EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-03-01
End Date 2024-02-29
Project Code TMA2017GSF-1962
Status Active

Title

EDCTP-GSK fellowship: Cardiometabolic Diseases Risk Evaluation and Reduction in African People Living with HIV Infection

Objectives

The Cardiometabolic Diseases Risk Evaluation and Reduction in African People Living with HIV Infection (CaDERAL) aims to enhance the understanding of common CMDs, and improve their co-detection and co-management in African people living with HIV infection, through a program of research and capacity development based on a network of institutions led by the South African Medical Research Council (SAMRC), and comprising the Nigerian Institute of Medical Research (NIMR), the Clinical Research Education, Networking and Consultancy (CRENC, Cameroon). Specifically we will: 1) Characterise the cardiometabolic profile of adults HIV-infected individuals at their baseline enrolment in Cameroon, using data from the Cameroon arm of the ongoing International Epidemiologic Databases to Evaluate AIDS (IeDEA). 2) Assess the incidence and remission of dyslipidemia and impaired kidney function in people with HIV on ART in Nigeria, using data from the NIMR HIV cohort. 3) Conduct a clinical trial to test the effectiveness of sending weekly SMS-text message in improving health outcomes and supporting medication adherence in South African adults with co-morbid HIV and hypertension. This will be augmented with process evaluation and cost-effectiveness analysis. 4) The three research projects in 1-3 will support the training of a PhD student in each of the three countries, and reinforce the research capacities of junior and senior researchers where appropriate.

Host Organisation

Institution Country
South African Medical Research Council South Africa

Study Design

The core component of the project is a 12-month, individually randomized controlled two-arm trial, open-labelled single blinded, to assess the effect of text messaging vs. usual care on adherence to hypertension medications and outcomes of care among adult South Africans with co-morbid HIV and hypertension. This will be augmented with process evaluation and economic analysis. The trial is based on an adaptation of the StAR trial conducted in the general population in Cape Town. A software algorithm will assigned participants independent of the research team to the intervention and control arms in a 1:1 ratio using a non-deterministic minimization algorithm to ensure balance between groups with respect to key characteristics including gender, age, baseline blood pressure and known duration of hypertension. The treatment group will receive messages to motivate collecting and taking medicine and to provide education about and motivation for secondary adherence, in particular, on healthy lifestyle choices. These messages will be sent three times a week for 52 weeks. Outcome measures will include: Primary – mean difference in SBP and DBP; Secondary – 1) uptake and adherence to BP medications; with adherence measured using the 5 item Medication Adherence Report Scale (MARS) adiminstered at baseline and at the end of the trial;, 2) uptake and adherence to HIV specific medications, 3) mean change in lipid variables, 4) mean change in CD4 count and viral load, 4) mean change in adiposity variables, 5) change in kidney function; Tertiary - 1) Descriptive analysis of the process involved in the intervention, 2) Economic analysis, 3) Quality of life. Using the standard deviation from the baseline work (18 mmHg for SBP)12 and 90% power for a 5mmHg drop in SBP in the intervention as compared to the control arm, 546 participants will be needed per study arm. Allowing for a 20% dropout rate, the total number of participants will be 1300 (650 per arm/site).

Students Supervised

Type Name Title University Start Date End Date
PhD Peter Ebasone Mr University of Cape Town 2020 2024
PhD Odubela Oluwatosin Mr University of Cape Town 2020 2024
PhD Danleen Hongoro Mr University of Cape Town 2020 2024

Publications

Odukoya OO, Ohazurike C, Akanbi M, O'Dwyer LC, Isikekpei B, Kuteyi E, Ameh IO, Osadiaye O, Adebayo K, Usinoma A, Adewole A, Odunukwe N, Okuyemi K, Kengne AP. mHealth Interventions for Treatment Adherence and Outcomes of Care for Cardiometabolic Disease Among Adults Living With HIV: Systematic Review. JMIR Mhealth Uhealth. 2021 Jun 9;9(6):e20330. doi: 10.2196/20330.
Nguyen KA, Peer N, Kengne AP. Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa. PLoS One. 2021 Feb 5;16(2):e0246131. doi: 10.1371/journal.pone.0246131. eCollection 2021.
Peer N, de Villiers A, Jonathan D, Kalombo C, Kengne AP. Care and management of a double burden of chronic diseases: Experiences of patients and perceptions of their healthcare providers. PLoS One. 2020 Jul 16;15(7):e0235710. doi: 10.1371/journal.pone.0235710. eCollection 2020.

Current Organisation

South African Medical Research Council

Current Job Title

Director, Non-Communicable Diseases Research Unit

Students Supervised

Type Name Title University Start Date End Date
PhD Peter Ebasone Mr University of Cape Town 2020 2024
PhD Odubela Oluwatosin Mr University of Cape Town 2020 2024
PhD Danleen Hongoro Mr University of Cape Town 2020 2024

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Publications

Authors:
Kengne AP , author
Libend CN , author
Dzudie A , author
Menanga A , author
Dehayem MY , author
Kingue S , author
Sobngwi E , author
Date:
2014-10-01
Journal:
The Pan African medical journal
Content:
Identifiers:
Authors:
Pheiffer C , author
Erasmus RT , author
Kengne AP , author
Matsha TE , author
Date:
2015-12-01
Journal:
Clinical biochemistry
Content:
Authors:
Yako YY , author
Madubedube JH , author
Kengne AP , author
Erasmus RT , author
Pillay TS , author
Matsha TE , author
Date:
2015-12-01
Journal:
African health sciences
Content:
Identifiers:
Authors:
Kufe NC , author
Masemola M , author
Chikowore T , author
Kengne AP , author
Olsson T , author
Goedecke JH , author
Micklesfield LK , author
Date:
2019-01-01
Journal:
BMJ open
Content:
Identifiers:
Authors:
GACD Hypertension Research Programme , author
Writing Group , author
Peiris D , author
Thompson SR , author
Beratarrechea A , author
Cárdenas MK , author
Diez-Canseco F , author
Goudge J , author
Gyamfi J , author
Hypertension Research Programme members , author
Date:
2015-11-01
Journal:
Implementation science : IS
Content:
Identifiers:
Authors:
Kaze FF , author
Ashuntantang G , author
Kengne AP , author
Hassan A , author
Halle MP , author
Muna W , author
Date:
2012-04-01
Journal:
Hemodialysis international. International Symposium on Home Hemodialysis
Content:
Identifiers:
Authors:
Nouya AY , author
Nansseu JR , author
Moor VJ , author
Pieme CA , author
Noubiap JJ , author
Tchoula CM , author
Mokette BM , author
Takam RD , author
Tankeu F , author
Ngogang JY , author
Kengne AP , author
Date:
2014-10-01
Journal:
Diabetes research and clinical practice
Content:
Identifiers:
Authors:
Kengne AP , author
Dzudie A , author
Dongmo L , author
Date:
2006-10-01
Journal:
Neuroepidemiology
Content:
Identifiers:
Authors:
Mazidi M , author
Heidari-Bakavoli A , author
Khayyatzadeh SS , author
Azarpazhooh MR , author
Nematy M , author
Safarian M , author
Esmaeili H , author
Parizadeh SM , author
Ghayour-Mobarhan M , author
Kengne AP , author
Ferns GA , author
Date:
2016-09-01
Journal:
European journal of clinical nutrition
Content:
Identifiers:
Authors:
Werfalli M , author
Raubenheimer PJ , author
Engel M , author
Musekiwa A , author
Bobrow K , author
Peer N , author
Hoegfeldt C , author
Kalula S , author
Kengne AP , author
Levitt NS , author
Date:
2020-06-01
Journal:
Systematic reviews
Content:
Identifiers:
Authors:
Andre Pascal Kengne , author
Eugene Sobngwi , author
Leopold Fezeu , author
Paschal Kum Awah , author
Sylvestre Dongmo , author
Date:
Journal:
Content:
Setting-up nurse-led pilot clinics for the management of non-communicable diseases at primary health care level in resource-limited settings of Africa
Authors:
Nong-Libend C , author
Menanga AP , author
Kengne AP , author
Dehayem M , author
Sobngwi E , author
Kingue S , author
Date:
2012-05-01
Journal:
Diabetes & metabolism
Content:
Identifiers:
Authors:
Echouffo-Tcheugui JB , author
Kengne AP , author
Ali MK , author
Date:
2018-09-01
Journal:
Current diabetes reports
Content:
Identifiers:
Authors:
Kaze FF , author
Meto DT , author
Halle MP , author
Ngogang J , author
Kengne AP , author
Date:
2015-07-01
Journal:
BMC nephrology
Content:
Identifiers:
Authors:
Theodosia Adom , author
Anniza De Villiers , author
Thandi Puoane , author
André Pascal Kengne , author
Date:
2019-01-01
Journal:
Content:
Abstract Background There is limited data on risk factors associated with childhood overweight and obesity in Ghanaian school children. Therefore, the aim of this study was to assess the prevalence of overweight and obesity and associated risk factors in Ghanaian school children. Methods Data for this study were obtained from a cross-sectional survey of 543 children aged 8 and 11 years, attending private and public primary schools in the Adentan Municipality of Greater Accra Region, Ghana. Anthropometric, dietary, physical activity, sedentary behaviours, sleep duration and socio-demographic data were collected. BMI-for-age Z-scores were used to classify children as overweight/obesity. Multivariable logistic regressions were used to assess the determinants of overweight and obesity. Results The overall prevalence of overweight/obesity was 16.4%. Children living in middle (OR = 1.88; 95% CI = 1.01–3.50) and high socioeconomic status (SES) households (2.58; 1.41–4.70) had increased odds of being overweight or obese compared to those living in low SES household. Attending private school (2.44; 1.39–4.29) and watching television for more than 2 h each day (1.72; 1.05–2.82) were significantly associated with increased likelihood of overweight and obesity. Children who slept for more than 9 h a night (0.53; 0.31–0.88) and walked or cycled to school (0.51; 0.31–0.82) had lower odds of being overweight or obese. Conclusions A number of modifiable risk factors were associated with overweight and obesity in this study. Public health strategies to prevent childhood obesity should target reduction in television watching time, promoting active transport to and from school, and increasing sleep duration.
Authors:
Mbanya V , author
Hussain A , author
Kengne AP , author
Date:
2015-05-01
Journal:
Primary care diabetes
Content:
Identifiers:
Authors:
Pule GD , author
Ngo Bitoungui VJ , author
Chetcha Chemegni B , author
Kengne AP , author
Wonkam A , author
Date:
2016-11-01
Journal:
Hemoglobin
Content:
Identifiers:
Authors:
Feigin VL , author
Krishnamurthi RV , author
Parmar P , author
Norrving B , author
Mensah GA , author
Bennett DA , author
Barker-Collo S , author
Moran AE , author
Sacco RL , author
Truelsen T , author
Davis S , author
Pandian JD , author
GBD 2013 Stroke Panel Experts Group , author
Date:
2015-10-01
Journal:
Neuroepidemiology
Content:
Identifiers:
Authors:
Kengne AP , author
Sobngwi E , author
Echouffo-Tcheugui JB , author
Mbanya JC , author
Date:
2013-05-01
Journal:
Heart (British Cardiac Society)
Content:
Identifiers:
Authors:
Mazidi M , author
Kengne AP , author
Sahebkar A , author
Banach M , author
Date:
2017-06-01
Journal:
Angiology
Content:
Identifiers:
Authors:
Date:
2005-10-28
Journal:
International journal of epidemiology
Content:
BACKGROUND: As the relation between socioeconomic status (SES) and obesity may depend on the stage of development of a country, this relation is assessed in adults from urban Cameroon. METHODS: A sample comprising 1530 women and 1301 men aged 25 years and above, from 1897 households in the Biyem-Assi health area in the capital of Cameroon, Yaoundé, were interviewed about their household amenities, occupation, and education. Weight, height, and waist circumference were measured and subjects were classified as obese if their BMI>or=30 kg/m2 or overweight if BMI was between 25.0 and 29.9 kg/m2. Abdominal obesity was defined by a waist circumference>or=80 cm in women and>or=94 cm in men. RESULTS: Of the sample studied 33% of women and 30% of men were overweight (P<0.08), whereas 22% of women and 7% of men were obese (P<0.001). Abdominal obesity was present in 67% of women and 18% of men (P<0.001). After adjusting for age, leisure time physical activity, alcohol consumption, and tobacco smoking, the prevalence of overweight+obesity, obesity, and abdominal obesity increased with quartiles of household amenities in both genders and with occupational level in men. CONCLUSION: SES is positively associated with adiposity in urban Cameroon after adjusting for confounding factors.
Identifiers:
Authors:
Marie Patrice Halle , author
Gloria Ashuntantang , author
Francois Folefack Kaze , author
Christian Takongue , author
Andre-Pascal Kengne , author
Date:
2016-12-01
Journal:
BMC Nephrology
Content:
Identifiers:
Authors:
Boateng D , author
Agyemang C , author
Beune E , author
Meeks K , author
Smeeth L , author
Schulze M , author
Addo J , author
de-Graft Aikins A , author
Galbete C , author
Bahendeka S , author
Danquah I , author
Agyei-Baffour P , author
Klipstein-Grobusch K , author
Date:
2017-11-01
Journal:
Circulation. Cardiovascular quality and outcomes
Content:
Identifiers:
Authors:
Matsha TE , author
Hartnick MD , author
Kisten Y , author
Eramus RT , author
Kengne AP , author
Date:
2013-10-01
Journal:
Journal of diabetes
Content:
Identifiers:
Authors:
Mazidi M , author
Kengne AP , author
George ES , author
Siervo M , author
Date:
2019-08-01
Journal:
The British journal of nutrition
Content:
Identifiers:
Authors:
Katte JC , author
Dzudie A , author
Sobngwi E , author
Mbong EN , author
Fetse GT , author
Kouam CK , author
Kengne AP , author
Date:
2014-07-01
Journal:
BMC public health
Content:
Identifiers:
Authors:
Alain Lekoubou , author
Clovis Nkoke , author
Anastase Dudzie , author
Andre Pascal Kengne , author
Date:
2016-01-01
Journal:
Content:
Background: Despite the increasing availability of head computerized tomography (CT) in resource-limited settings, it is unclear if brain-imaging-based diagnosis of stroke affects the outcomes in the absence of dedicated structures for acute stroke management. Objectives: In a major referral hospital in the capital city of Cameroon, we compared in-hospital mortality rates in patients with a WHO-based diagnosis of stroke between participants with and without brain imaging on admission. Methods: Stroke patients with and without admission brain imaging were compared for demographic characteristics, risk factors, clinical and laboratory characteristic, and in-hospital mortality. Heterogeneities in mortality rates (CT vs. No CT) across major subgroups were investigated via interaction tests, and logistic regressions used to adjust for extraneous factors such as age, sex, year of study, residency, history of diabetes and hypertension, history of stroke, Glasgow coma scale, and delay between stroke symptoms onset and hospital admission. Results: Of the 1688 participants included in the final analysis, 1048 (62.1%) had brain imaging. The median age of the non-CT vs. CT groups was 65 vs. 62 years (p-value < 0.0001%). The death rate of non-CT vs. CT groups was 27.5% vs. 16.4% (p < 0.0001). This difference was mostly similar across major subgroups, and robust to the adjustments for confounders (in spite of substantial attenuation), with excess deaths in those with CT ranging from 65% to 149%. Conclusion: In this resource-limited environment, the absence of brain imaging on admission was associated with high in-hospital death from stroke, which was only partially explained by delayed hospitalization with severe disease. These results stressed the importance of scaling up acute stroke management in low- and middle-income countries.
Authors:
Pefura Yone EW , author
Kuaban C , author
Kengne AP , author
Date:
2012-08-01
Journal:
BMC infectious diseases
Content:
Identifiers:
Authors:
Zemlin AE , author
Matsha TE , author
Kengne AP , author
Hon GM , author
Erasmus RT , author
Date:
2016-09-01
Journal:
Annals of clinical biochemistry
Content:
Identifiers:
Authors:
Engel ME , author
Cohen K , author
Gounden R , author
Kengne AP , author
Barth DD , author
Whitelaw AC , author
Francis V , author
Badri M , author
Stewart A , author
Dale JB , author
Mayosi BM , author
Maartens G , author
Date:
2017-03-01
Journal:
The Pediatric infectious disease journal
Content:
Identifiers:
Authors:
GBD 2017 Inflammatory Bowel Disease Collaborators , author
Date:
2019-10-01
Journal:
The lancet. Gastroenterology & hepatology
Content:
Identifiers:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
Hassan Vatanparast , author
Date:
2017-01-01
Journal:
Oxidative Medicine and Cellular Longevity
Content:
Identifiers:
Authors:
Uthman OA , author
Nduka C , author
Watson SI , author
Mills EJ , author
Kengne AP , author
Jaffar SS , author
Clarke A , author
Moradi T , author
Ekström AM , author
Lilford R , author
Date:
2018-06-01
Journal:
BMC infectious diseases
Content:
Identifiers:
Authors:
NCD Risk Factor Collaboration (NCD-RisC) , author
Date:
2019-05-01
Journal:
Nature
Content:
Identifiers:
Authors:
Steve Raoul Ngongang Noumegni , author
Jobert Richie Nansseu , author
Vicky Jocelyne Moor Ama , author
Jean Joel Bigna , author
Felix Kembe Assah , author
Magellan Guewo-Fokeng , author
Steve Leumi , author
Jean-Claude Katte , author
Mesmin Dehayem , author
Andre Pascal Kengne , author
Eugene Sobngwi , author
Date:
2017-01-01
Journal:
Content:
Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. Results We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10–4.72). Conclusion Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.
Authors:
Andre Pascal Kengne , author
Anushka Patel , author
Date:
2006-01-01
Journal:
Content:
Authors:
Kuguyo O , author
Kengne AP , author
Dandara C , author
Date:
2020-06-01
Journal:
Omics : a journal of integrative biology
Content:
Identifiers:
Authors:
Mohsen Mazidi , author
Andre Pascal Kengne , author
Dimitri P. Mikhailidis , author
Arrigo F. Cicero , author
Maciej Banach , author
Date:
2017-01-01
Journal:
Content:
Abstract ; Background and aim: Growing evidence suggests that some of the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed the relationship between selected dietary constituents and serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of United States adults. Methods: In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010. All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). Results: Of the 17,689 participants analysed, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample, 44.9 in men and 46.5 in women ( p = .047). The age-, race-, sex-, energy intake- and body mass index-adjusted mean dietary intakes of total dietary fibre, polyunsaturated fatty-acids, vitamin E, vitamin A, vitamin B6, total folate, vitamin B family, vitamin C, vitamin K, magnesium, iron, copper and potassium monotonically decreased across increasing hsCRP quarters ( p < .001 for all), whereas sugar intake increased ( p < .001). In analysis of covariance adjusted for potential confounders (age-, race-, sex-, energy intake- and body weight-) hsCRP levels increased across increasing quarters of sugar intake ( p < .001). Conclusions: This study provides further evidence of an association between dietary sugar, polyunsaturated fatty-acids, fibre and antioxidant intake and hsCRP levels, a subclinical inflammation marker. hsCRP concentrations are likely modulated by dietary intake.KEY MESSAGES Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake. Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake.
Authors:
Dzudie A , author
Rayner B , author
Ojji D , author
Schutte AE , author
Twagirumukiza M , author
Damasceno A , author
Ba SA , author
Kane A , author
Kramoh E , author
Anzouan Kacou JB , author
Onwubere B , author
Cornick R , author
Sliwa K , author
PASCAR Task Force on Hypertension , author
Date:
2017-10-01
Journal:
Global heart
Content:
Identifiers:
Authors:
Balti EV , author
Kengne AP , author
Fokouo JVF , author
Nouthé BE , author
Sobngwi E , author
Date:
2013-12-01
Journal:
PloS one
Content:
Authors:
Chalmers J , author
Kengne AP , author
Joshi R , author
Perkovic V , author
Patel A , author
Date:
2007-06-01
Journal:
Journal of hypertension. Supplement : official journal of the International Society of Hypertension
Content:
Authors:
Moloi MW , author
Kajawo S , author
Noubiap JJ , author
Mbah IO , author
Ekrikpo U , author
Kengne AP , author
Bello AK , author
Okpechi IG , author
Date:
2018-05-01
Journal:
BMJ open
Content:
Identifiers:
Authors:
Lekoubou A , author
Philippeau F , author
Derex L , author
Olaru A , author
Gouttard M , author
Vieillart A , author
Kengne AP , author
Date:
2013-12-01
Journal:
Neurological research
Content:
Identifiers:
Authors:
Matsha TE , author
Hassan MS , author
Hon GM , author
Soita DJ , author
Kengne AP , author
Erasmus RT , author
Date:
2013-05-01
Journal:
International journal of cardiology
Content:
Identifiers:
Authors:
Matsha TE , author
Kengne AP , author
Masconi KL , author
Yako YY , author
Erasmus RT , author
Date:
2015-06-01
Journal:
BMC genetics
Content:
Identifiers:
Authors:
Matsha TE , author
Yako YY , author
Rensburg MA , author
Hassan MS , author
Kengne AP , author
Erasmus RT , author
Date:
2013-04-01
Journal:
BMC nephrology
Content:
Identifiers:
Authors:
Mazidi M , author
Shivappa N , author
Wirth MD , author
Hebert JR , author
Kengne AP , author
Date:
2018-11-01
Journal:
European journal of clinical nutrition
Content:
Identifiers:
Authors:
Eric Walter Pefura-Yone , author
André Pascal Kengne , author
Emmanuel Afane-Ze , author
Christopher Kuaban , author
Date:
Journal:
Content:
Background German cockroach or Blattella germanica is commonly found in homes across the inter-tropical region. The contribution of sensitisation to Blattella germanica in people with asthma in sub-Saharan Africa has not received attention. The aim of this study was to assess the prevalence and investigate the predicting factors of sensitisation to Blattella germanica in patients with asthma in Yaounde, Cameroon.Methods This was a cross-sectional study conducted between January 2012 and June 2013. All patients (aged 15 years and above) with asthma, receiving care at the Yaounde Jamot Hospital and the CEDIMER medical practice during the study period and who had received a prick skin testing for perennial aeroallergens were included in the study.Results The final sample comprised 184 patients including 123 (66.8%) women. The median age (25th-75th percentiles) was 38 (24–54) years. Prick skin test for Blattella germanica was positive in 47 (25.5%) patients. Sensitisation to Blattella germanica was associated with a sensitisation to mite in 41 (87.2%) patients, a sensitisation to Alternaria in 18 (38.3%) patients, and a sensitisation to cat or dog dander in 7 (14.9%) patients. Independent predicting factors of a sensitisation to Blattella germanica were the sensitisation to Blomia tropicalis [adjusted odd ratio (95% confidence interval) 4.10 (1.67-10.04), p = 0.002] and sensitisation to Alternaria [3.67 (1.53-7.46), p = 0.003].Conclusions Sensitisation to Blattella germanica is present in about a quarter of adult patients with asthma in Yaounde. Sensitisation to Alternaria and Blomia tropicalis appears to be a powerful predicting factor of sensitisation to Blattella germanica in this setting. Keywords: Asthma, Blattella, Allergy, Aeroallergens, Africa
Authors:
Eric Walter Pefura-Yone , author
Emmanuel Soh , author
André Pascal Kengne , author
Adamou Dodo Balkissou , author
Christopher Kuaban , author
Date:
2013-01-01
Journal:
Content:
Summary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31–0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14–2.28)], Pentecostal Christianity [2.18 (1.25–3.80)], alcohol consumption [1.65 (1.16–2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92–8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19–2.12)], [1.83 (1.36–2.47)], [1.70 (1.27–2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17–2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. Keywords: Antiretroviral therapy, Adherence, HIV infection, Cameroon
Authors:
Riddell MA , author
Edwards N , author
Thompson SR , author
Bernabe-Ortiz A , author
Praveen D , author
Johnson C , author
Kengne AP , author
Liu P , author
McCready T , author
Ng E , author
Nieuwlaat R , author
Ovbiagele B , author
Owolabi M , author
GACD Hypertension Research Programme , author
Date:
2017-03-01
Journal:
Globalization and health
Content:
Identifiers:
Authors:
GBD 2017 Gastro-oesophageal Reflux Disease Collaborators , author
Date:
2020-03-01
Journal:
The lancet. Gastroenterology & hepatology
Content:
Identifiers:
Authors:
Ataklte F , author
Erqou S , author
Kaptoge S , author
Taye B , author
Echouffo-Tcheugui JB , author
Kengne AP , author
Date:
2014-11-01
Journal:
Hypertension (Dallas, Tex. : 1979)
Content:
Authors:
Wang H , author
Liddell CA , author
Coates MM , author
Mooney MD , author
Levitz CE , author
Schumacher AE , author
Apfel H , author
Iannarone M , author
Phillips B , author
Lofgren KT , author
Sandar L , author
Dorrington RE , author
Rakovac I , author
Murray CJ , author
Date:
2014-05-01
Journal:
Lancet (London, England)
Content:
Identifiers:
Authors:
Odukoya OO , author
Ohazurike C , author
Akanbi M , author
O'Dwyer LC , author
Isikekpei B , author
Kuteyi E , author
Ameh IO , author
Osadiaye O , author
Adebayo K , author
Usinoma A , author
Adewole A , author
Odunukwe N , author
Okuyemi K , author
Kengne AP , author
Date:
2021-06-01
Journal:
JMIR mHealth and uHealth
Content:
Identifiers:
PMID: 34106075
DOI: 10.2196/20330
Authors:
Kaze FF , author
Kengne AP , author
Atanga LC , author
Monny Lobe M , author
Menanga AP , author
Halle MP , author
Chetcha Chemegni B , author
Ngo Sack F , author
Kingue S , author
Ashuntantang G , author
Date:
2012-10-01
Journal:
Clinical kidney journal
Content:
Identifiers:
Authors:
GBD 2020 , author
Release 1 , author
Vaccine Coverage Collaborators , author
Date:
2021-07-01
Journal:
Lancet (London, England)
Content:
Identifiers:
Authors:
Fezeu LK , author
Assah FK , author
Balkau B , author
Mbanya DS , author
Kengne AP , author
Awah PK , author
Mbanya JC , author
Date:
2008-03-01
Journal:
Obesity (Silver Spring, Md.)
Content:
Identifiers:
Authors:
Kengne AP , author
Dzudie AI , author
Fezeu LL , author
Mbanya JC , author
Date:
2006-03-01
Journal:
The international journal of lower extremity wounds
Content:
Identifiers:
Authors:
Kengne AP , author
Awah PK , author
Fezeu L , author
Mbanya JC , author
Date:
2007-03-01
Journal:
African health sciences
Content:
Identifiers:
Authors:
Vergotine Z , author
Kengne AP , author
Erasmus RT , author
Yako YY , author
Matsha TE , author
Date:
2014-08-01
Journal:
International journal of endocrinology
Content:
Identifiers:
Authors:
Aminde LN , author
Takah NF , author
Noubiap JJ , author
Tindong M , author
Ngwasiri C , author
Jingi AM , author
Kengne AP , author
Dzudie A , author
Date:
2015-11-01
Journal:
BMC public health
Content:
Identifiers:
Authors:
Moons KG , author
Kengne AP , author
Woodward M , author
Royston P , author
Vergouwe Y , author
Altman DG , author
Grobbee DE , author
Date:
2012-03-01
Journal:
Heart (British Cardiac Society)
Content:
Identifiers:
Authors:
van Dieren S , author
Kengne AP , author
Chalmers J , author
Beulens JW , author
Cooper ME , author
Grobbee DE , author
Harrap S , author
Mancia G , author
Neal B , author
Patel A , author
Poulter N , author
van der Schouw YT , author
Woodward M , author
Zoungas S , author
Date:
2012-06-01
Journal:
Diabetes research and clinical practice
Content:
Identifiers:
Authors:
GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators , author
Date:
2018-11-01
Journal:
The Lancet. Neurology
Content:
Identifiers:
Authors:
Eric Vounsia Balti , author
André Pascal Kengne , author
Jean Valentin Fogha Fokouo , author
Brice Enid Nouthé , author
Eugene Sobngwi , author
Date:
Journal:
Content:
BACKGROUND AND PURPOSE: Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa). METHODS: Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment. RESULTS: Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p≤0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p = 0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p = 0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset. CONCLUSION: The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.
Authors:
Carmen Pheiffer , author
Victoria Pillay-van Wyk , author
Eunice Turawa , author
Naomi Levitt , author
Andre P. Kengne , author
Debbie Bradshaw , author
Date:
2021-05-30
Journal:
International Journal of Environmental Research and Public Health
Content:
Identifiers:
Authors:
Di Cesare M , author
Sorić M , author
Bovet P , author
Miranda JJ , author
Bhutta Z , author
Stevens GA , author
Laxmaiah A , author
Kengne AP , author
Bentham J , author
Date:
2019-11-01
Journal:
BMC medicine
Content:
Identifiers:
Authors:
Muyunda Mutemwa , author
Nasheeta Peer , author
Anniza De Villiers , author
Mieke Faber , author
Andre-Pascal Kengne , author
Date:
2020-04-21
Journal:
Southern African Journal of HIV Medicine
Content:
Identifiers:
Authors:
Peer N , author
Naicker A , author
Khan M , author
Kengne AP , author
Date:
2020-07-01
Journal:
SAGE open medicine
Content:
Identifiers:
Authors:
Anastase, Dzudie , author
Suiru, Dzekem , author
Andre, Pascal Kengne , author
Date:
2017-01-01
Journal:
Content:
Authors:
Macharia M , author
Kengne AP , author
Blackhurst DM , author
Erasmus RT , author
Matsha TE , author
Date:
2013-07-01
Journal:
Journal of clinical pathology
Content:
Identifiers:
Authors:
NCD Risk Factor Collaboration (NCD-RisC) , author
Date:
2020-06-01
Journal:
Nature
Content:
Identifiers:
Authors:
Kuate-Tegueu C , author
Temfack E , author
Ngankou S , author
Doumbe J , author
Djientcheu VP , author
Kengne AP , author
Date:
2015-05-01
Journal:
Journal of the neurological sciences
Content:
Identifiers:
Authors:
Davidson FE , author
Matsha TE , author
Erasmus RT , author
Ismail S , author
Kengne AP , author
Goedecke JH , author
Date:
2020-04-01
Journal:
European journal of clinical nutrition
Content:
Identifiers:
Authors:
Davids SF , author
Matsha TE , author
Peer N , author
Erasmus RT , author
Kengne AP , author
Date:
2019-11-01
Journal:
Frontiers in endocrinology
Content:
Identifiers:
Authors:
Kuate D , author
Kengne AP , author
Biapa CP , author
Azantsa BG , author
Abdul Manan Bin Wan Muda W , author
Date:
2015-05-01
Journal:
Lipids in health and disease
Content:
Identifiers:
Authors:
Kengne AP , author
Czernichow S , author
Huxley R , author
Grobbee D , author
Woodward M , author
Neal B , author
Zoungas S , author
Cooper M , author
Glasziou P , author
Hamet P , author
Harrap SB , author
Mancia G , author
Poulter N , author
ADVANCE Collaborative Group , author
Date:
2009-05-01
Journal:
Hypertension (Dallas, Tex. : 1979)
Content:
Authors:
Davidson FE , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Goedecke JH , author
Date:
2019-11-01
Journal:
Diabetology & metabolic syndrome
Content:
Identifiers:
Authors:
Peprah E , author
Armstrong-Hough M , author
Cook S , author
Mukasa B , author
Taylor J , author
Xu H , author
Chang L , author
Gyamfi J , author
Ryan N , author
Ojo T , author
Snyder A , author
Iwelunmor J , author
Ezechi O , author
Iyegbe C , author
Pascal Kengne A , author
Date:
2021-03-01
Journal:
International journal of environmental research and public health
Content:
Identifiers:
PMC: PMC8003038
Authors:
Kengne AP , author
Dzudie A , author
Sobngwi E , author
Date:
2008-01-01
Journal:
Vascular health and risk management
Content:
Identifiers:
Authors:
Yone EW , author
Balkissou AD , author
Kengne AP , author
Kuaban C , author
Date:
2012-08-01
Journal:
BMC pulmonary medicine
Content:
Identifiers:
Authors:
Adom T , author
Puoane T , author
De Villiers A , author
Kengne AP , author
Date:
2017-02-01
Journal:
BMJ open
Content:
Identifiers:
Authors:
Gary Maartens , author
Annemie Stewart , author
Rulan Griesel , author
Andre P. Kengne , author
Felix Dube , author
Mark Nicol , author
Molebogeng X. Rangaka , author
Marc Mendelson , author
Date:
2018-07-23
Journal:
Southern African Journal of HIV Medicine
Content:
Identifiers:
Authors:
Masoud M , author
Kengne AP , author
Erasmus RT , author
Hon GM , author
Macharia M , author
Matsha TE , author
Date:
2018-03-01
Journal:
Indian journal of clinical biochemistry : IJCB
Content:
Identifiers:
Authors:
Dzudie A , author
Choukem SP , author
Dehayem MY , author
Kengne AP , author
Date:
2012-12-01
Journal:
Journal of diabetes
Content:
Identifiers:
Authors:
Thomas B , author
Matsushita K , author
Abate KH , author
Al-Aly Z , author
Ärnlöv J , author
Asayama K , author
Atkins R , author
Badawi A , author
Ballew SH , author
Banerjee A , author
Barregård L , author
Barrett-Connor E , author
Basu S , author
Global Burden of Disease Genitourinary Expert Group , author
Date:
2017-04-01
Journal:
Journal of the American Society of Nephrology : JASN
Content:
Identifiers: