for 52 weeks. Outcome measures will include: Primary – mean difference in SBP and DBP; Secondary – 1) uptake and adherence to BP medications; with adherence measured using the 5 item Medication Adherence Report Scale (MARS) adiminstered at baseline and at the end of the trial;, 2) uptake and adherence to HIV specific medications, 3) mean change in lipid variables, 4) mean change in CD4 count and viral load, 4) mean change in adiposity variables, 5) change in kidney function; Tertiary - 1) Descriptive analysis of the process involved in the intervention, 2) Economic analysis, 3) Quality of life. Using the standard deviation from the baseline work (18 mmHg for SBP)12 and 90% power for a 5mmHg drop in SBP in the intervention as compared to the control arm, 546 participants will be needed per study arm. Allowing for a 20% dropout rate, the total number of participants will be 1300 (650 per arm/site).

Students Supervised

Type Name Title University Start Date End Date
PhD Peter Ebasone Mr University of Cape Town 2020 2024
PhD Odubela Oluwatosin Mr University of Cape Town 2020 2024
PhD Danleen Hongoro Mr University of Cape Town 2020 2024

Publications

Odukoya OO, Ohazurike C, Akanbi M, O'Dwyer LC, Isikekpei B, Kuteyi E, Ameh IO, Osadiaye O, Adebayo K, Usinoma A, Adewole A, Odunukwe N, Okuyemi K, Kengne AP. mHealth Interventions for Treatment Adherence and Outcomes of Care for Cardiometabolic Disease Among Adults Living With HIV: Systematic Review. JMIR Mhealth Uhealth. 2021 Jun 9;9(6):e20330. doi: 10.2196/20330.
Nguyen KA, Peer N, Kengne AP. Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa. PLoS One. 2021 Feb 5;16(2):e0246131. doi: 10.1371/journal.pone.0246131. eCollection 2021.
Peer N, de Villiers A, Jonathan D, Kalombo C, Kengne AP. Care and management of a double burden of chronic diseases: Experiences of patients and perceptions of their healthcare providers. PLoS One. 2020 Jul 16;15(7):e0235710. doi: 10.1371/journal.pone.0235710. eCollection 2020.

Current Organisation

South African Medical Research Council

Current Job Title

Director, Non-Communicable Diseases Research Unit

Students Supervised

Type Name Title University Start Date End Date
PhD Peter Ebasone Mr University of Cape Town 2020 2024
PhD Odubela Oluwatosin Mr University of Cape Town 2020 2024
PhD Danleen Hongoro Mr University of Cape Town 2020 2024

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
,

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Grants

Publications

Authors:
Kengne AP , author
Libend CN , author
Dzudie A , author
Menanga A , author
Dehayem MY , author
Kingue S , author
Sobngwi E , author
Date:
2014-10-01
Journal:
The Pan African medical journal
Content:
Authors:
Pheiffer C , author
Erasmus RT , author
Kengne AP , author
Matsha TE , author
Date:
2015-12-01
Journal:
Clinical biochemistry
Content:
Authors:
Yako YY , author
Madubedube JH , author
Kengne AP , author
Erasmus RT , author
Pillay TS , author
Matsha TE , author
Date:
2015-12-01
Journal:
African health sciences
Content:
Authors:
Kufe NC , author
Masemola M , author
Chikowore T , author
Kengne AP , author
Olsson T , author
Goedecke JH , author
Micklesfield LK , author
Date:
2019-01-01
Journal:
BMJ open
Content:
Authors:
GACD Hypertension Research Programme , author
Writing Group , author
Peiris D , author
Thompson SR , author
Beratarrechea A , author
Cárdenas MK , author
Diez-Canseco F , author
Goudge J , author
Gyamfi J , author
Hypertension Research Programme members , author
Date:
2015-11-01
Journal:
Implementation science : IS
Content:
Authors:
Cindy George , author
Tandi E Matsha , author
Saarah FG Davids , author
Gloudina M Hon , author
U Chikte , author
Rajiv T Erasmus , author
Andre P Kengne , author
Date:
2022-03-08
Journal:
South African Dental Journal
Content:
Authors:
Kaze FF , author
Ashuntantang G , author
Kengne AP , author
Hassan A , author
Halle MP , author
Muna W , author
Date:
2012-04-01
Journal:
Hemodialysis international. International Symposium on Home Hemodialysis
Content:
Authors:
Nouya AY , author
Nansseu JR , author
Moor VJ , author
Pieme CA , author
Noubiap JJ , author
Tchoula CM , author
Mokette BM , author
Takam RD , author
Tankeu F , author
Ngogang JY , author
Kengne AP , author
Date:
2014-10-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
Kengne AP , author
Dzudie A , author
Dongmo L , author
Date:
2006-10-01
Journal:
Neuroepidemiology
Content:
Authors:
Mazidi M , author
Heidari-Bakavoli A , author
Khayyatzadeh SS , author
Azarpazhooh MR , author
Nematy M , author
Safarian M , author
Esmaeili H , author
Parizadeh SM , author
Ghayour-Mobarhan M , author
Kengne AP , author
Ferns GA , author
Date:
2016-09-01
Journal:
European journal of clinical nutrition
Content:
Authors:
Werfalli M , author
Raubenheimer PJ , author
Engel M , author
Musekiwa A , author
Bobrow K , author
Peer N , author
Hoegfeldt C , author
Kalula S , author
Kengne AP , author
Levitt NS , author
Date:
2020-06-01
Journal:
Systematic reviews
Content:
Authors:
Andre Pascal Kengne , author
Eugene Sobngwi , author
Leopold Fezeu , author
Paschal Kum Awah , author
Sylvestre Dongmo , author
Date:
Journal:
Content:
Setting-up nurse-led pilot clinics for the management of non-communicable diseases at primary health care level in resource-limited settings of Africa
Authors:
Nong-Libend C , author
Menanga AP , author
Kengne AP , author
Dehayem M , author
Sobngwi E , author
Kingue S , author
Date:
2012-05-01
Journal:
Diabetes & metabolism
Content:
Authors:
Echouffo-Tcheugui JB , author
Kengne AP , author
Ali MK , author
Date:
2018-09-01
Journal:
Current diabetes reports
Content:
Authors:
Kaze FF , author
Meto DT , author
Halle MP , author
Ngogang J , author
Kengne AP , author
Date:
2015-07-01
Journal:
BMC nephrology
Content:
Authors:
Theodosia Adom , author
Anniza De Villiers , author
Thandi Puoane , author
André Pascal Kengne , author
Date:
2019-01-01
Journal:
Content:
Abstract Background There is limited data on risk factors associated with childhood overweight and obesity in Ghanaian school children. Therefore, the aim of this study was to assess the prevalence of overweight and obesity and associated risk factors in Ghanaian school children. Methods Data for this study were obtained from a cross-sectional survey of 543 children aged 8 and 11 years, attending private and public primary schools in the Adentan Municipality of Greater Accra Region, Ghana. Anthropometric, dietary, physical activity, sedentary behaviours, sleep duration and socio-demographic data were collected. BMI-for-age Z-scores were used to classify children as overweight/obesity. Multivariable logistic regressions were used to assess the determinants of overweight and obesity. Results The overall prevalence of overweight/obesity was 16.4%. Children living in middle (OR = 1.88; 95% CI = 1.01–3.50) and high socioeconomic status (SES) households (2.58; 1.41–4.70) had increased odds of being overweight or obese compared to those living in low SES household. Attending private school (2.44; 1.39–4.29) and watching television for more than 2 h each day (1.72; 1.05–2.82) were significantly associated with increased likelihood of overweight and obesity. Children who slept for more than 9 h a night (0.53; 0.31–0.88) and walked or cycled to school (0.51; 0.31–0.82) had lower odds of being overweight or obese. Conclusions A number of modifiable risk factors were associated with overweight and obesity in this study. Public health strategies to prevent childhood obesity should target reduction in television watching time, promoting active transport to and from school, and increasing sleep duration.
Authors:
Mbanya V , author
Hussain A , author
Kengne AP , author
Date:
2015-05-01
Journal:
Primary care diabetes
Content:
Authors:
Pule GD , author
Ngo Bitoungui VJ , author
Chetcha Chemegni B , author
Kengne AP , author
Wonkam A , author
Date:
2016-11-01
Journal:
Hemoglobin
Content:
Authors:
Feigin VL , author
Krishnamurthi RV , author
Parmar P , author
Norrving B , author
Mensah GA , author
Bennett DA , author
Barker-Collo S , author
Moran AE , author
Sacco RL , author
Truelsen T , author
Davis S , author
Pandian JD , author
GBD 2013 Stroke Panel Experts Group , author
Date:
2015-10-01
Journal:
Neuroepidemiology
Content:
Authors:
Kengne AP , author
Sobngwi E , author
Echouffo-Tcheugui JB , author
Mbanya JC , author
Date:
2013-05-01
Journal:
Heart (British Cardiac Society)
Content:
Authors:
Mazidi M , author
Kengne AP , author
Sahebkar A , author
Banach M , author
Date:
2017-06-01
Journal:
Angiology
Content:
Authors:
Date:
2005-10-28
Journal:
International journal of epidemiology
Content:
BACKGROUND: As the relation between socioeconomic status (SES) and obesity may depend on the stage of development of a country, this relation is assessed in adults from urban Cameroon. METHODS: A sample comprising 1530 women and 1301 men aged 25 years and above, from 1897 households in the Biyem-Assi health area in the capital of Cameroon, Yaoundé, were interviewed about their household amenities, occupation, and education. Weight, height, and waist circumference were measured and subjects were classified as obese if their BMI>or=30 kg/m2 or overweight if BMI was between 25.0 and 29.9 kg/m2. Abdominal obesity was defined by a waist circumference>or=80 cm in women and>or=94 cm in men. RESULTS: Of the sample studied 33% of women and 30% of men were overweight (P<0.08), whereas 22% of women and 7% of men were obese (P<0.001). Abdominal obesity was present in 67% of women and 18% of men (P<0.001). After adjusting for age, leisure time physical activity, alcohol consumption, and tobacco smoking, the prevalence of overweight+obesity, obesity, and abdominal obesity increased with quartiles of household amenities in both genders and with occupational level in men. CONCLUSION: SES is positively associated with adiposity in urban Cameroon after adjusting for confounding factors.
Authors:
Marie Patrice Halle , author
Gloria Ashuntantang , author
Francois Folefack Kaze , author
Christian Takongue , author
Andre-Pascal Kengne , author
Date:
2016-12-01
Journal:
BMC Nephrology
Content:
Authors:
Boateng D , author
Agyemang C , author
Beune E , author
Meeks K , author
Smeeth L , author
Schulze M , author
Addo J , author
de-Graft Aikins A , author
Galbete C , author
Bahendeka S , author
Danquah I , author
Agyei-Baffour P , author
Klipstein-Grobusch K , author
Date:
2017-11-01
Journal:
Circulation. Cardiovascular quality and outcomes
Content:
Authors:
Matsha TE , author
Hartnick MD , author
Kisten Y , author
Eramus RT , author
Kengne AP , author
Date:
2013-10-01
Journal:
Journal of diabetes
Content:
Authors:
Mazidi M , author
Kengne AP , author
George ES , author
Siervo M , author
Date:
2019-08-01
Journal:
The British journal of nutrition
Content:
Authors:
Katte JC , author
Dzudie A , author
Sobngwi E , author
Mbong EN , author
Fetse GT , author
Kouam CK , author
Kengne AP , author
Date:
2014-07-01
Journal:
BMC public health
Content:
Authors:
Alain Lekoubou , author
Clovis Nkoke , author
Anastase Dudzie , author
Andre Pascal Kengne , author
Date:
2016-01-01
Journal:
Content:
Background: Despite the increasing availability of head computerized tomography (CT) in resource-limited settings, it is unclear if brain-imaging-based diagnosis of stroke affects the outcomes in the absence of dedicated structures for acute stroke management. Objectives: In a major referral hospital in the capital city of Cameroon, we compared in-hospital mortality rates in patients with a WHO-based diagnosis of stroke between participants with and without brain imaging on admission. Methods: Stroke patients with and without admission brain imaging were compared for demographic characteristics, risk factors, clinical and laboratory characteristic, and in-hospital mortality. Heterogeneities in mortality rates (CT vs. No CT) across major subgroups were investigated via interaction tests, and logistic regressions used to adjust for extraneous factors such as age, sex, year of study, residency, history of diabetes and hypertension, history of stroke, Glasgow coma scale, and delay between stroke symptoms onset and hospital admission. Results: Of the 1688 participants included in the final analysis, 1048 (62.1%) had brain imaging. The median age of the non-CT vs. CT groups was 65 vs. 62 years (p-value < 0.0001%). The death rate of non-CT vs. CT groups was 27.5% vs. 16.4% (p < 0.0001). This difference was mostly similar across major subgroups, and robust to the adjustments for confounders (in spite of substantial attenuation), with excess deaths in those with CT ranging from 65% to 149%. Conclusion: In this resource-limited environment, the absence of brain imaging on admission was associated with high in-hospital death from stroke, which was only partially explained by delayed hospitalization with severe disease. These results stressed the importance of scaling up acute stroke management in low- and middle-income countries.
Authors:
Pefura Yone EW , author
Kuaban C , author
Kengne AP , author
Date:
2012-08-01
Journal:
BMC infectious diseases
Content:
Authors:
Zemlin AE , author
Matsha TE , author
Kengne AP , author
Hon GM , author
Erasmus RT , author
Date:
2016-09-01
Journal:
Annals of clinical biochemistry
Content:
Authors:
Engel ME , author
Cohen K , author
Gounden R , author
Kengne AP , author
Barth DD , author
Whitelaw AC , author
Francis V , author
Badri M , author
Stewart A , author
Dale JB , author
Mayosi BM , author
Maartens G , author
Date:
2017-03-01
Journal:
The Pediatric infectious disease journal
Content:
Authors:
GBD 2017 Inflammatory Bowel Disease Collaborators , author
Date:
2019-10-01
Journal:
The lancet. Gastroenterology & hepatology
Content:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
Hassan Vatanparast , author
Date:
2017-01-01
Journal:
Oxidative Medicine and Cellular Longevity
Content:
Authors:
Uthman OA , author
Nduka C , author
Watson SI , author
Mills EJ , author
Kengne AP , author
Jaffar SS , author
Clarke A , author
Moradi T , author
Ekström AM , author
Lilford R , author
Date:
2018-06-01
Journal:
BMC infectious diseases
Content:
Authors:
NCD Risk Factor Collaboration (NCD-RisC) , author
Date:
2019-05-01
Journal:
Nature
Content:
Authors:
Steve Raoul Ngongang Noumegni , author
Jobert Richie Nansseu , author
Vicky Jocelyne Moor Ama , author
Jean Joel Bigna , author
Felix Kembe Assah , author
Magellan Guewo-Fokeng , author
Steve Leumi , author
Jean-Claude Katte , author
Mesmin Dehayem , author
Andre Pascal Kengne , author
Eugene Sobngwi , author
Date:
2017-01-01
Journal:
Content:
Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. Results We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10–4.72). Conclusion Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.
Authors:
Andre Pascal Kengne , author
Anushka Patel , author
Date:
2006-01-01
Journal:
Content:
Authors:
Kuguyo O , author
Kengne AP , author
Dandara C , author
Date:
2020-06-01
Journal:
Omics : a journal of integrative biology
Content:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
Dimitri P. Mikhailidis , author
Arrigo F. Cicero , author
Maciej Banach , author
Date:
2017-01-01
Journal:
Content:
Abstract ; Background and aim: Growing evidence suggests that some of the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed the relationship between selected dietary constituents and serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of United States adults. Methods: In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010. All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). Results: Of the 17,689 participants analysed, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample, 44.9 in men and 46.5 in women ( p = .047). The age-, race-, sex-, energy intake- and body mass index-adjusted mean dietary intakes of total dietary fibre, polyunsaturated fatty-acids, vitamin E, vitamin A, vitamin B6, total folate, vitamin B family, vitamin C, vitamin K, magnesium, iron, copper and potassium monotonically decreased across increasing hsCRP quarters ( p < .001 for all), whereas sugar intake increased ( p < .001). In analysis of covariance adjusted for potential confounders (age-, race-, sex-, energy intake- and body weight-) hsCRP levels increased across increasing quarters of sugar intake ( p < .001). Conclusions: This study provides further evidence of an association between dietary sugar, polyunsaturated fatty-acids, fibre and antioxidant intake and hsCRP levels, a subclinical inflammation marker. hsCRP concentrations are likely modulated by dietary intake.KEY MESSAGES Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake. Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake.
Authors:
Dzudie A , author
Rayner B , author
Ojji D , author
Schutte AE , author
Twagirumukiza M , author
Damasceno A , author
Ba SA , author
Kane A , author
Kramoh E , author
Anzouan Kacou JB , author
Onwubere B , author
Cornick R , author
Sliwa K , author
PASCAR Task Force on Hypertension , author
Date:
2017-10-01
Journal:
Global heart
Content:
Authors:
Balti EV , author
Kengne AP , author
Fokouo JVF , author
Nouthé BE , author
Sobngwi E , author
Date:
2013-12-01
Journal:
PloS one
Content:
Authors:
Chalmers J , author
Kengne AP , author
Joshi R , author
Perkovic V , author
Patel A , author
Date:
2007-06-01
Journal:
Journal of hypertension. Supplement : official journal of the International Society of Hypertension
Content:
Authors:
Kim Anh Nguyen , author
Naeemah Abrahams , author
Rachel Jewkes , author
Shibe Mhlongo , author
Soraya Seedat , author
Bronwyn Myers , author
Carl Lombard , author
Claudia Garcia-Moreno , author
Esnat Chirwa , author
Andre Pascal Kengne , author
Nasheeta Peer , author
Date:
2022-03-29
Journal:
International Journal of Environmental Research and Public Health
Content:
Authors:
Moloi MW , author
Kajawo S , author
Noubiap JJ , author
Mbah IO , author
Ekrikpo U , author
Kengne AP , author
Bello AK , author
Okpechi IG , author
Date:
2018-05-01
Journal:
BMJ open
Content:
Authors:
Lekoubou A , author
Philippeau F , author
Derex L , author
Olaru A , author
Gouttard M , author
Vieillart A , author
Kengne AP , author
Date:
2013-12-01
Journal:
Neurological research
Content:
Authors:
Matsha TE , author
Hassan MS , author
Hon GM , author
Soita DJ , author
Kengne AP , author
Erasmus RT , author
Date:
2013-05-01
Journal:
International journal of cardiology
Content:
Authors:
Matsha TE , author
Kengne AP , author
Masconi KL , author
Yako YY , author
Erasmus RT , author
Date:
2015-06-01
Journal:
BMC genetics
Content:
Authors:
Matsha TE , author
Yako YY , author
Rensburg MA , author
Hassan MS , author
Kengne AP , author
Erasmus RT , author
Date:
2013-04-01
Journal:
BMC nephrology
Content:
Authors:
Mazidi M , author
Shivappa N , author
Wirth MD , author
Hebert JR , author
Kengne AP , author
Date:
2018-11-01
Journal:
European journal of clinical nutrition
Content:
Authors:
Eric Walter Pefura-Yone , author
André Pascal Kengne , author
Emmanuel Afane-Ze , author
Christopher Kuaban , author
Date:
Journal:
Content:
Background German cockroach or Blattella germanica is commonly found in homes across the inter-tropical region. The contribution of sensitisation to Blattella germanica in people with asthma in sub-Saharan Africa has not received attention. The aim of this study was to assess the prevalence and investigate the predicting factors of sensitisation to Blattella germanica in patients with asthma in Yaounde, Cameroon.Methods This was a cross-sectional study conducted between January 2012 and June 2013. All patients (aged 15 years and above) with asthma, receiving care at the Yaounde Jamot Hospital and the CEDIMER medical practice during the study period and who had received a prick skin testing for perennial aeroallergens were included in the study.Results The final sample comprised 184 patients including 123 (66.8%) women. The median age (25th-75th percentiles) was 38 (24–54) years. Prick skin test for Blattella germanica was positive in 47 (25.5%) patients. Sensitisation to Blattella germanica was associated with a sensitisation to mite in 41 (87.2%) patients, a sensitisation to Alternaria in 18 (38.3%) patients, and a sensitisation to cat or dog dander in 7 (14.9%) patients. Independent predicting factors of a sensitisation to Blattella germanica were the sensitisation to Blomia tropicalis [adjusted odd ratio (95% confidence interval) 4.10 (1.67-10.04), p = 0.002] and sensitisation to Alternaria [3.67 (1.53-7.46), p = 0.003].Conclusions Sensitisation to Blattella germanica is present in about a quarter of adult patients with asthma in Yaounde. Sensitisation to Alternaria and Blomia tropicalis appears to be a powerful predicting factor of sensitisation to Blattella germanica in this setting. Keywords: Asthma, Blattella, Allergy, Aeroallergens, Africa
Authors:
Eric Walter Pefura-Yone , author
Emmanuel Soh , author
André Pascal Kengne , author
Adamou Dodo Balkissou , author
Christopher Kuaban , author
Date:
2013-01-01
Journal:
Content:
Summary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31–0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14–2.28)], Pentecostal Christianity [2.18 (1.25–3.80)], alcohol consumption [1.65 (1.16–2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92–8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19–2.12)], [1.83 (1.36–2.47)], [1.70 (1.27–2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17–2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. Keywords: Antiretroviral therapy, Adherence, HIV infection, Cameroon
Authors:
Riddell MA , author
Edwards N , author
Thompson SR , author
Bernabe-Ortiz A , author
Praveen D , author
Johnson C , author
Kengne AP , author
Liu P , author
McCready T , author
Ng E , author
Nieuwlaat R , author
Ovbiagele B , author
Owolabi M , author
GACD Hypertension Research Programme , author
Date:
2017-03-01
Journal:
Globalization and health
Content:
Authors:
GBD 2017 Gastro-oesophageal Reflux Disease Collaborators , author
Date:
2020-03-01
Journal:
The lancet. Gastroenterology & hepatology
Content:
Authors:
Ataklte F , author
Erqou S , author
Kaptoge S , author
Taye B , author
Echouffo-Tcheugui JB , author
Kengne AP , author
Date:
2014-11-01
Journal:
Hypertension (Dallas, Tex. : 1979)
Content:
Authors:
Wang H , author
Liddell CA , author
Coates MM , author
Mooney MD , author
Levitz CE , author
Schumacher AE , author
Apfel H , author
Iannarone M , author
Phillips B , author
Lofgren KT , author
Sandar L , author
Dorrington RE , author
Rakovac I , author
Murray CJ , author
Date:
2014-05-01
Journal:
Lancet (London, England)
Content:
Authors:
Odukoya OO , author
Ohazurike C , author
Akanbi M , author
O'Dwyer LC , author
Isikekpei B , author
Kuteyi E , author
Ameh IO , author
Osadiaye O , author
Adebayo K , author
Usinoma A , author
Adewole A , author
Odunukwe N , author
Okuyemi K , author
Kengne AP , author
Date:
2021-06-01
Journal:
JMIR mHealth and uHealth
Content:
Authors:
Kaze FF , author
Kengne AP , author
Atanga LC , author
Monny Lobe M , author
Menanga AP , author
Halle MP , author
Chetcha Chemegni B , author
Ngo Sack F , author
Kingue S , author
Ashuntantang G , author
Date:
2012-10-01
Journal:
Clinical kidney journal
Content:
Authors:
GBD 2020 , author
Release 1 , author
Vaccine Coverage Collaborators , author
Date:
2021-07-01
Journal:
Lancet (London, England)
Content:
Authors:
Fezeu LK , author
Assah FK , author
Balkau B , author
Mbanya DS , author
Kengne AP , author
Awah PK , author
Mbanya JC , author
Date:
2008-03-01
Journal:
Obesity (Silver Spring, Md.)
Content:
Authors:
Kengne AP , author
Dzudie AI , author
Fezeu LL , author
Mbanya JC , author
Date:
2006-03-01
Journal:
The international journal of lower extremity wounds
Content:
Authors:
Kengne AP , author
Awah PK , author
Fezeu L , author
Mbanya JC , author
Date:
2007-03-01
Journal:
African health sciences
Content:
Authors:
Vergotine Z , author
Kengne AP , author
Erasmus RT , author
Yako YY , author
Matsha TE , author
Date:
2014-08-01
Journal:
International journal of endocrinology
Content:
Authors:
Aminde LN , author
Takah NF , author
Noubiap JJ , author
Tindong M , author
Ngwasiri C , author
Jingi AM , author
Kengne AP , author
Dzudie A , author
Date:
2015-11-01
Journal:
BMC public health
Content:
Authors:
Moons KG , author
Kengne AP , author
Woodward M , author
Royston P , author
Vergouwe Y , author
Altman DG , author
Grobbee DE , author
Date:
2012-03-01
Journal:
Heart (British Cardiac Society)
Content:
Authors:
van Dieren S , author
Kengne AP , author
Chalmers J , author
Beulens JW , author
Cooper ME , author
Grobbee DE , author
Harrap S , author
Mancia G , author
Neal B , author
Patel A , author
Poulter N , author
van der Schouw YT , author
Woodward M , author
Zoungas S , author
Date:
2012-06-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators , author
Date:
2018-11-01
Journal:
The Lancet. Neurology
Content:
Authors:
Eric Vounsia Balti , author
André Pascal Kengne , author
Jean Valentin Fogha Fokouo , author
Brice Enid Nouthé , author
Eugene Sobngwi , author
Date:
Journal:
Content:
BACKGROUND AND PURPOSE: Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa). METHODS: Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment. RESULTS: Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p≤0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p = 0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p = 0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset. CONCLUSION: The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.
Authors:
Carmen Pheiffer , author
Victoria Pillay-van Wyk , author
Eunice Turawa , author
Naomi Levitt , author
Andre P. Kengne , author
Debbie Bradshaw , author
Date:
2021-05-30
Journal:
International Journal of Environmental Research and Public Health
Content:
Authors:
Di Cesare M , author
Sorić M , author
Bovet P , author
Miranda JJ , author
Bhutta Z , author
Stevens GA , author
Laxmaiah A , author
Kengne AP , author
Bentham J , author
Date:
2019-11-01
Journal:
BMC medicine
Content:
Authors:
Muyunda Mutemwa , author
Nasheeta Peer , author
Anniza De Villiers , author
Mieke Faber , author
Andre-Pascal Kengne , author
Date:
2020-04-21
Journal:
Southern African Journal of HIV Medicine
Content:
Authors:
Peer N , author
Naicker A , author
Khan M , author
Kengne AP , author
Date:
2020-07-01
Journal:
SAGE open medicine
Content:
Authors:
Anastase, Dzudie , author
Suiru, Dzekem , author
Andre, Pascal Kengne , author
Date:
2017-01-01
Journal:
Content:
Authors:
Macharia M , author
Kengne AP , author
Blackhurst DM , author
Erasmus RT , author
Matsha TE , author
Date:
2013-07-01
Journal:
Journal of clinical pathology
Content:
Authors:
NCD Risk Factor Collaboration (NCD-RisC) , author
Date:
2020-06-01
Journal:
Nature
Content:
Authors:
Kuate-Tegueu C , author
Temfack E , author
Ngankou S , author
Doumbe J , author
Djientcheu VP , author
Kengne AP , author
Date:
2015-05-01
Journal:
Journal of the neurological sciences
Content:
Authors:
Davidson FE , author
Matsha TE , author
Erasmus RT , author
Ismail S , author
Kengne AP , author
Goedecke JH , author
Date:
2020-04-01
Journal:
European journal of clinical nutrition
Content:
Authors:
Davids SF , author
Matsha TE , author
Peer N , author
Erasmus RT , author
Kengne AP , author
Date:
2019-11-01
Journal:
Frontiers in endocrinology
Content:
Authors:
Kuate D , author
Kengne AP , author
Biapa CP , author
Azantsa BG , author
Abdul Manan Bin Wan Muda W , author
Date:
2015-05-01
Journal:
Lipids in health and disease
Content:
Authors:
Kengne AP , author
Czernichow S , author
Huxley R , author
Grobbee D , author
Woodward M , author
Neal B , author
Zoungas S , author
Cooper M , author
Glasziou P , author
Hamet P , author
Harrap SB , author
Mancia G , author
Poulter N , author
ADVANCE Collaborative Group , author
Date:
2009-05-01
Journal:
Hypertension (Dallas, Tex. : 1979)
Content:
Authors:
Davidson FE , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Goedecke JH , author
Date:
2019-11-01
Journal:
Diabetology & metabolic syndrome
Content:
Authors:
Peprah E , author
Armstrong-Hough M , author
Cook S , author
Mukasa B , author
Taylor J , author
Xu H , author
Chang L , author
Gyamfi J , author
Ryan N , author
Ojo T , author
Snyder A , author
Iwelunmor J , author
Ezechi O , author
Iyegbe C , author
Pascal Kengne A , author
Date:
2021-03-01
Journal:
International journal of environmental research and public health
Content:
Authors:
Kengne AP , author
Dzudie A , author
Sobngwi E , author
Date:
2008-01-01
Journal:
Vascular health and risk management
Content:
Authors:
Yone EW , author
Balkissou AD , author
Kengne AP , author
Kuaban C , author
Date:
2012-08-01
Journal:
BMC pulmonary medicine
Content:
Authors:
Adom T , author
Puoane T , author
De Villiers A , author
Kengne AP , author
Date:
2017-02-01
Journal:
BMJ open
Content:
Authors:
Gary Maartens , author
Annemie Stewart , author
Rulan Griesel , author
Andre P. Kengne , author
Felix Dube , author
Mark Nicol , author
Molebogeng X. Rangaka , author
Marc Mendelson , author
Date:
2018-07-23
Journal:
Southern African Journal of HIV Medicine
Content:
Authors:
Masoud M , author
Kengne AP , author
Erasmus RT , author
Hon GM , author
Macharia M , author
Matsha TE , author
Date:
2018-03-01
Journal:
Indian journal of clinical biochemistry : IJCB
Content:
Authors:
Dzudie A , author
Choukem SP , author
Dehayem MY , author
Kengne AP , author
Date:
2012-12-01
Journal:
Journal of diabetes
Content:
Authors:
Thomas B , author
Matsushita K , author
Abate KH , author
Al-Aly Z , author
Ärnlöv J , author
Asayama K , author
Atkins R , author
Badawi A , author
Ballew SH , author
Banerjee A , author
Barregård L , author
Barrett-Connor E , author
Basu S , author
Global Burden of Disease Genitourinary Expert Group , author
Date:
2017-04-01
Journal:
Journal of the American Society of Nephrology : JASN
Content:
Authors:
Kengne AP , author
Awah PK , author
Date:
2009-01-01
Journal:
QJM : monthly journal of the Association of Physicians
Content:
Authors:
Jillian Hill , author
Camille Lavigne Delville , author
Anne-Marie Auorousseau , author
Deborah Jonathan , author
Nasheeta Peer , author
Brian Oldenburg , author
Andre-Pascal Kengne , author
Date:
2020-01-30
Journal:
International Journal of Environmental Research and Public Health
Content:
Authors:
Mhandire D , author
Mhandire K , author
Magadze M , author
Wonkam A , author
Kengne AP , author
Dandara C , author
Date:
2020-05-01
Journal:
Content:
Authors:
Malambo P , author
Kengne AP , author
Lambert EV , author
De Villiers A , author
Puoane T , author
Date:
2017-10-01
Journal:
Journal of physical activity & health
Content:
Authors:
Kaze FF , author
Kengne AP , author
Magatsing CT , author
Halle MP , author
Yiagnigni E , author
Ngu KB , author
Date:
2016-01-01
Journal:
Journal of clinical hypertension (Greenwich, Conn.)
Content:
Authors:
Kaze FF , author
Kengne AP , author
Choukem SP , author
Dzudie A , author
Halle MP , author
Dehayem MY , author
Ashuntantang G , author
Date:
2008-06-01
Journal:
American journal of kidney diseases : the official journal of the National Kidney Foundation
Content:
Authors:
Mazidi M , author
Ofori-Asenso R , author
Kengne AP , author
Date:
2020-05-01
Journal:
Journal of gastroenterology and hepatology
Content:
Authors:
Nkoke C , author
Balti E , author
Menanga A , author
Dzudie A , author
Lekoubou A , author
Kingue S , author
Kengne AP , author
Date:
2017-01-01
Journal:
Translational pediatrics
Content:
Authors:
ADVANCE Collaborative Group , author
Patel A , author
MacMahon S , author
Chalmers J , author
Neal B , author
Billot L , author
Woodward M , author
Marre M , author
Cooper M , author
Glasziou P , author
Grobbee D , author
Hamet P , author
Travert F , author
Date:
2008-06-01
Journal:
The New England journal of medicine
Content:
Authors:
Ngwa EN , author
Kengne AP , author
Tiedeu-Atogho B , author
Mofo-Mato EP , author
Sobngwi E , author
Date:
2015-04-01
Journal:
Diabetology & metabolic syndrome
Content:
Authors:
George C , author
Matsha TE , author
Korf M , author
Zemlin AE , author
Erasmus RT , author
Kengne AP , author
Date:
2020-01-01
Journal:
BMC nephrology
Content:
Authors:
Lekoubou A , author
Clovis N , author
Dzudie A , author
Kengne AP , author
Date:
2016-07-01
Journal:
Primary care diabetes
Content:
Authors:
Olalekan A Uthman , author
Chidozie U Nduka , author
Mustapha Abba , author
Rocio Enriquez , author
Helena Nordenstedt , author
Fred Nalugoda , author
Andre P Kengne , author
Anna M Ekström , author
Date:
2017-11-16
Journal:
Content:
Authors:
Andre Pascal Kengne , author
Sébastien Czernichow , author
Mark Hamer , author
G David Batty , author
Emmanuel Stamatakis , author
Date:
Journal:
Content:
Both anaemia and cardiovascular disease (CVD) are common in people with diabetes. While individually both characteristics are known to raise mortality risk, their combined influence has yet to be quantified. In this pooling project, we examined the combined impact of baseline haemoglobin levels and existing CVD on all-cause and CVD mortality in people with diabetes. We draw comparison of these effects with those apparent in diabetes-free individuals.A combined analyses of 7 UK population-based cohorts resulted in 26,480 study members. There were 946 participants with physician-diagnosed diabetes, 2227 with anaemia [haemoglobin<13 g/dl (men) or <12 (women)], 2592 with existing CVD (stroke, ischaemic heart disease), and 21,396 with none of the conditions. Across diabetes and anaemia subgroups, and using diabetes-free, non-anaemic participants as the referent group, the adjusted hazard ratios (HR) were 1.46 (95% CI: 1.30-1.63) for anaemia, 1.67 (1.45-1.92) for diabetes, and 2.10 (1.55-2.85) for diabetes and anaemia combined. Across combined diabetes, anaemia and CVD subgroups, and compared with non-anaemic, diabetes-free and CVD-free participants, HR (95% CI) for all-cause mortality were 1.49 (1.32-1.69) anaemia, 1.60 (1.46-1.76) for existing CVD, and 1.66 (1.39-1.97) for diabetes alone. Equivalents were 2.13 (1.48-3.07) for anaemia and diabetes, 2.68 (2.14-3.36) for diabetes and existing CVD, and 3.25 (1.88-5.62) for the three combined. Patterns were similar for CVD mortality.Individually, anaemia and CVD confer similar mortality risks in people with diabetes, and are excessively fatal in combination. Screening for anaemia would identify vulnerable diabetic patients whose outcomes can potentially be improved.
Authors:
Mazidi M , author
Kengne AP , author
Date:
2018-08-01
Journal:
Clinical nutrition (Edinburgh, Scotland)
Content:
Authors:
Cecil J. Weale , author
Glenda M. Davison , author
Gloudina M. Hon , author
Andre P. Kengne , author
Rajiv T. Erasmus , author
Tandi E. Matsha , author
Date:
2019-05-16
Journal:
Cells
Content:
Authors:
Eric Walter , author
Pefura Yone , author
Awa Foueudjeu Betyoumin , author
André Pascal Kengne , author
François Jérome , author
Kaze Folefack , author
Jeanne Ngogang , author
Date:
Journal:
Content:
First-line antiretroviral therapy and dyslipidemia in people living with HIV-1 in Cameroon: a cross-sectional study
Authors:
Dzudie A , author
Aminde L , author
Ngowe Ngowe M , author
Takah N , author
Luma HN , author
Doualla MS , author
Mapoure Y , author
Mbatchou H , author
Njamen TN , author
Priso EB , author
Kengne AP , author
Sliwa-Hahnle K , author
Nkwescheu AS , author
Sone AM , author
Date:
2014-09-01
Journal:
Cardiovascular journal of Africa
Content:
Authors:
Mazidi M , author
Kengne AP , author
Date:
2017-03-01
Journal:
European journal of clinical investigation
Content:
Authors:
Kaze AD , author
Schutte AE , author
Erqou S , author
Kengne AP , author
Echouffo-Tcheugui JB , author
Date:
2017-07-01
Journal:
Journal of hypertension
Content:
Authors:
Echouffo-Tcheugui JB , author
Sobngwi E , author
Kengne AP , author
Date:
2012-03-01
Journal:
Archives of internal medicine
Content:
Authors:
NCD Countdown 2030 collaborators , author
Date:
2018-09-01
Journal:
Lancet (London, England)
Content:
Authors:
Choukem SP , author
Sih C , author
Ntumsi AT , author
Dimala CA , author
Mboue-Djieka Y , author
Ngouadjeu EDT , author
Kengne AP , author
Date:
2020-03-01
Journal:
BMC cardiovascular disorders
Content:
Authors:
Kaze FF , author
Njukeng FA , author
Kengne AP , author
Ashuntantang G , author
Mbu R , author
Halle MP , author
Asonganyi T , author
Date:
2014-04-01
Journal:
BMC pregnancy and childbirth
Content:
Authors:
Steve Raoul Noumegni , author
Jobert Richie Nansseu , author
Jean Joel Bigna , author
Vicky Jocelyne Ama Moor , author
Felix Kembe Assah , author
Mesmin Y Dehayem , author
Andre Pascal Kengne , author
Eugene Sobngwi , author
Date:
2017-01-01
Journal:
Content:
Background The paucity of data regarding the association between atherogenic index of plasma and risk of cardiovascular disease in HIV-infected populations living in sub-Saharan Africa prompted us to conduct this study which aimed to assess the relationship between atherogenic index of plasma and risk of cardiovascular disease among a Cameroonian HIV-infected population. Methods This was a cross-sectional study conducted among 452 HIV-infected adults in Yaoundé, Cameroon. Risk of cardiovascular disease was calculated using the Framingham risk score; atherogenic index of plasma was derived as log (triglycerides/high-density lipoproteins cholesterol). Results Participants’ mean age (80% females) was 44.4 ± 9.8 years. Atherogenic index of plasma values ranged from –0.63 to 1.36 with a median of 0.11 (25th–75th percentiles: –0.08-0.31). Most participants (88.5%) were on antiretroviral treatment. There was a significant correlation between atherogenic index of plasma and fasting plasma glucose (r = 0.116; p = 0.014), atherogenic index of plasma and total cholesterol (r = –0.164; p < 0.001). Atherogenic index of plasma was significantly associated with the risk of cardiovascular disease either in univariable (β = 5.05, 95% CI: 3.31–6.79; p < 0.001, R 2 = 0.067) or in multivariable linear regression model after adjusting for socio-demographic, clinical and biological confounders (adjusted β = 3.79, 95% CI: 1.65 – 4.88; p < 0.001, R 2 = 0.187). Conclusion Atherogenic index of plasma may be an independent factor impacting the risk of cardiovascular disease among Cameroonian HIV-infected people. More studies are needed to better elucidate the association between atherogenic index of plasma and risk of cardiovascular disease in our setting.
Authors:
GBD 2013 Mortality and Causes of Death Collaborators , author
Date:
2014-12-01
Journal:
Lancet (London, England)
Content:
Authors:
Moons KG , author
Kengne AP , author
Grobbee DE , author
Royston P , author
Vergouwe Y , author
Altman DG , author
Woodward M , author
Date:
2012-03-01
Journal:
Heart (British Cardiac Society)
Content:
Authors:
Andre Pascal Kengne , author
Anastase Dzudie , author
Eugene Sobngwi , author
Date:
2008-01-01
Journal:
Content:
Andre Pascal Kengne1, Anastase Dzudie2, Eugene Sobngwi31The George Institute for International Health, University of Sydney, Australia; 2Heart failure and transplantation Unit, Louis Pradel’s Cardiovascular Hospital, Lyon, France; 3National Obesity Centre, Yaounde Central Hospital, CameroonPurpose: Heart failure is the ultimate complication of cardiac involvements in diabetes. The purpose of this review was to summarize current literature on heart failure among people with diabetes mellitus in sub-Saharan Africa (SSA).Method: Bibliographic search of published data on heart failure and diabetes in sub-Saharan Africa over the past 26 years.Results: Heart failure remains largely unexplored in general population and among people with diabetes in Africa. Heart failure accounts for over 30% of hospital admission in specialized cardiovascular units and 3%–7% in general internal medicine. Over 11% of adults with heart failure have diabetes. Risk factors for heart failure among those with diabetes include classical cardiovascular risk factors, without evidence of diabetes distinctiveness for other predictors common in Africa. Prevention, management, and outcomes of heart failure are less well known; recent data suggest improvement in the management of risk factors in clinical settings.Conclusions: Diabetes mellitus is growing in SSA. Related cardiovascular diseases are emerging as potential health problem. Heart failure as cardiovascular complication remains largely unexplored. Efforts are needed through research to improve our knowledge of heart failure at large in Africa. Multilevel preventive measures, building on evidences from other parts of the world must go along side.Keywords: diabetes mellitus, cardiovascular diseases, heart failure, sub-Saharan Africa
Authors:
Alain Lekoubou , author
Paschal Awah , author
Leopold Fezeu , author
Eugene Sobngwi , author
Andre Pascal Kengne , author
Date:
2010-01-01
Journal:
Content:
Chronic diseases are becoming increasingly important in sub-Saharan Africa (SSA). The current density and distribution of health workforce suggest that SSA cannot respond to the growing demand for chronic disease care, together with the frequent infectious diseases. Innovative approaches are therefore needed to rapidly expand the health workforce. In this article, we discuss the evidences in support of nurse-led strategies for chronic disease management in SSA, with a focus on hypertension and diabetes mellitus.
Authors:
Kengne AP , author
Masconi K , author
Mbanya VN , author
Lekoubou A , author
Echouffo-Tcheugui JB , author
Matsha TE , author
Date:
2013-12-01
Journal:
Critical reviews in clinical laboratory sciences
Content:
Authors:
Yone EW , author
Kengne AP , author
Date:
2012-12-01
Journal:
HIV/AIDS (Auckland, N.Z.)
Content:
Authors:
Ruffieux N , author
Njamnshi AK , author
Mayer E , author
Sztajzel R , author
Eta SC , author
Doh RF , author
Kengne AM , author
Ngamaleu RN , author
Chanal J , author
Verdon V , author
Hauert CA , author
Date:
2009-04-01
Journal:
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
Content:
Authors:
George C , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Date:
2018-11-01
Journal:
BMJ open
Content:
Authors:
Camara A , author
Baldé NM , author
Sobngwi-Tambekou J , author
Kengne AP , author
Diallo MM , author
Tchatchoua AP , author
Kaké A , author
Sylvie N , author
Balkau B , author
Bonnet F , author
Sobngwi E , author
Date:
2014-09-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
Mazidi M , author
Kengne AP , author
Katsiki N , author
Mikhailidis DP , author
Banach M , author
Date:
2017-10-01
Journal:
Journal of diabetes and its complications
Content:
Authors:
Lekoubou Looti AZ , author
Kengne AP , author
Djientcheu Vde P , author
Kuate CT , author
Njamnshi AK , author
Date:
2010-07-01
Journal:
Journal of neurology, neurosurgery, and psychiatry
Content:
Authors:
Peer N , author
George C , author
Kengne AP , author
Date:
2019-12-01
Journal:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Content:
Authors:
Clement N. Kufe , author
Lisa K. Micklesfield , author
Maphoko Masemola , author
Tinashe Chikowore , author
Andre Pascal Kengne , author
Fredrik Karpe , author
Shane A. Norris , author
Nigel J. Crowther , author
Tommy Olsson , author
Julia H. Goedecke , author
Date:
2021-10-26
Journal:
Content:
Authors:
Theodosia Adom , author
Anniza De Villiers , author
Thandi Puoane , author
André Pascal Kengne , author
Date:
2021-11-11
Journal:
Nutrients
Content:
Authors:
Duan D , author
Kengne AP , author
Echouffo-Tcheugui JB , author
Date:
2021-07-01
Journal:
Endocrinology and metabolism clinics of North America
Content:
Authors:
Mutemwa M , author
Peer N , author
de Villiers A , author
Mukasa B , author
Matsha TE , author
Mills EJ , author
Kengne AP , author
Date:
2018-08-01
Journal:
Medicine
Content:
Authors:
Choukem SP , author
Dzudie A , author
Dehayem M , author
Halle MP , author
Doualla MS , author
Luma H , author
Kengne AP , author
Date:
2012-04-01
Journal:
The Pan African medical journal
Content:
Authors:
Nguyen KA , author
Peer N , author
Mills EJ , author
Kengne AP , author
Date:
2016-03-01
Journal:
PloS one
Content:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
L. J. Cheskin , author
Maciej Banach , author
Date:
2018-01-01
Journal:
Content:
Abstract Background To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults. Methods Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights. Results Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-β-carotene, cis- β-carotene, β-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001). Conclusions Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.
Authors:
Mazidi M , author
Shivappa N , author
Wirth MD , author
Hebert JR , author
Vatanparast H , author
Kengne AP , author
Date:
2017-10-01
Journal:
European journal of clinical nutrition
Content:
Authors:
Pefura-Yone EW , author
Mbele-Onana CL , author
Balkissou AD , author
Kenmegne-Noumsi EC , author
Boulleys-Nana JR , author
Kolontchang-Yomi BL , author
Theubo-Kamgang BJ , author
Ndjeutcheu-Moualeu PI , author
for Groupe Enquête en Santé Respiratoire au Cameroun (GESRC) , author
Date:
2015-07-01
Journal:
The Journal of asthma : official journal of the Association for the Care of Asthma
Content:
Authors:
Kassebaum NJ , author
Bertozzi-Villa A , author
Coggeshall MS , author
Shackelford KA , author
Steiner C , author
Heuton KR , author
Gonzalez-Medina D , author
Barber R , author
Huynh C , author
Dicker D , author
Templin T , author
Lozano R , author
Date:
2014-05-01
Journal:
Lancet (London, England)
Content:
Authors:
Ibrahim Chikowe , author
Victor Mwapasa , author
Andre Pascal Kengne , author
Date:
2018-01-01
Journal:
Content:
Abstract Objective There is limited data on the quality of primary care management for diabetes mellitus across Africa. The study was aimed at assessing the availability of basic supplies for the rapid diagnosis, treatment and management of diabetes in Malawian rural health facilities. This cross-sectional study was conducted in 55 public and private health centers from 19 districts using a structured questionnaire and checklist to interview the pharmacy personnel or officer in-charge of the health centers. We focused on availability of information, diagnosis and treatment materials for diabetes. Results Of the 55 health facilities surveyed, 21, 23 and 11 were located in the central, southern and northern regions of Malawi, respectively. Overall, 38% (21/55) of the health centres had glucometers, while 24% (13/55) had urine glucose dipsticks. Only 4% (2/55) of the health centres had recommended first-line medicines for treatment of type 1 and type 2 diabetes. No health centre had diabetes patient records and information, education and communication materials. Most rural health centers in Malawi lack basic health commodities for the screening, diagnosis and treatment of diabetes and this impedes on their effective management of growing diabetes burden. Therefore, health care systems need to adequately equip primary care facilities.
Authors:
Kaze FF , author
Halle MP , author
Mopa HT , author
Ashuntantang G , author
Fouda H , author
Ngogang J , author
Kengne AP , author
Date:
2015-07-01
Journal:
BMC nephrology
Content:
Authors:
Pefura-Yone EW , author
Kengne AP , author
Balkissou AD , author
Magne-Fotso CG , author
Ngo-Yonga M , author
Boulleys-Nana JR , author
Efe-de-Melingui NR , author
Ndjeutcheu-Moualeu PI , author
Mbele-Onana CL , author
Respiratory Health Survey Group in Cameroon (RHSGC) , author
Date:
2016-02-01
Journal:
BMC research notes
Content:
Authors:
Noumegni SR , author
Ama VJM , author
Assah FK , author
Bigna JJ , author
Nansseu JR , author
Kameni JAM , author
Katte JC , author
Dehayem MY , author
Kengne AP , author
Sobngwi E , author
Date:
2017-07-01
Journal:
Tropical diseases, travel medicine and vaccines
Content:
Authors:
Gouda HN , author
Charlson F , author
Sorsdahl K , author
Ahmadzada S , author
Ferrari AJ , author
Erskine H , author
Leung J , author
Santamauro D , author
Lund C , author
Aminde LN , author
Mayosi BM , author
Kengne AP , author
Harris M , author
Whiteford H , author
Date:
2019-10-01
Journal:
The Lancet. Global health
Content:
Authors:
Kengne AP , author
Ntsekhe M , author
Date:
2018-05-01
Journal:
Circulation
Content:
Authors:
Masconi KL , author
Echouffo-Tcheugui JB , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Date:
2015-02-01
Journal:
Expert review of endocrinology & metabolism
Content:
Authors:
Goedecke JH , author
Mtintsilana A , author
Dlamini SN , author
Kengne AP , author
Date:
2016-12-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
Kengne AP , author
Limen SN , author
Sobngwi E , author
Djouogo CF , author
Nouedoui C , author
Date:
2012-05-01
Journal:
Diabetology & metabolic syndrome
Content:
Authors:
Kaze FF , author
Maimouna M , author
Beybey AF , author
Pefura-Yone EW , author
Balkissou AD , author
Halle MP , author
Kowo MP , author
Ashuntantang G , author
Kengne AP , author
Date:
2021-03-01
Journal:
Clinical and experimental nephrology
Content:
Authors:
Peer N , author
Kengne AP , author
Motala AA , author
Mbanya JC , author
Date:
2013-12-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
Kengne AP , author
Sobngwi E , author
Fezeu LL , author
Awah PK , author
Dongmo S , author
Mbanya JC , author
Date:
2008-08-01
Journal:
The Journal of asthma : official journal of the Association for the Care of Asthma
Content:
Authors:
Jun Hata , author
Hisatomi Arima , author
Sophia Zoungas , author
Greg Fulcher , author
Carol Pollock , author
Mark Adams , author
John Watson , author
Rohina Joshi , author
Andre Pascal Kengne , author
Toshiharu Ninomiya , author
Craig Anderson , author
Mark Woodward , author
Anushka Patel , author
Giuseppe Mancia , author
Neil Poulter , author
Stephen MacMahon , author
John Chalmers , author
Bruce Neal , author
Date:
Journal:
Content:
Endpoint adjudication committees (EPAC) are widely used in clinical trials. The aim of the present analysis is to assess the effects of the endpoint adjudication process on the main findings of the ADVANCE trial (Trial registration: ClinicalTrials.gov NCT00145925).The ADVANCE trial was a multicentre, 2 × 2 factorial randomised controlled trial of blood pressure lowering and intensive blood glucose control in 11140 patients with type 2 diabetes. Primary outcomes were major macrovascular (nonfatal myocardial infarction, nonfatal stroke and cardiovascular death) and microvascular (new or worsening nephropathy and retinopathy) events. Suspected primary outcomes were initially reported by the investigators at the 215 sites with subsequent adjudication by the EPAC. The EPAC also adjudicated upon potential events identified directly by ongoing screening of all reported events. Over a median follow-up of 5 years, the site investigators reported one or more primary outcomes among 2443 participants. After adjudication these events were confirmed for 2077 (85%) with 48 further events added through the EPAC-led database screening process. The estimated relative risk reductions (95% confidence intervals) in the primary outcome for the blood pressure lowering comparison were 8% (-1 to 15%) based on the investigator-reported events and 9% (0 to 17%) based on the EPAC-based events (P for homogeneity = 0.70). The corresponding findings for the glucose comparison were 8% (1 to 15%) and 10% (2% to 18%) (P for homogeneity = 0.60). The effect estimates were also highly comparable when studied separately for macrovascular events and microvascular events for both comparisons (all P for homogeneity>0.6).The endpoint adjudication process had no discernible impact on the main findings in ADVANCE. These data highlight the need for careful consideration of the likely impact of an EPAC on the findings and conclusions of clinical trials prior to their establishment.
Authors:
Dzudie A , author
Njume E , author
Mfekeu LK , author
Djomou A , author
Ba H , author
Ndom MS , author
Nkoke C , author
Ndongo S , author
Boombhi J , author
Kamdem F , author
Mouandjo JPD , author
Mouliom SA , author
Kouam CK , author
Meli H , author
Monkam Y , author
Cameroon Cardiac Society and MMM Cameroon investigator group , author
Date:
2021-05-01
Journal:
European heart journal supplements : journal of the European Society of Cardiology
Content:
Authors:
Date:
2005-12-01
Journal:
Circulation
Content:
BACKGROUND: Cardiovascular disease, the major cause of mortality and morbidity in modern societies, is set to overtake infectious diseases in the developing world as the most common cause of death. The increasing prevalence of major and emerging cardiovascular risk factors accounts for the growing burden of cardiovascular disease in the world. Diabetes in all its forms is one of the main cardiovascular risk factors. Two of 3 diabetic patients will die as a result of cardiovascular complications, and approximately 30% of patients treated in cardiovascular intensive care units have diabetes. METHODS AND RESULTS: This review on the cardiovascular complications of diabetes in sub-Saharan Africa is a bibliographical MEDLINE search of published data over the past 2 decades. Diabetes-related cardiovascular disease complications are considered to be rare in Africa but are on the rise and are regularly associated with classic cardiovascular risk factors. Coronary heart disease may affect 5% to 8% of type 2 diabetic patients and cardiomyopathy, up to 50% of all patients. Close to 15% of patients with stroke have diabetes, and up to 5% of diabetic patients present with cerebrovascular accidents at diagnosis. Peripheral vascular disease prevalence varies across sites from 4% to 28%. CONCLUSIONS: It is obvious that diabetes mellitus and related cardiovascular complications are gaining more importance in sub-Saharan Africa. The relative contribution of putative risk factors is not well defined, and further research is therefore needed.
Authors:
Halle MP , author
Zebaze PN , author
Mbofung CM , author
Kaze F , author
Mbiatat H , author
Ashuntantang G , author
Kengne AP , author
Date:
2014-01-01
Journal:
Journal of nephrology
Content:
Authors:
Echouffo-Tcheugui JB , author
Kengne AP , author
Date:
2013-09-01
Journal:
Diabetes & metabolism
Content:
Authors:
Mohsen Mazidi , author
Hong-kai Gao , author
Andre Pascal Kengne , author
Date:
2017-01-01
Journal:
Journal of Nutrition and Metabolism
Content:
Authors:
Tandi E. Matsha , author
Saaiga Ismail , author
Aladdin Speelman , author
Gloudina M. Hon , author
Saarah Davids , author
Rajiv T. Erasmus , author
Andre P. Kengne , author
Date:
2019-08-01
Journal:
Clinical Nutrition ESPEN
Content:
Authors:
Noubiap JJ , author
Nansseu JR , author
Bigna JJ , author
Jingi AM , author
Kengne AP , author
Date:
2015-03-01
Journal:
BMJ open
Content:
Authors:
Noubiap JJ , author
Agbaedeng TA , author
Ndoadoumgue AL , author
Nyaga UF , author
Kengne AP , author
Date:
2021-05-01
Journal:
Journal of cardiovascular electrophysiology
Content:
Authors:
Eric Walter Pefura-Yone , author
Adamou Dodo Balkissou , author
Virginie Poka-Mayap , author
Hadja Koté Fatime-Abaicho , author
Patrick Thierry Enono-Edende , author
André Pascal Kengne , author
Date:
2017-01-01
Journal:
Content:
Abstract Background Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas. Methods We used data for patients aged ≥15 years, diagnosed and treated for tuberculosis at the Yaounde Jamot Hospital between January 2012 and December 2013. Baseline characteristics associated with mortality were investigated using logistic regressions. A simple prognosis score (CABI) was constructed with regression coefficients for predictors in the final model. Internal validation used bootstrap resampling procedures. Models discrimination was assessed using c-statistics and calibration assessed via calibration plots and the Hosmer and Lemeshwow (H-L) statistics. The optimal score was based on the Youden’s index. Results A total of 2250 patients (men 57.2%) with a mean age of 35.8 years were included; among whom 213 deaths (cumulative incidence 9.5%) were recorded. Clinical form of tuberculosis (C), age (A, years), adjusted body mass index (B, BMI, kg/m2) and status for HIV (Human immunodefiency virus) infection (I) were significant predictors in the final model (p < 0.0001) which was of the form Death risk = 1/(1 + e − (−1.3120 + 0.0474 ∗ age − 0.1866 ∗ BMI + 1.1637 (if smear negative TB) + 0.5418(if extra − pulmonary TB) + 1.3820(if HIV+))). The c-statistic was 0.812 in the derivation sample and 0.808 after correction for optimism. The calibration was good [H-Lχ2 = 6.44 (p = 0.60)]. The optimal absolute risk threshold was 4.8%, corresponding to a sensitivity of 81% and specificity of 67%. Conclusions The preliminary promising findings from this study require confirmation through independent external validation studies. If confirmed, the model derived could facilitate the stratification of TB patients for mortality risk and implementation of additional monitoring and management measures in vulnerable patients.
Authors:
Khazdouz M , author
Mazidi M , author
Ehsaei MR , author
Ferns G , author
Kengne AP , author
Norouzy AR , author
Date:
2017-05-01
Journal:
Journal of dietary supplements
Content:
Authors:
Arthemon Nguweneza , author
Chandré Oosterwyk , author
Kambe Banda , author
Victoria Nembaware , author
Gaston Mazandu , author
Andre P Kengne , author
Ambroise Wonkam , author
Date:
2022-04-03
Journal:
Expert Review of Hematology
Content:
Authors:
Nguyen KA , author
Peer N , author
de Villiers A , author
Mukasa B , author
Matsha TE , author
Mills EJ , author
Kengne AP , author
Date:
2017-09-01
Journal:
PloS one
Content:
Authors:
Theodosia Adom , author
André Pascal Kengne , author
Anniza De Villiers , author
Rose Boatin , author
Thandi Puoane , author
Date:
2019-12-19
Journal:
International Journal of Environmental Research and Public Health
Content:
Authors:
Kengne AP , author
Czernichow S , author
Stamatakis E , author
Hamer M , author
Batty GD , author
Date:
2012-07-01
Journal:
Diabetes & vascular disease research
Content:
Authors:
Zemlin AE , author
Matsha TE , author
Kengne AP , author
Hon G , author
Erasmus RT , author
Date:
2016-10-01
Journal:
Journal of medical biochemistry
Content:
Authors:
George C , author
Goedecke JH , author
Crowther NJ , author
Jaff NG , author
Kengne AP , author
Norris SA , author
Micklesfield LK , author
Date:
2016-05-01
Journal:
PloS one
Content:
Authors:
Businge CB , author
Madini N , author
Longo-Mbenza B , author
Kengne AP , author
Date:
2019-05-01
Journal:
BMJ open
Content:
Authors:
Kanmogne GD , author
Fonsah JY , author
Umlauf A , author
Moul J , author
Doh RF , author
Kengne AM , author
Tang B , author
Tagny CT , author
Nchindap E , author
Kenmogne L , author
Franklin D , author
Njamnshi DM , author
Kuate CT , author
Mbanya D , author
Heaton RK , author
Date:
2020-08-01
Journal:
Scientific reports
Content:
Authors:
Gertrude Nsorma Nyaaba , author
Karien Stronks , author
Ama de-Graft Aikins , author
Andre Pascal Kengne , author
Charles Agyemang , author
Date:
2017-01-01
Journal:
Content:
Abstract Background Half of the estimated annual 28 million non-communicable diseases (NCDs) deaths in low- and middle-income countries (LMICs) are attributed to weak health systems. Current health policy responses to NCDs are fragmented and vertical particularly in the African region. The World Health Organization (WHO) led NCDs Global action plan 2013–2020 has been recommended for reducing the NCD burden but it is unclear whether Africa is on track in its implementation. This paper synthesizes Africa’s progress towards WHO policy recommendations for reducing the NCD burden. Methods Data from the WHO 2011, 2014 and 2015 NCD reports were used for this analysis. We synthesized results by targets descriptions in the three reports and included indicators for which we could trace progress in at least two of the three reports. Results More than half of the African countries did not achieve the set targets for 2015 and slow progress had been made towards the 2016 targets as of December 2013. Some gains were made in implementing national public awareness programmes on diet and/or physical activity, however limited progress was made on guidelines for management of NCD and drug therapy and counselling. While all regions in Africa show waning trends in fully achieving the NCD indicators in general, the Southern African region appears to have made the least progress while the Northern African region appears to be the most progressive. Conclusion Our findings suggest that Africa is off track in achieving the NCDs indicators by the set deadlines. To make sustained public health gains, more effort and commitment is urgently needed from governments, partners and societies to implement these recommendations in a broader strategy. While donors need to suit NCD advocacy with funding, African institutions such as The African Union (AU) and other sub-regional bodies such as West African Health Organization (WAHO) and various country offices could potentially play stronger roles in advocating for more NCD policy efforts in Africa.
Authors:
Kajawo S , author
Moloi MW , author
Noubiap JJ , author
Ekrikpo U , author
Kengne AP , author
Okpechi IG , author
Date:
2018-04-01
Journal:
BMJ open
Content:
Authors:
Kanmogne GD , author
Fonsah JY , author
Tang B , author
Doh RF , author
Kengne AM , author
Umlauf A , author
Tagny CT , author
Nchindap E , author
Kenmogne L , author
Franklin D , author
Njamnshi DM , author
Mbanya D , author
Njamnshi AK , author
Heaton RK , author
Date:
2018-12-01
Journal:
Scientific reports
Content:
Authors:
Kajawo S , author
Ekrikpo U , author
Moloi MW , author
Noubiap JJ , author
Osman MA , author
Okpechi-Samuel US , author
Kengne AP , author
Bello AK , author
Okpechi IG , author
Date:
2020-11-01
Journal:
Kidney international reports
Content:
Authors:
Andre Pascal Kengne , author
Anastase Dzudie , author
Eugene Sobngwi , author
Correspondence Andre , author
Pascal Kengne , author
Date:
Journal:
Content:
Purpose: Heart failure is the ultimate complication of cardiac involvements in diabetes. The purpose of this review was to summarize current literature on heart failure among people with diabetes mellitus in sub-Saharan Africa (SSA). Method: Bibliographic search of published data on heart failure and diabetes in sub-Saharan Africa over the past 26 years. Results: Heart failure remains largely unexplored in general population and among people with diabetes in Africa. Heart failure accounts for over 30 % of hospital admission in specialized cardiovascular units and 3%–7 % in general internal medicine. Over 11 % of adults with heart failure have diabetes. Risk factors for heart failure among those with diabetes include classical cardiovascular risk factors, without evidence of diabetes distinctiveness for other predictors common in Africa. Prevention, management, and outcomes of heart failure are less well known; recent data suggest improvement in the management of risk factors in clinical settings. Conclusions: Diabetes mellitus is growing in SSA. Related cardiovascular diseases are emerging as potential health problem. Heart failure as cardiovascular complication remains largely unexplored. Efforts are needed through research to improve our knowledge of heart failure at large in Africa. Multilevel preventive measures, building on evidences from other parts of the world must go along side.
Authors:
Oluwatoyin I. Ameh , author
Udeme E. Ekrikpo , author
Andre-Pascal Kengne , author
Date:
2020-03-01
Journal:
Kidney International Reports
Content:
Authors:
Tesema AG , author
Ajisegiri WS , author
Abimbola S , author
Balane C , author
Kengne AP , author
Shiferaw F , author
Dangou JM , author
Narasimhan P , author
Joshi R , author
Peiris D , author
Date:
2020-10-01
Journal:
PloS one
Content:
Authors:
Caleyachetty R , author
Echouffo-Tcheugui JB , author
Tait CA , author
Schilsky S , author
Forrester T , author
Kengne AP , author
Date:
2015-05-01
Journal:
The lancet. Diabetes & endocrinology
Content:
Authors:
Dzudie A , author
Njume E , author
Abanda M , author
Aminde L , author
Hamadou B , author
Dzekem B , author
Azabji M , author
Doualla MS , author
Ngowe M , author
Kengne AP , author
Date:
2020-03-01
Journal:
PloS one
Content:
Authors:
Peer N , author
Kengne AP , author
Date:
2016-12-01
Journal:
Global heart
Content:
Authors:
Kengne AP , author
Djouogo CF , author
Dehayem MY , author
Fezeu L , author
Sobngwi E , author
Lekoubou A , author
Mbanya JC , author
Date:
2009-12-01
Journal:
The international journal of lower extremity wounds
Content:
Authors:
Haagsma JA , author
James SL , author
Castle CD , author
Dingels ZV , author
Fox JT , author
Hamilton EB , author
Liu Z , author
Lucchesi LR , author
Roberts NLS , author
Sylte DO , author
Adebayo OM , author
Ahmadi A , author
Ahmed MB , author
Vos T , author
Date:
2020-01-01
Journal:
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention
Content:
Authors:
Kengne AP , author
Fezeu LL , author
Awah PK , author
Sobngwi E , author
Dongmo S , author
Mbanya JC , author
Date:
2008-09-01
Journal:
Epilepsia
Content:
Authors:
Mazidi M , author
Gao HK , author
Kengne AP , author
Date:
2018-07-01
Journal:
Scientific reports
Content:
Authors:
Motamed S , author
Mazidi M , author
Safarian M , author
Ghayour-Mobarhan M , author
Moohebati M , author
Ebrahimi M , author
Azarpazhooh MR , author
Heidari-Bakavoli A , author
Esmaily H , author
Baghestani A , author
Ferns GA , author
Date:
2019-05-01
Journal:
ARYA atherosclerosis
Content:
Authors:
Nembaware V , author
Mazandu GK , author
Hotchkiss J , author
Safari Serufuri JM , author
Kent J , author
Kengne AP , author
Anie K , author
Munung NS , author
Bukini D , author
Bitoungui VJN , author
Munube D , author
Chirwa U , author
Wonkam A , author
Date:
2020-10-01
Journal:
Omics : a journal of integrative biology
Content:
Authors:
Masconi K , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Date:
2015-05-01
Journal:
Diabetology & metabolic syndrome
Content:
Authors:
Kengne AP , author
Choukem SP , author
Dehayem YM , author
Simo NL , author
Fezeu LL , author
Mbanya JC , author
Date:
2006-09-01
Journal:
Journal of wound care
Content:
Authors:
Pasmore Malambo , author
Andre P. Kengne , author
Estelle V. Lambert , author
Anniza De Villers , author
Thandi Puoane , author
Date:
2016-06-15
Journal:
Advances in Epidemiology
Content:
Authors:
Businge CB , author
Longo-Mbenza B , author
Kengne AP , author
Date:
2020-08-01
Journal:
Public health nutrition
Content:
Authors:
Francois FolefackKaze , author
Andre-Pascal Kengne , author
Eric Walter PefuraYone , author
Nelly Sandra NdamFemben , author
Gloria Ashuntantang , author
Date:
2013-01-01
Journal:
Content:
As per guidelines and recommendations, screening for renal diseases should be performed at the time of diagnosis of human immuno-deficiency virus (HIV) infection; however, this remains largely unimplemented in many settings across Sub-Saharan Africa. We evaluated the renal function, urinalysis abnormalities and their correlates in HIV-infected individuals who were naïve to highly active antiretroviral therapy (HAART). This was a cross-sectional study of 2 months′ duration involving 104 HIV-infected outpatients naive to HAART (71 women, 68%) attending the HIV clinic of the Yaoundé General Hospital in Cameroon. Renal and urinalysis parameters were measured and the Student t-test and Fischer exact test were used to compare the groups of participants. The mean age and CD4 count were, respectively, 35 ± 10.7 years and 305 ± 202/mL. Fifty-six (54%) patients presented with stages 3 and 4 of HIV infection. Forty-three (41%) patients had urinalysis abnormalities, including proteinuria (36%), leukocyturia (13%) and hematuria (12%). Proteinuria was associated with increased age, advanced stage of HIV infection, decreased CD4 count, hematuria and renal failure (P <0.04). Hematuria and leukocyturia were associated with decreased CD4 count and advanced stage of HIV infection, respectively (P = 0.04). The mean estimated glomerular filtration (eGFR) rate was100.2 ± 32.7 mL/min; three (3%) patients had renal failure (eGFR <60 mL/min) and 45 (43%) patients had reduced kidney function 60 ≤eGFR ≤90 mL/min. There was a high prevalence of decreased kidney function and proteinuria among Cameroonian HIV-infected patients naïve to HAART. Indicators of the severity of HIV infection, including advanced stage and low CD4 count, were associated with urinalysis abnormalities.
Authors:
Simo N , author
Kuate-Tegueu C , author
Ngankou-Tchankeu S , author
Doumbe J , author
Maiga Y , author
Cesari M , author
Dartigues JF , author
Kengne AP , author
Tabue-Teguo M , author
Date:
2020-10-01
Journal:
PloS one
Content:
Authors:
Eric Walter Pefura-Yone , author
André Pascal Kengne , author
Adamou Dodo Balkissou , author
Julie Raïcha Boulleys-Nana , author
Nelly Rachel Efe-de-Melingui , author
Patricia Ingrid Ndjeutcheu-Moualeu , author
Charles Lebon Mbele-Onana , author
Elvira Christelle Kenmegne-Noumsi , author
Barbara Linda Kolontchang-Yomi , author
Boris Judicaël Theubo-Kamgang , author
Emilienne Régine Ebouki , author
Chrystelle Karen Djuikam-Kamga , author
Christiane Gaelle Magne-Fotso , author
Francine Amougou , author
Liliane Mboumtou , author
Martine Ngo-Yonga , author
Elsie Linda Petchou-Talla , author
Emmanuel Afane-Ze , author
Christopher Kuaban , author
Date:
Journal:
Content:
Population-based estimates of asthma and allergic rhinitis in sub-Saharan African adults are lacking. We assessed the prevalence and determinants of asthma and allergic rhinitis in urban adult Cameroonians.A community-based survey was conducted from December 2013 to April 2014 among adults aged 19 years and above (N = 2,304, 57.3% women), selected through multilevel stratified random sampling across all districts of Yaounde (Capital city). Internationally validated questionnaires were used to investigate the presence of allergic diseases. Logistic regressions were employed to investigate the determinants of allergic conditions.Prevalence rates were 2.7% (95% CI: 2.1-3.4) for asthma-ever, 6.9% (5.9-7.9) for lifetime wheezing, 2.9% (92.2-3.6) for current wheezing and 11.4% (10.1-12.7) for self-reported lifetime allergic rhinitis; while 240 (10.4%) participants reported current symptoms of allergic rhinitis, and 125 (5.4%) had allergic rhino-conjunctivitis. The prevalence of current asthma medication use and self-reported asthma attack was 0.8 (0.4-1.2) and 1 (0.6-1.4) respectively. Multivariable adjusted determinants of current wheezing were signs of atopic eczema [2.91 (1.09-7.74)] and signs of allergic rhinitis [3.24 (1.83-5.71)]. Age group 31-40 years [0.27(0.09-0.78), p = 0.016] was an independent protective factor for wheezing. Determinants of current rhinitis symptoms were active smoking [2.20 (1.37-3.54), p<0.001], signs of atopic eczema [2.84 (1.48-5.46)] and current wheezing [3.02 (1.70-5.39)].Prevalence rates for asthma and allergic rhinitis among adults in this population were at the lower tails of those reported in other regions of the world. Beside the classical interrelation between allergic diseases found in this study, active smoking was an independent determinant of allergic rhinitis symptoms. Nationwide surveys are needed to investigate regional variations.
Authors:
Aminde LN , author
Dzudie A , author
Takah NF , author
Ngu KB , author
Sliwa K , author
Kengne AP , author
Date:
2015-04-01
Journal:
Cardiovascular diagnosis and therapy
Content:
Authors:
Lopes T , author
Zemlin AE , author
Erasmus RT , author
Faber M , author
Kengne AP , author
Date:
2020-06-01
Journal:
BMJ open
Content:
Authors:
Werfalli M , author
Engel ME , author
Musekiwa A , author
Kengne AP , author
Levitt NS , author
Date:
2015-11-01
Journal:
The lancet. Diabetes & endocrinology
Content:
Authors:
Ndadza A , author
Cindi Z , author
Makambwa E , author
Chimusa E , author
Wonkam A , author
Kengne AP , author
Ntsekhe M , author
Dandara C , author
Date:
2018-12-01
Journal:
Omics : a journal of integrative biology
Content:
Authors:
Masconi KL , author
Matsha TE , author
Echouffo-Tcheugui JB , author
Erasmus RT , author
Kengne AP , author
Date:
2015-03-01
Journal:
The EPMA journal
Content:
Authors:
Feteh VF , author
Choukem SP , author
Kengne AP , author
Nebongo DN , author
Ngowe-Ngowe M , author
Date:
2016-03-01
Journal:
BMC nephrology
Content:
Authors:
Davids SFG , author
Matsha TE , author
Peer N , author
Erasmus RT , author
Kengne AP , author
Date:
2019-06-01
Journal:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Content:
Authors:
Rohina Joshi , author
Mohammed Alim , author
Andre Pascal Kengne , author
Stephen Jan , author
Pallab K Maulik , author
David Peiris , author
Anushka A Patel , author
Date:
Journal:
Content:
One potential solution to limited healthcare access in low and middle income countries (LMIC) is task-shifting- the training of non-physician healthcare workers (NPHWs) to perform tasks traditionally undertaken by physicians. The aim of this paper is to conduct a systematic review of studies involving task-shifting for the management of non-communicable disease (NCD) in LMIC.A search strategy with the following terms "task-shifting", "non-physician healthcare workers", "community healthcare worker", "hypertension", "diabetes", "cardiovascular disease", "mental health", "depression", "chronic obstructive pulmonary disease", "respiratory disease", "cancer" was conducted using Medline via Pubmed and the Cochrane library. Two reviewers independently reviewed the databases and extracted the data.Our search generated 7176 articles of which 22 were included in the review. Seven studies were randomised controlled trials and 15 were observational studies. Tasks performed by NPHWs included screening for NCDs and providing primary health care. The majority of studies showed improved health outcomes when compared with usual healthcare, including reductions in blood pressure, increased uptake of medications and lower depression scores. Factors such as training of NPHWs, provision of algorithms and protocols for screening, treatment and drug titration were the main enablers of the task-shifting intervention. The main barriers identified were restrictions on prescribing medications and availability of medicines. Only two studies described cost-effective analyses, both of which demonstrated that task-shifting was cost-effective.Task-shifting from physicians to NPHWs, if accompanied by health system re-structuring is a potentially effective and affordable strategy for improving access to healthcare for NCDs. Since the majority of study designs reviewed were of inadequate quality, future research methods should include robust evaluations of such strategies.
Authors:
Mashiane JT , author
Monyeki KD , author
Kengne AP , author
Rosina NM , author
Monyeki MS , author
Date:
2018-09-01
Journal:
Cardiovascular journal of Africa
Content:
Authors:
GBD 2017 Mortality Collaborators , author
Date:
2018-11-01
Journal:
Lancet (London, England)
Content:
Authors:
Krishnamurthi RV , author
deVeber G , author
Feigin VL , author
Barker-Collo S , author
Fullerton H , author
Mackay MT , author
O'Callahan F , author
Lindsay MP , author
Kolk A , author
Lo W , author
Shah P , author
Linds A , author
Jones K , author
GBD 2013 Stroke Panel Experts Group , author
Date:
2015-10-01
Journal:
Neuroepidemiology
Content:
Authors:
Macharia M , author
Kengne AP , author
Blackhurst DM , author
Erasmus RT , author
Matsha TE , author
Date:
2014-11-01
Journal:
Mediators of Inflammation
Content:
Authors:
Mbanya VN , author
Echouffo-Tcheugui JB , author
Akhtar H , author
Mbanya JC , author
Kengne AP , author
Date:
2015-03-01
Journal:
Diabetology & metabolic syndrome
Content:
Authors:
Ameh OI , author
Okpechi IG , author
Dandara C , author
Kengne AP , author
Date:
2017-03-01
Journal:
Omics : a journal of integrative biology
Content:
Authors:
Park JJH , author
Grais RF , author
Taljaard M , author
Nakimuli-Mpungu E , author
Jehan F , author
Nachega JB , author
Ford N , author
Xavier D , author
Kengne AP , author
Ashorn P , author
Socias ME , author
Bhutta ZA , author
Mills EJ , author
Date:
2021-05-01
Journal:
The Lancet. Global health
Content:
Authors:
Caleyachetty R , author
Thomas GN , author
Kengne AP , author
Echouffo-Tcheugui JB , author
Schilsky S , author
Khodabocus J , author
Uauy R , author
Date:
2018-08-01
Journal:
The American journal of clinical nutrition
Content:
Authors:
Kengne AP , author
Mayosi BM , author
Date:
2013-05-01
Journal:
Cardiovascular journal of Africa
Content:
Authors:
Pefura-Yone EW , author
Kengne AP , author
Tagne-Kamdem PE , author
Afane-Ze E , author
Date:
2014-07-01
Journal:
BMJ open
Content:
Authors:
Ekrikpo UE , author
Akpan EE , author
Ekott JU , author
Bello AK , author
Okpechi IG , author
Kengne AP , author
Date:
2018-07-01
Journal:
BMJ open
Content:
Authors:
Echouffo-Tcheugui JB , author
Dzudie A , author
Epacka ME , author
Choukem SP , author
Doualla MS , author
Luma H , author
Kengne AP , author
Date:
2012-06-01
Journal:
Primary care diabetes
Content:
Authors:
Pule GD , author
Ngo Bitoungui VJ , author
Chetcha Chemegni B , author
Kengne AP , author
Antonarakis S , author
Wonkam A , author
Date:
2015-09-01
Journal:
Omics : a journal of integrative biology
Content:
Authors:
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators , author
Date:
2017-09-01
Journal:
Lancet (London, England)
Content:
Authors:
Noubiap JJ , author
Naidoo J , author
Kengne AP , author
Date:
2015-06-01
Journal:
World journal of diabetes
Content:
Authors:
Irina, Balieva , author
Anastase, Dzudie , author
Friedrich, Thienemann , author
Mahmoud, U Sani , author
Andre, Pascal Kengne , author
Karen, Sliwa , author
Adriaan, A Voors , author
Ana, O Mocumbi , author
Kamilu, Karaye , author
Okechukwu, S Ogah , author
Date:
2017-01-01
Journal:
Content:
Authors:
Ndadza A , author
Muyambo S , author
Mnta P , author
Wonkam A , author
Chimusa E , author
Kengne AP , author
Ntsekhe M , author
Dandara C , author
Date:
2021-08-01
Journal:
Journal of thrombosis and haemostasis : JTH
Content:
Authors:
Dzudie A , author
Hoover D , author
Kim H , author
Ajeh R , author
Adedimeji A , author
Shi Q , author
Yone WP , author
Nforniwe DN , author
Njie KT , author
Kengne AP , author
Ebasone VP , author
Barche B , author
Cecile ZBA , author
Nash D , author
Yotebieng M , author
Anastos K , author
Date:
2020-08-01
Journal:
Content:
Authors:
NCD Risk Factor Collaboration (NCD-RisC) , author
Date:
2021-03-01
Journal:
eLife
Content:
Authors:
Malambo P , author
Kengne AP , author
Lambert EV , author
De Villers A , author
Puoane T , author
Date:
2017-02-01
Journal:
BMC public health
Content:
Authors:
Dzudie A , author
Kengne AP , author
Thienemann F , author
Sliwa K , author
Date:
2014-07-01
Journal:
BMJ open
Content:
Authors:
Joshi R , author
Kengne AP , author
Hersch F , author
Weber MB , author
McGuire H , author
Patel A , author
Date:
2018-09-01
Journal:
Content:
Authors:
Boateng D , author
Agyemang C , author
Beune E , author
Meeks K , author
Smeeth L , author
Schulze MB , author
Addo J , author
de-Graft Aikins A , author
Galbete C , author
Bahendeka S , author
Danquah I , author
Agyei-Baffour P , author
Klipstein-Grobusch K , author
Date:
2018-01-01
Journal:
International journal of cardiology
Content:
Authors:
Georgia E. Ritchie , author
Andre Pascal Kengne , author
Bruce Neal , author
Date:
Journal:
Content:
OBJECTIVE — To assess the utility of a point-of-care (POC) capillary blood glucose measurement as compared with routine clinical parameters in predicting undiagnosed diabetes in a low-resource rural India setting. RESEARCH DESIGN AND METHODS — Nine hundred and ninety-four participants aged �30 years and stratified by age and sex were randomly selected from 20 villages in India. A clinical questionnaire, sampling for laboratory venous fasting plasma glucose (FPG), and POC capillary blood glucose assay were performed simultaneously. Diabetes diagnosis was based on the World Health Organization (WHO) definition using FPG. The capacity of the POC glucose to predict the presence of diabetes was assessed and compared with the questionnaire using area under the receiver operating characteristic curves (AUCs). RESULTS — The AUC for POC glucose alone in predicting diabetes was 0.869 (95 % CI 0.810–0.929). This was significantly better (P � 0.001 for AUC comparison) than the models based upon clinical variables alone (AUC for the best clinical model including age, BMI, hypertension, waist circumference: 0.694 [95 % CI 0.621–0.766]). POC glucose appropriately reclassified the risk of up to one-third of participants ranked according to the clinical models. Adding the clinical variables to the POC glucose assay did not significantly improve the discriminatory capability beyond that achieved with the POC glucose measurement alone (all P � 0.37). CONCLUSIONS — POC glucose testing appears to be a simple and reliable tool for identifying undiagnosed diabetes in a high-risk, resource-poor rural population. However, studies evaluating the cost effectiveness of introducing POC glucose testing are needed prior to widespread implementation. The prevalence of type 2 diabetes is rapidly increasing around the world (1). Developing countries are facing the largest increases both in absolute and relative terms (1). It is predicted that this will have devastating consequences on the economies and health systems of these countries. Successful prevention and
Authors:
Cindy George , author
Tandi E Matsha , author
Florence E Davidson , author
Julia H Goedecke , author
Rajiv T Erasmus , author
Andre Pascal Kengne , author
Date:
2020-05-01
Journal:
International Journal of Nephrology and Renovascular Disease
Content:
Authors:
Mazidi M , author
Kengne AP , author
Banach M , author
Lipid and Blood Pressure Meta-analysis Collaboration Group , author
Date:
2017-08-01
Journal:
Pharmacological research
Content:
Authors:
van der Leeuw J , author
Visseren FL , author
Woodward M , author
Zoungas S , author
Kengne AP , author
van der Graaf Y , author
Glasziou P , author
Hamet P , author
MacMahon S , author
Poulter N , author
Grobbee DE , author
Chalmers J , author
Date:
2014-10-01
Journal:
Hypertension (Dallas, Tex. : 1979)
Content:
Authors:
Zoungas S , author
Chalmers J , author
Kengne AP , author
Pillai A , author
Billot L , author
de Galan B , author
Marre M , author
Neal B , author
Harrap S , author
Poulter N , author
Patel A , author
Date:
2010-06-01
Journal:
Diabetes research and clinical practice
Content:
Authors:
Aminde LN , author
Dzudie A , author
Kengne AP , author
Ndjebet J , author
Mapoh S , author
Kuelang X , author
Kamdem F , author
Mbatchou Ngahane BH , author
Doualla MS , author
Ngu KB , author
Sliwa K , author
Thienemann F , author
Date:
2017-09-01
Journal:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Content:
Authors:
Peer N , author
Abrahams N , author
Kengne AP , author
Date:
2020-09-01
Journal:
Global heart
Content:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
Hassan Vatanparast , author
Date:
2017-01-01
Journal:
Content:
Background and Purpose. Leukocyte telomere length (LTL) is a biomarker of biologic age. Whether food security status modulates LTL is still unknown. We investigated the association between food security and LTL in participants of the 1999–2002 US National Health and Nutrition Examination Survey (NHANES). Methods. Analysis of covariance (ANCOVA) was used to evaluate the association between food security categories and LTL controlling for sex, race, and education and accounting for the survey design and sample weights. Results. We included 10,888 participants with 5228 (48.0%) being men. They were aged on average 44.1 years. In all, 2362 (21.7%) had less than high school, 2787 (25.6%) had achieved high school, while 5705 (52.5%) had done more than high school. In sex-, race-, and education-adjusted ANCOVA, average LTL (T/S ratio) for participants with high food security versus those with marginal, low, or very low food security was 1.32 versus 1.20 for the age group 25–35 years and 1.26 versus 1.11 for the 35–45 years, (p<0.001). Conclusion. The association between food insecurity and LTL shortening in young adults suggest that some of the future effects of food insecurity on chronic disease risk in this population could be mediated by telomere shortening.
Authors:
Mohsen Mazidi , author
Hong-kai Gao , author
Nitin Shivappa , author
Michael D. Wirth , author
James R Hebert , author
Andre Pascal Kengne , author
Date:
2017-01-01
Journal:
Content:
Abstract Background It has been suggested that trans fatty acids (TFAs) play an important role in cardiovascular diseases. We investigated the association between plasma TFAs and the dietary inflammatory index (DII) ™ in US adults. Methods National Health and Nutrition Examination Survey (NHANES) participants with data on plasma TFAs measured from 1999 to 2010 were included. Energy-adjusted-DII ™ (E-DII ™) expressed per 1000 kcal was calculated from 24-h dietary recalls. All statistical analyses accounted for the survey design and sample weights. Results Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age of the population was 47.1 years overall, 47.8 years for men and 46.5 years for women (p = 0.09). After adjustment for C-reactive protein, body-mass-index, smoking, race, age, education, and marital status in linear regressions, trans 9-hexadecenoic acid [β coefficient 0.068 (95% CI: 0.032 to 0.188)], trans 11-octadecenoic acid [β coefficient 0.143 (95% CI: 0.155 to 0.310)], trans 9-octadecenoic acid [β coefficient 0.122 (95% CI: 0.120 to 0.277)], trans 9, and trans 12-octadienoic acid [β coefficient 0.103 (95% CI: 0.090 to 0.247)] were positively associated with the DII (all p < 0.001). Conclusion The association of plasma TFAs with a marker of dietary inflammation suggests an underlying mechanism in the initiation and progression of cardiovascular diseases.
Authors:
Davison GM , author
Nkambule BB , author
Mkandla Z , author
Hon GM , author
Kengne AP , author
Erasmus RT , author
Matsha TE , author
Date:
2017-01-01
Journal:
Scientific reports
Content:
Authors:
Emmanuel Peprah , author
Bronwyn Myers , author
Andre-Pascal Kengne , author
Nasheeta Peer , author
Omar El-Shahawy , author
Temitope Ojo , author
Barbara Mukasa , author
Oliver Ezechi , author
Juliet Iwelunmor , author
Nessa Ryan , author
Fatoumata Sakho , author
John Patena , author
Joyce Gyamfi , author
Date:
2022-01-19
Journal:
International Journal of Environmental Research and Public Health
Content:
Authors:
Kaze FF , author
Maimouna M , author
Beybey AF , author
Pefura-Yone EW , author
Balkissou AD , author
Halle MP , author
Kowo MP , author
Ashuntantang G , author
Kengne A , author
Date:
2019-08-01
Journal:
Content:
Authors:
W Tobe S , author
Global Alliance for Chronic Diseases Hypertension Research Teams With the World Hypertension League , author
Date:
2016-06-01
Journal:
Journal of clinical hypertension (Greenwich, Conn.)
Content:
Authors:
Nasheeta Peer , author
Joel Msafiri Francis , editor
Anniza de Villiers , author