EDCTP Alumni Network

Kengne AP , author
Libend CN , author
Dzudie A , author
Menanga A , author
Dehayem MY , author
Kingue S , author
Sobngwi E , author

2014-10-01

The Pan African medical journal

Pheiffer C , author
Erasmus RT , author
Kengne AP , author
Matsha TE , author

2015-12-01

Clinical biochemistry

Yako YY , author
Madubedube JH , author
Kengne AP , author
Erasmus RT , author
Pillay TS , author
Matsha TE , author

2015-12-01

African health sciences

Kufe NC , author
Masemola M , author
Chikowore T , author
Kengne AP , author
Olsson T , author
Goedecke JH , author
Micklesfield LK , author

2019-01-01

BMJ open

GACD Hypertension Research Programme , author
Writing Group , author
Peiris D , author
Thompson SR , author
Beratarrechea A , author
Cárdenas MK , author
Diez-Canseco F , author
Goudge J , author
Gyamfi J , author
Hypertension Research Programme members , author

2015-11-01

Implementation science : IS

Cindy George , author
Tandi E Matsha , author
Saarah FG Davids , author
Gloudina M Hon , author
U Chikte , author
Rajiv T Erasmus , author
Andre P Kengne , author

2022-03-08

South African Dental Journal

Kaze FF , author
Ashuntantang G , author
Kengne AP , author
Hassan A , author
Halle MP , author
Muna W , author

2012-04-01

Hemodialysis international. International Symposium on Home Hemodialysis

Nouya AY , author
Nansseu JR , author
Moor VJ , author
Pieme CA , author
Noubiap JJ , author
Tchoula CM , author
Mokette BM , author
Takam RD , author
Tankeu F , author
Ngogang JY , author
Kengne AP , author

2014-10-01

Diabetes research and clinical practice

Kengne AP , author
Dzudie A , author
Dongmo L , author

2006-10-01

Neuroepidemiology

Mazidi M , author
Heidari-Bakavoli A , author
Khayyatzadeh SS , author
Azarpazhooh MR , author
Nematy M , author
Safarian M , author
Esmaeili H , author
Parizadeh SM , author
Ghayour-Mobarhan M , author
Kengne AP , author
Ferns GA , author

2016-09-01

European journal of clinical nutrition

Werfalli M , author
Raubenheimer PJ , author
Engel M , author
Musekiwa A , author
Bobrow K , author
Peer N , author
Hoegfeldt C , author
Kalula S , author
Kengne AP , author
Levitt NS , author

2020-06-01

Systematic reviews

Andre Pascal Kengne , author
Eugene Sobngwi , author
Leopold Fezeu , author
Paschal Kum Awah , author
Sylvestre Dongmo , author

Setting-up nurse-led pilot clinics for the management of non-communicable diseases at primary health care level in resource-limited settings of Africa

Nong-Libend C , author
Menanga AP , author
Kengne AP , author
Dehayem M , author
Sobngwi E , author
Kingue S , author

2012-05-01

Diabetes & metabolism

Echouffo-Tcheugui JB , author
Kengne AP , author
Ali MK , author

2018-09-01

Current diabetes reports

Kaze FF , author
Meto DT , author
Halle MP , author
Ngogang J , author
Kengne AP , author

2015-07-01

BMC nephrology

Theodosia Adom , author
Anniza De Villiers , author
Thandi Puoane , author
André Pascal Kengne , author

2019-01-01

Abstract Background There is limited data on risk factors associated with childhood overweight and obesity in Ghanaian school children. Therefore, the aim of this study was to assess the prevalence of overweight and obesity and associated risk factors in Ghanaian school children. Methods Data for this study were obtained from a cross-sectional survey of 543 children aged 8 and 11 years, attending private and public primary schools in the Adentan Municipality of Greater Accra Region, Ghana. Anthropometric, dietary, physical activity, sedentary behaviours, sleep duration and socio-demographic data were collected. BMI-for-age Z-scores were used to classify children as overweight/obesity. Multivariable logistic regressions were used to assess the determinants of overweight and obesity. Results The overall prevalence of overweight/obesity was 16.4%. Children living in middle (OR = 1.88; 95% CI = 1.01–3.50) and high socioeconomic status (SES) households (2.58; 1.41–4.70) had increased odds of being overweight or obese compared to those living in low SES household. Attending private school (2.44; 1.39–4.29) and watching television for more than 2 h each day (1.72; 1.05–2.82) were significantly associated with increased likelihood of overweight and obesity. Children who slept for more than 9 h a night (0.53; 0.31–0.88) and walked or cycled to school (0.51; 0.31–0.82) had lower odds of being overweight or obese. Conclusions A number of modifiable risk factors were associated with overweight and obesity in this study. Public health strategies to prevent childhood obesity should target reduction in television watching time, promoting active transport to and from school, and increasing sleep duration.

Mbanya V , author
Hussain A , author
Kengne AP , author

2015-05-01

Primary care diabetes

Pule GD , author
Ngo Bitoungui VJ , author
Chetcha Chemegni B , author
Kengne AP , author
Wonkam A , author

2016-11-01

Hemoglobin

Feigin VL , author
Krishnamurthi RV , author
Parmar P , author
Norrving B , author
Mensah GA , author
Bennett DA , author
Barker-Collo S , author
Moran AE , author
Sacco RL , author
Truelsen T , author
Davis S , author
Pandian JD , author
GBD 2013 Stroke Panel Experts Group , author

2015-10-01

Neuroepidemiology

Kengne AP , author
Sobngwi E , author
Echouffo-Tcheugui JB , author
Mbanya JC , author

2013-05-01

Heart (British Cardiac Society)

Mazidi M , author
Kengne AP , author
Sahebkar A , author
Banach M , author

2017-06-01

Angiology

2005-10-28

International journal of epidemiology

BACKGROUND: As the relation between socioeconomic status (SES) and obesity may depend on the stage of development of a country, this relation is assessed in adults from urban Cameroon. METHODS: A sample comprising 1530 women and 1301 men aged 25 years and above, from 1897 households in the Biyem-Assi health area in the capital of Cameroon, Yaoundé, were interviewed about their household amenities, occupation, and education. Weight, height, and waist circumference were measured and subjects were classified as obese if their BMI>or=30 kg/m2 or overweight if BMI was between 25.0 and 29.9 kg/m2. Abdominal obesity was defined by a waist circumference>or=80 cm in women and>or=94 cm in men. RESULTS: Of the sample studied 33% of women and 30% of men were overweight (P<0.08), whereas 22% of women and 7% of men were obese (P<0.001). Abdominal obesity was present in 67% of women and 18% of men (P<0.001). After adjusting for age, leisure time physical activity, alcohol consumption, and tobacco smoking, the prevalence of overweight+obesity, obesity, and abdominal obesity increased with quartiles of household amenities in both genders and with occupational level in men. CONCLUSION: SES is positively associated with adiposity in urban Cameroon after adjusting for confounding factors.

Marie Patrice Halle , author
Gloria Ashuntantang , author
Francois Folefack Kaze , author
Christian Takongue , author
Andre-Pascal Kengne , author

2016-12-01

BMC Nephrology

GBD 2017 Oesophageal Cancer Collaborators , author

2020-04-01

The lancet. Gastroenterology & hepatology

Boateng D , author
Agyemang C , author
Beune E , author
Meeks K , author
Smeeth L , author
Schulze M , author
Addo J , author
de-Graft Aikins A , author
Galbete C , author
Bahendeka S , author
Danquah I , author
Agyei-Baffour P , author
Klipstein-Grobusch K , author

2017-11-01

Circulation. Cardiovascular quality and outcomes

Matsha TE , author
Hartnick MD , author
Kisten Y , author
Eramus RT , author
Kengne AP , author

2013-10-01

Journal of diabetes

Mazidi M , author
Kengne AP , author
George ES , author
Siervo M , author

2019-08-01

The British journal of nutrition

Katte JC , author
Dzudie A , author
Sobngwi E , author
Mbong EN , author
Fetse GT , author
Kouam CK , author
Kengne AP , author

2014-07-01

BMC public health

Alain Lekoubou , author
Clovis Nkoke , author
Anastase Dudzie , author
Andre Pascal Kengne , author

2016-01-01

Background: Despite the increasing availability of head computerized tomography (CT) in resource-limited settings, it is unclear if brain-imaging-based diagnosis of stroke affects the outcomes in the absence of dedicated structures for acute stroke management. Objectives: In a major referral hospital in the capital city of Cameroon, we compared in-hospital mortality rates in patients with a WHO-based diagnosis of stroke between participants with and without brain imaging on admission. Methods: Stroke patients with and without admission brain imaging were compared for demographic characteristics, risk factors, clinical and laboratory characteristic, and in-hospital mortality. Heterogeneities in mortality rates (CT vs. No CT) across major subgroups were investigated via interaction tests, and logistic regressions used to adjust for extraneous factors such as age, sex, year of study, residency, history of diabetes and hypertension, history of stroke, Glasgow coma scale, and delay between stroke symptoms onset and hospital admission. Results: Of the 1688 participants included in the final analysis, 1048 (62.1%) had brain imaging. The median age of the non-CT vs. CT groups was 65 vs. 62 years (p-value < 0.0001%). The death rate of non-CT vs. CT groups was 27.5% vs. 16.4% (p < 0.0001). This difference was mostly similar across major subgroups, and robust to the adjustments for confounders (in spite of substantial attenuation), with excess deaths in those with CT ranging from 65% to 149%. Conclusion: In this resource-limited environment, the absence of brain imaging on admission was associated with high in-hospital death from stroke, which was only partially explained by delayed hospitalization with severe disease. These results stressed the importance of scaling up acute stroke management in low- and middle-income countries.

Pefura Yone EW , author
Kuaban C , author
Kengne AP , author

2012-08-01

BMC infectious diseases

Zemlin AE , author
Matsha TE , author
Kengne AP , author
Hon GM , author
Erasmus RT , author

2016-09-01

Annals of clinical biochemistry

Engel ME , author
Cohen K , author
Gounden R , author
Kengne AP , author
Barth DD , author
Whitelaw AC , author
Francis V , author
Badri M , author
Stewart A , author
Dale JB , author
Mayosi BM , author
Maartens G , author

2017-03-01

The Pediatric infectious disease journal

GBD 2017 Inflammatory Bowel Disease Collaborators , author

2019-10-01

The lancet. Gastroenterology & hepatology

Mohsen Mazidi , author
Andre Pascal Kengne , author
Hassan Vatanparast , author

2017-01-01

Oxidative Medicine and Cellular Longevity

Uthman OA , author
Nduka C , author
Watson SI , author
Mills EJ , author
Kengne AP , author
Jaffar SS , author
Clarke A , author
Moradi T , author
Ekström AM , author
Lilford R , author

2018-06-01

BMC infectious diseases

NCD Risk Factor Collaboration (NCD-RisC) , author

2019-05-01

Nature

Steve Raoul Ngongang Noumegni , author
Jobert Richie Nansseu , author
Vicky Jocelyne Moor Ama , author
Jean Joel Bigna , author
Felix Kembe Assah , author
Magellan Guewo-Fokeng , author
Steve Leumi , author
Jean-Claude Katte , author
Mesmin Dehayem , author
Andre Pascal Kengne , author
Eugene Sobngwi , author

2017-01-01

Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. Results We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10–4.72). Conclusion Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.

Andre Pascal Kengne , author
Anushka Patel , author

2006-01-01

Kuguyo O , author
Kengne AP , author
Dandara C , author

2020-06-01

Omics : a journal of integrative biology

Mohsen Mazidi , author
Andre Pascal Kengne , author
Dimitri P. Mikhailidis , author
Arrigo F. Cicero , author
Maciej Banach , author

2017-01-01

Abstract ; Background and aim: Growing evidence suggests that some of the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed the relationship between selected dietary constituents and serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of United States adults. Methods: In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010. All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). Results: Of the 17,689 participants analysed, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample, 44.9 in men and 46.5 in women ( p = .047). The age-, race-, sex-, energy intake- and body mass index-adjusted mean dietary intakes of total dietary fibre, polyunsaturated fatty-acids, vitamin E, vitamin A, vitamin B6, total folate, vitamin B family, vitamin C, vitamin K, magnesium, iron, copper and potassium monotonically decreased across increasing hsCRP quarters ( p < .001 for all), whereas sugar intake increased ( p < .001). In analysis of covariance adjusted for potential confounders (age-, race-, sex-, energy intake- and body weight-) hsCRP levels increased across increasing quarters of sugar intake ( p < .001). Conclusions: This study provides further evidence of an association between dietary sugar, polyunsaturated fatty-acids, fibre and antioxidant intake and hsCRP levels, a subclinical inflammation marker. hsCRP concentrations are likely modulated by dietary intake.KEY MESSAGES Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake. Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables). hsCRP concentrations, and accordingly subclinical inflammation, are likely influenced by dietary intake.

Dzudie A , author
Rayner B , author
Ojji D , author
Schutte AE , author
Twagirumukiza M , author
Damasceno A , author
Ba SA , author
Kane A , author
Kramoh E , author
Anzouan Kacou JB , author
Onwubere B , author
Cornick R , author
Sliwa K , author
PASCAR Task Force on Hypertension , author

2017-10-01

Global heart

Balti EV , author
Kengne AP , author
Fokouo JVF , author
Nouthé BE , author
Sobngwi E , author

2013-12-01

PloS one

Chalmers J , author
Kengne AP , author
Joshi R , author
Perkovic V , author
Patel A , author

2007-06-01

Journal of hypertension. Supplement : official journal of the International Society of Hypertension

Kim Anh Nguyen , author
Naeemah Abrahams , author
Rachel Jewkes , author
Shibe Mhlongo , author
Soraya Seedat , author
Bronwyn Myers , author
Carl Lombard , author
Claudia Garcia-Moreno , author
Esnat Chirwa , author
Andre Pascal Kengne , author
Nasheeta Peer , author

2022-03-29

International Journal of Environmental Research and Public Health

Moloi MW , author
Kajawo S , author
Noubiap JJ , author
Mbah IO , author
Ekrikpo U , author
Kengne AP , author
Bello AK , author
Okpechi IG , author

2018-05-01

BMJ open

Lekoubou A , author
Philippeau F , author
Derex L , author
Olaru A , author
Gouttard M , author
Vieillart A , author
Kengne AP , author

2013-12-01

Neurological research

Matsha TE , author
Hassan MS , author
Hon GM , author
Soita DJ , author
Kengne AP , author
Erasmus RT , author

2013-05-01

International journal of cardiology

Matsha TE , author
Kengne AP , author
Masconi KL , author
Yako YY , author
Erasmus RT , author

2015-06-01

BMC genetics

Matsha TE , author
Yako YY , author
Rensburg MA , author
Hassan MS , author
Kengne AP , author
Erasmus RT , author

2013-04-01

BMC nephrology

Mazidi M , author
Shivappa N , author
Wirth MD , author
Hebert JR , author
Kengne AP , author

2018-11-01

European journal of clinical nutrition

Eric Walter Pefura-Yone , author
André Pascal Kengne , author
Emmanuel Afane-Ze , author
Christopher Kuaban , author

Background German cockroach or Blattella germanica is commonly found in homes across the inter-tropical region. The contribution of sensitisation to Blattella germanica in people with asthma in sub-Saharan Africa has not received attention. The aim of this study was to assess the prevalence and investigate the predicting factors of sensitisation to Blattella germanica in patients with asthma in Yaounde, Cameroon.Methods This was a cross-sectional study conducted between January 2012 and June 2013. All patients (aged 15 years and above) with asthma, receiving care at the Yaounde Jamot Hospital and the CEDIMER medical practice during the study period and who had received a prick skin testing for perennial aeroallergens were included in the study.Results The final sample comprised 184 patients including 123 (66.8%) women. The median age (25th-75th percentiles) was 38 (24–54) years. Prick skin test for Blattella germanica was positive in 47 (25.5%) patients. Sensitisation to Blattella germanica was associated with a sensitisation to mite in 41 (87.2%) patients, a sensitisation to Alternaria in 18 (38.3%) patients, and a sensitisation to cat or dog dander in 7 (14.9%) patients. Independent predicting factors of a sensitisation to Blattella germanica were the sensitisation to Blomia tropicalis [adjusted odd ratio (95% confidence interval) 4.10 (1.67-10.04), p = 0.002] and sensitisation to Alternaria [3.67 (1.53-7.46), p = 0.003].Conclusions Sensitisation to Blattella germanica is present in about a quarter of adult patients with asthma in Yaounde. Sensitisation to Alternaria and Blomia tropicalis appears to be a powerful predicting factor of sensitisation to Blattella germanica in this setting. Keywords: Asthma, Blattella, Allergy, Aeroallergens, Africa

Eric Walter Pefura-Yone , author
Emmanuel Soh , author
André Pascal Kengne , author
Adamou Dodo Balkissou , author
Christopher Kuaban , author

2013-01-01

Summary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31–0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14–2.28)], Pentecostal Christianity [2.18 (1.25–3.80)], alcohol consumption [1.65 (1.16–2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92–8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19–2.12)], [1.83 (1.36–2.47)], [1.70 (1.27–2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17–2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. Keywords: Antiretroviral therapy, Adherence, HIV infection, Cameroon

Riddell MA , author
Edwards N , author
Thompson SR , author
Bernabe-Ortiz A , author
Praveen D , author
Johnson C , author
Kengne AP , author
Liu P , author
McCready T , author
Ng E , author
Nieuwlaat R , author
Ovbiagele B , author
Owolabi M , author
GACD Hypertension Research Programme , author

2017-03-01

Globalization and health

GBD 2017 Gastro-oesophageal Reflux Disease Collaborators , author

2020-03-01

The lancet. Gastroenterology & hepatology

Igwesi-Chidobe CN , author
Godfrey EL , author
Kengne AP , author

2015-08-01

BMJ open

Ataklte F , author
Erqou S , author
Kaptoge S , author
Taye B , author
Echouffo-Tcheugui JB , author
Kengne AP , author

2014-11-01

Hypertension (Dallas, Tex. : 1979)

Wang H , author
Liddell CA , author
Coates MM , author
Mooney MD , author
Levitz CE , author
Schumacher AE , author
Apfel H , author
Iannarone M , author
Phillips B , author
Lofgren KT , author
Sandar L , author
Dorrington RE , author
Rakovac I , author
Murray CJ , author

2014-05-01

Lancet (London, England)

Odukoya OO , author
Ohazurike C , author
Akanbi M , author
O'Dwyer LC , author
Isikekpei B , author
Kuteyi E , author
Ameh IO , author
Osadiaye O , author
Adebayo K , author
Usinoma A , author
Adewole A , author
Odunukwe N , author
Okuyemi K , author
Kengne AP , author

2021-06-01

JMIR mHealth and uHealth

Kaze FF , author
Kengne AP , author
Atanga LC , author
Monny Lobe M , author
Menanga AP , author
Halle MP , author
Chetcha Chemegni B , author
Ngo Sack F , author
Kingue S , author
Ashuntantang G , author

2012-10-01

Clinical kidney journal

GBD 2020 , author
Release 1 , author
Vaccine Coverage Collaborators , author

2021-07-01

Lancet (London, England)

Fezeu LK , author
Assah FK , author
Balkau B , author
Mbanya DS , author
Kengne AP , author
Awah PK , author
Mbanya JC , author

2008-03-01

Obesity (Silver Spring, Md.)

Kengne AP , author
Dzudie AI , author
Fezeu LL , author
Mbanya JC , author

2006-03-01

The international journal of lower extremity wounds

Kengne AP , author
Awah PK , author
Fezeu L , author
Mbanya JC , author

2007-03-01

African health sciences

Vergotine Z , author
Kengne AP , author
Erasmus RT , author
Yako YY , author
Matsha TE , author

2014-08-01

International journal of endocrinology

Aminde LN , author
Takah NF , author
Noubiap JJ , author
Tindong M , author
Ngwasiri C , author
Jingi AM , author
Kengne AP , author
Dzudie A , author

2015-11-01

BMC public health

Moons KG , author
Kengne AP , author
Woodward M , author
Royston P , author
Vergouwe Y , author
Altman DG , author
Grobbee DE , author

2012-03-01

Heart (British Cardiac Society)

van Dieren S , author
Kengne AP , author
Chalmers J , author
Beulens JW , author
Cooper ME , author
Grobbee DE , author
Harrap S , author
Mancia G , author
Neal B , author
Patel A , author
Poulter N , author
van der Schouw YT , author
Woodward M , author
Zoungas S , author

2012-06-01

Diabetes research and clinical practice

GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators , author

2018-11-01

The Lancet. Neurology

Eric Vounsia Balti , author
André Pascal Kengne , author
Jean Valentin Fogha Fokouo , author
Brice Enid Nouthé , author
Eugene Sobngwi , author

BACKGROUND AND PURPOSE: Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa). METHODS: Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment. RESULTS: Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p≤0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p = 0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p = 0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset. CONCLUSION: The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.

Carmen Pheiffer , author
Victoria Pillay-van Wyk , author
Eunice Turawa , author
Naomi Levitt , author
Andre P. Kengne , author
Debbie Bradshaw , author

2021-05-30

International Journal of Environmental Research and Public Health

Di Cesare M , author
Sorić M , author
Bovet P , author
Miranda JJ , author
Bhutta Z , author
Stevens GA , author
Laxmaiah A , author
Kengne AP , author
Bentham J , author

2019-11-01

BMC medicine

Muyunda Mutemwa , author
Nasheeta Peer , author
Anniza De Villiers , author
Mieke Faber , author
Andre-Pascal Kengne , author

2020-04-21

Southern African Journal of HIV Medicine

Peer N , author
Naicker A , author
Khan M , author
Kengne AP , author

2020-07-01

SAGE open medicine

Anastase, Dzudie , author
Suiru, Dzekem , author
Andre, Pascal Kengne , author

2017-01-01

Macharia M , author
Kengne AP , author
Blackhurst DM , author
Erasmus RT , author
Matsha TE , author

2013-07-01

Journal of clinical pathology

NCD Risk Factor Collaboration (NCD-RisC) , author

2020-06-01

Nature

Kuate-Tegueu C , author
Temfack E , author
Ngankou S , author
Doumbe J , author
Djientcheu VP , author
Kengne AP , author

2015-05-01

Journal of the neurological sciences

Davidson FE , author
Matsha TE , author
Erasmus RT , author
Ismail S , author
Kengne AP , author
Goedecke JH , author

2020-04-01

European journal of clinical nutrition

NCD Risk Factor Collaboration (NCD-RisC) , author

2021-08-01

Lancet (London, England)

Davids SF , author
Matsha TE , author
Peer N , author
Erasmus RT , author
Kengne AP , author

2019-11-01

Frontiers in endocrinology

Aminde LN , author
Dzudie A , author
Kengne AP , author

2016-02-01

BMJ open

Kuate D , author
Kengne AP , author
Biapa CP , author
Azantsa BG , author
Abdul Manan Bin Wan Muda W , author

2015-05-01

Lipids in health and disease

Kengne AP , author
Czernichow S , author
Huxley R , author
Grobbee D , author
Woodward M , author
Neal B , author
Zoungas S , author
Cooper M , author
Glasziou P , author
Hamet P , author
Harrap SB , author
Mancia G , author
Poulter N , author
ADVANCE Collaborative Group , author

2009-05-01

Hypertension (Dallas, Tex. : 1979)

Davidson FE , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author
Goedecke JH , author

2019-11-01

Diabetology & metabolic syndrome

Peprah E , author
Armstrong-Hough M , author
Cook S , author
Mukasa B , author
Taylor J , author
Xu H , author
Chang L , author
Gyamfi J , author
Ryan N , author
Ojo T , author
Snyder A , author
Iwelunmor J , author
Ezechi O , author
Iyegbe C , author
Pascal Kengne A , author

2021-03-01

International journal of environmental research and public health

Kengne AP , author
Dzudie A , author
Sobngwi E , author

2008-01-01

Vascular health and risk management

Yone EW , author
Balkissou AD , author
Kengne AP , author
Kuaban C , author

2012-08-01

BMC pulmonary medicine

Adom T , author
Puoane T , author
De Villiers A , author
Kengne AP , author

2017-02-01

BMJ open

Gary Maartens , author
Annemie Stewart , author
Rulan Griesel , author
Andre P. Kengne , author
Felix Dube , author
Mark Nicol , author
Molebogeng X. Rangaka , author
Marc Mendelson , author

2018-07-23

Southern African Journal of HIV Medicine

Masoud M , author
Kengne AP , author
Erasmus RT , author
Hon GM , author
Macharia M , author
Matsha TE , author

2018-03-01

Indian journal of clinical biochemistry : IJCB

Dzudie A , author
Choukem SP , author
Dehayem MY , author
Kengne AP , author

2012-12-01

Journal of diabetes

Thomas B , author
Matsushita K , author
Abate KH , author
Al-Aly Z , author
Ärnlöv J , author
Asayama K , author
Atkins R , author
Badawi A , author
Ballew SH , author
Banerjee A , author
Barregård L , author
Barrett-Connor E , author
Basu S , author
Global Burden of Disease Genitourinary Expert Group , author

2017-04-01

Journal of the American Society of Nephrology : JASN

Kengne AP , author
Awah PK , author

2009-01-01

QJM : monthly journal of the Association of Physicians

Jillian Hill , author
Camille Lavigne Delville , author
Anne-Marie Auorousseau , author
Deborah Jonathan , author
Nasheeta Peer , author
Brian Oldenburg , author
Andre-Pascal Kengne , author

2020-01-30

International Journal of Environmental Research and Public Health

Mhandire D , author
Mhandire K , author
Magadze M , author
Wonkam A , author
Kengne AP , author
Dandara C , author

2020-05-01

GBD 2016 Risk Factors Collaborators , author

2017-09-01

Lancet (London, England)

Malambo P , author
Kengne AP , author
Lambert EV , author
De Villiers A , author
Puoane T , author

2017-10-01

Journal of physical activity & health

Kaze FF , author
Kengne AP , author
Magatsing CT , author
Halle MP , author
Yiagnigni E , author
Ngu KB , author

2016-01-01

Journal of clinical hypertension (Greenwich, Conn.)

Kaze FF , author
Kengne AP , author
Choukem SP , author
Dzudie A , author
Halle MP , author
Dehayem MY , author
Ashuntantang G , author

2008-06-01

American journal of kidney diseases : the official journal of the National Kidney Foundation

Mazidi M , author
Ofori-Asenso R , author
Kengne AP , author

2020-05-01

Journal of gastroenterology and hepatology

Nkoke C , author
Balti E , author
Menanga A , author
Dzudie A , author
Lekoubou A , author
Kingue S , author
Kengne AP , author

2017-01-01

Translational pediatrics

ADVANCE Collaborative Group , author
Patel A , author
MacMahon S , author
Chalmers J , author
Neal B , author
Billot L , author
Woodward M , author
Marre M , author
Cooper M , author
Glasziou P , author
Grobbee D , author
Hamet P , author
Travert F , author

2008-06-01

The New England journal of medicine

Ngwa EN , author
Kengne AP , author
Tiedeu-Atogho B , author
Mofo-Mato EP , author
Sobngwi E , author

2015-04-01

Diabetology & metabolic syndrome

George C , author
Matsha TE , author
Korf M , author
Zemlin AE , author
Erasmus RT , author
Kengne AP , author

2020-01-01

BMC nephrology

Lekoubou A , author
Clovis N , author
Dzudie A , author
Kengne AP , author

2016-07-01

Primary care diabetes

Olalekan A Uthman , author
Chidozie U Nduka , author
Mustapha Abba , author
Rocio Enriquez , author
Helena Nordenstedt , author
Fred Nalugoda , author
Andre P Kengne , author
Anna M Ekström , author

2017-11-16

Andre Pascal Kengne , author
Sébastien Czernichow , author
Mark Hamer , author
G David Batty , author
Emmanuel Stamatakis , author

Both anaemia and cardiovascular disease (CVD) are common in people with diabetes. While individually both characteristics are known to raise mortality risk, their combined influence has yet to be quantified. In this pooling project, we examined the combined impact of baseline haemoglobin levels and existing CVD on all-cause and CVD mortality in people with diabetes. We draw comparison of these effects with those apparent in diabetes-free individuals.A combined analyses of 7 UK population-based cohorts resulted in 26,480 study members. There were 946 participants with physician-diagnosed diabetes, 2227 with anaemia [haemoglobin<13 g/dl (men) or <12 (women)], 2592 with existing CVD (stroke, ischaemic heart disease), and 21,396 with none of the conditions. Across diabetes and anaemia subgroups, and using diabetes-free, non-anaemic participants as the referent group, the adjusted hazard ratios (HR) were 1.46 (95% CI: 1.30-1.63) for anaemia, 1.67 (1.45-1.92) for diabetes, and 2.10 (1.55-2.85) for diabetes and anaemia combined. Across combined diabetes, anaemia and CVD subgroups, and compared with non-anaemic, diabetes-free and CVD-free participants, HR (95% CI) for all-cause mortality were 1.49 (1.32-1.69) anaemia, 1.60 (1.46-1.76) for existing CVD, and 1.66 (1.39-1.97) for diabetes alone. Equivalents were 2.13 (1.48-3.07) for anaemia and diabetes, 2.68 (2.14-3.36) for diabetes and existing CVD, and 3.25 (1.88-5.62) for the three combined. Patterns were similar for CVD mortality.Individually, anaemia and CVD confer similar mortality risks in people with diabetes, and are excessively fatal in combination. Screening for anaemia would identify vulnerable diabetic patients whose outcomes can potentially be improved.

Mazidi M , author
Kengne AP , author

2018-08-01

Clinical nutrition (Edinburgh, Scotland)

Cecil J. Weale , author
Glenda M. Davison , author
Gloudina M. Hon , author
Andre P. Kengne , author
Rajiv T. Erasmus , author
Tandi E. Matsha , author

2019-05-16

Cells

Eric Walter , author
Pefura Yone , author
Awa Foueudjeu Betyoumin , author
André Pascal Kengne , author
François Jérome , author
Kaze Folefack , author
Jeanne Ngogang , author

First-line antiretroviral therapy and dyslipidemia in people living with HIV-1 in Cameroon: a cross-sectional study

Dzudie A , author
Aminde L , author
Ngowe Ngowe M , author
Takah N , author
Luma HN , author
Doualla MS , author
Mapoure Y , author
Mbatchou H , author
Njamen TN , author
Priso EB , author
Kengne AP , author
Sliwa-Hahnle K , author
Nkwescheu AS , author
Sone AM , author

2014-09-01

Cardiovascular journal of Africa

Mazidi M , author
Kengne AP , author

2017-03-01

European journal of clinical investigation

Kaze AD , author
Schutte AE , author
Erqou S , author
Kengne AP , author
Echouffo-Tcheugui JB , author

2017-07-01

Journal of hypertension

Echouffo-Tcheugui JB , author
Sobngwi E , author
Kengne AP , author

2012-03-01

Archives of internal medicine

NCD Countdown 2030 collaborators , author

2018-09-01

Lancet (London, England)

Choukem SP , author
Sih C , author
Ntumsi AT , author
Dimala CA , author
Mboue-Djieka Y , author
Ngouadjeu EDT , author
Kengne AP , author

2020-03-01

BMC cardiovascular disorders

Kaze FF , author
Njukeng FA , author
Kengne AP , author
Ashuntantang G , author
Mbu R , author
Halle MP , author
Asonganyi T , author

2014-04-01

BMC pregnancy and childbirth

Steve Raoul Noumegni , author
Jobert Richie Nansseu , author
Jean Joel Bigna , author
Vicky Jocelyne Ama Moor , author
Felix Kembe Assah , author
Mesmin Y Dehayem , author
Andre Pascal Kengne , author
Eugene Sobngwi , author

2017-01-01

Background The paucity of data regarding the association between atherogenic index of plasma and risk of cardiovascular disease in HIV-infected populations living in sub-Saharan Africa prompted us to conduct this study which aimed to assess the relationship between atherogenic index of plasma and risk of cardiovascular disease among a Cameroonian HIV-infected population. Methods This was a cross-sectional study conducted among 452 HIV-infected adults in Yaoundé, Cameroon. Risk of cardiovascular disease was calculated using the Framingham risk score; atherogenic index of plasma was derived as log (triglycerides/high-density lipoproteins cholesterol). Results Participants’ mean age (80% females) was 44.4 ± 9.8 years. Atherogenic index of plasma values ranged from –0.63 to 1.36 with a median of 0.11 (25th–75th percentiles: –0.08-0.31). Most participants (88.5%) were on antiretroviral treatment. There was a significant correlation between atherogenic index of plasma and fasting plasma glucose (r = 0.116; p = 0.014), atherogenic index of plasma and total cholesterol (r = –0.164; p < 0.001). Atherogenic index of plasma was significantly associated with the risk of cardiovascular disease either in univariable (β = 5.05, 95% CI: 3.31–6.79; p < 0.001, R 2 = 0.067) or in multivariable linear regression model after adjusting for socio-demographic, clinical and biological confounders (adjusted β = 3.79, 95% CI: 1.65 – 4.88; p < 0.001, R 2 = 0.187). Conclusion Atherogenic index of plasma may be an independent factor impacting the risk of cardiovascular disease among Cameroonian HIV-infected people. More studies are needed to better elucidate the association between atherogenic index of plasma and risk of cardiovascular disease in our setting.

GBD 2013 Mortality and Causes of Death Collaborators , author

2014-12-01

Lancet (London, England)

Moons KG , author
Kengne AP , author
Grobbee DE , author
Royston P , author
Vergouwe Y , author
Altman DG , author
Woodward M , author

2012-03-01

Heart (British Cardiac Society)

Andre Pascal Kengne , author
Anastase Dzudie , author
Eugene Sobngwi , author

2008-01-01

Andre Pascal Kengne1, Anastase Dzudie2, Eugene Sobngwi31The George Institute for International Health, University of Sydney, Australia; 2Heart failure and transplantation Unit, Louis Pradel’s Cardiovascular Hospital, Lyon, France; 3National Obesity Centre, Yaounde Central Hospital, CameroonPurpose: Heart failure is the ultimate complication of cardiac involvements in diabetes. The purpose of this review was to summarize current literature on heart failure among people with diabetes mellitus in sub-Saharan Africa (SSA).Method: Bibliographic search of published data on heart failure and diabetes in sub-Saharan Africa over the past 26 years.Results: Heart failure remains largely unexplored in general population and among people with diabetes in Africa. Heart failure accounts for over 30% of hospital admission in specialized cardiovascular units and 3%–7% in general internal medicine. Over 11% of adults with heart failure have diabetes. Risk factors for heart failure among those with diabetes include classical cardiovascular risk factors, without evidence of diabetes distinctiveness for other predictors common in Africa. Prevention, management, and outcomes of heart failure are less well known; recent data suggest improvement in the management of risk factors in clinical settings.Conclusions: Diabetes mellitus is growing in SSA. Related cardiovascular diseases are emerging as potential health problem. Heart failure as cardiovascular complication remains largely unexplored. Efforts are needed through research to improve our knowledge of heart failure at large in Africa. Multilevel preventive measures, building on evidences from other parts of the world must go along side.Keywords: diabetes mellitus, cardiovascular diseases, heart failure, sub-Saharan Africa

Alain Lekoubou , author
Paschal Awah , author
Leopold Fezeu , author
Eugene Sobngwi , author
Andre Pascal Kengne , author

2010-01-01

Chronic diseases are becoming increasingly important in sub-Saharan Africa (SSA). The current density and distribution of health workforce suggest that SSA cannot respond to the growing demand for chronic disease care, together with the frequent infectious diseases. Innovative approaches are therefore needed to rapidly expand the health workforce. In this article, we discuss the evidences in support of nurse-led strategies for chronic disease management in SSA, with a focus on hypertension and diabetes mellitus.

Kengne AP , author
Masconi K , author
Mbanya VN , author
Lekoubou A , author
Echouffo-Tcheugui JB , author
Matsha TE , author

2013-12-01

Critical reviews in clinical laboratory sciences

Yone EW , author
Kengne AP , author

2012-12-01

HIV/AIDS (Auckland, N.Z.)

Ruffieux N , author
Njamnshi AK , author
Mayer E , author
Sztajzel R , author
Eta SC , author
Doh RF , author
Kengne AM , author
Ngamaleu RN , author
Chanal J , author
Verdon V , author
Hauert CA , author

2009-04-01

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

George C , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author

2018-11-01

BMJ open

Camara A , author
Baldé NM , author
Sobngwi-Tambekou J , author
Kengne AP , author
Diallo MM , author
Tchatchoua AP , author
Kaké A , author
Sylvie N , author
Balkau B , author
Bonnet F , author
Sobngwi E , author

2014-09-01

Diabetes research and clinical practice

Mazidi M , author
Kengne AP , author
Katsiki N , author
Mikhailidis DP , author
Banach M , author

2017-10-01

Journal of diabetes and its complications

Lekoubou Looti AZ , author
Kengne AP , author
Djientcheu Vde P , author
Kuate CT , author
Njamnshi AK , author

2010-07-01

Journal of neurology, neurosurgery, and psychiatry

Peer N , author
George C , author
Kengne AP , author

2019-12-01

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Clement N. Kufe , author
Lisa K. Micklesfield , author
Maphoko Masemola , author
Tinashe Chikowore , author
Andre Pascal Kengne , author
Fredrik Karpe , author
Shane A. Norris , author
Nigel J. Crowther , author
Tommy Olsson , author
Julia H. Goedecke , author

2021-10-26

GBD 2015 Mortality and Causes of Death Collaborators , author

2016-10-01

Lancet (London, England)

Theodosia Adom , author
Anniza De Villiers , author
Thandi Puoane , author
André Pascal Kengne , author

2021-11-11

Nutrients

Duan D , author
Kengne AP , author
Echouffo-Tcheugui JB , author

2021-07-01

Endocrinology and metabolism clinics of North America

Mutemwa M , author
Peer N , author
de Villiers A , author
Mukasa B , author
Matsha TE , author
Mills EJ , author
Kengne AP , author

2018-08-01

Medicine

Choukem SP , author
Dzudie A , author
Dehayem M , author
Halle MP , author
Doualla MS , author
Luma H , author
Kengne AP , author

2012-04-01

The Pan African medical journal

Nguyen KA , author
Peer N , author
Mills EJ , author
Kengne AP , author

2016-03-01

PloS one

Mohsen Mazidi , author
Andre Pascal Kengne , author
L. J. Cheskin , author
Maciej Banach , author

2018-01-01

Abstract Background To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults. Methods Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights. Results Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-β-carotene, cis- β-carotene, β-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001). Conclusions Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.

Mazidi M , author
Shivappa N , author
Wirth MD , author
Hebert JR , author
Vatanparast H , author
Kengne AP , author

2017-10-01

European journal of clinical nutrition

Pefura-Yone EW , author
Mbele-Onana CL , author
Balkissou AD , author
Kenmegne-Noumsi EC , author
Boulleys-Nana JR , author
Kolontchang-Yomi BL , author
Theubo-Kamgang BJ , author
Ndjeutcheu-Moualeu PI , author
for Groupe Enquête en Santé Respiratoire au Cameroun (GESRC) , author

2015-07-01

The Journal of asthma : official journal of the Association for the Care of Asthma

Kassebaum NJ , author
Bertozzi-Villa A , author
Coggeshall MS , author
Shackelford KA , author
Steiner C , author
Heuton KR , author
Gonzalez-Medina D , author
Barber R , author
Huynh C , author
Dicker D , author
Templin T , author
Lozano R , author

2014-05-01

Lancet (London, England)

Ibrahim Chikowe , author
Victor Mwapasa , author
Andre Pascal Kengne , author

2018-01-01

Abstract Objective There is limited data on the quality of primary care management for diabetes mellitus across Africa. The study was aimed at assessing the availability of basic supplies for the rapid diagnosis, treatment and management of diabetes in Malawian rural health facilities. This cross-sectional study was conducted in 55 public and private health centers from 19 districts using a structured questionnaire and checklist to interview the pharmacy personnel or officer in-charge of the health centers. We focused on availability of information, diagnosis and treatment materials for diabetes. Results Of the 55 health facilities surveyed, 21, 23 and 11 were located in the central, southern and northern regions of Malawi, respectively. Overall, 38% (21/55) of the health centres had glucometers, while 24% (13/55) had urine glucose dipsticks. Only 4% (2/55) of the health centres had recommended first-line medicines for treatment of type 1 and type 2 diabetes. No health centre had diabetes patient records and information, education and communication materials. Most rural health centers in Malawi lack basic health commodities for the screening, diagnosis and treatment of diabetes and this impedes on their effective management of growing diabetes burden. Therefore, health care systems need to adequately equip primary care facilities.

Kaze FF , author
Halle MP , author
Mopa HT , author
Ashuntantang G , author
Fouda H , author
Ngogang J , author
Kengne AP , author

2015-07-01

BMC nephrology

Pefura-Yone EW , author
Kengne AP , author
Balkissou AD , author
Magne-Fotso CG , author
Ngo-Yonga M , author
Boulleys-Nana JR , author
Efe-de-Melingui NR , author
Ndjeutcheu-Moualeu PI , author
Mbele-Onana CL , author
Respiratory Health Survey Group in Cameroon (RHSGC) , author

2016-02-01

BMC research notes

Noumegni SR , author
Ama VJM , author
Assah FK , author
Bigna JJ , author
Nansseu JR , author
Kameni JAM , author
Katte JC , author
Dehayem MY , author
Kengne AP , author
Sobngwi E , author

2017-07-01

Tropical diseases, travel medicine and vaccines

Gouda HN , author
Charlson F , author
Sorsdahl K , author
Ahmadzada S , author
Ferrari AJ , author
Erskine H , author
Leung J , author
Santamauro D , author
Lund C , author
Aminde LN , author
Mayosi BM , author
Kengne AP , author
Harris M , author
Whiteford H , author

2019-10-01

The Lancet. Global health

Kengne AP , author
Ntsekhe M , author

2018-05-01

Circulation

Masconi KL , author
Echouffo-Tcheugui JB , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author

2015-02-01

Expert review of endocrinology & metabolism

GBD 2016 DALYs and HALE Collaborators , author

2017-09-01

Lancet (London, England)

Goedecke JH , author
Mtintsilana A , author
Dlamini SN , author
Kengne AP , author

2016-12-01

Diabetes research and clinical practice

Kengne AP , author
Limen SN , author
Sobngwi E , author
Djouogo CF , author
Nouedoui C , author

2012-05-01

Diabetology & metabolic syndrome

Kaze FF , author
Maimouna M , author
Beybey AF , author
Pefura-Yone EW , author
Balkissou AD , author
Halle MP , author
Kowo MP , author
Ashuntantang G , author
Kengne AP , author

2021-03-01

Clinical and experimental nephrology

Peer N , author
Kengne AP , author
Motala AA , author
Mbanya JC , author

2013-12-01

Diabetes research and clinical practice

Kengne AP , author
Sobngwi E , author
Fezeu LL , author
Awah PK , author
Dongmo S , author
Mbanya JC , author

2008-08-01

The Journal of asthma : official journal of the Association for the Care of Asthma

Jun Hata , author
Hisatomi Arima , author
Sophia Zoungas , author
Greg Fulcher , author
Carol Pollock , author
Mark Adams , author
John Watson , author
Rohina Joshi , author
Andre Pascal Kengne , author
Toshiharu Ninomiya , author
Craig Anderson , author
Mark Woodward , author
Anushka Patel , author
Giuseppe Mancia , author
Neil Poulter , author
Stephen MacMahon , author
John Chalmers , author
Bruce Neal , author

Endpoint adjudication committees (EPAC) are widely used in clinical trials. The aim of the present analysis is to assess the effects of the endpoint adjudication process on the main findings of the ADVANCE trial (Trial registration: ClinicalTrials.gov NCT00145925).The ADVANCE trial was a multicentre, 2 × 2 factorial randomised controlled trial of blood pressure lowering and intensive blood glucose control in 11140 patients with type 2 diabetes. Primary outcomes were major macrovascular (nonfatal myocardial infarction, nonfatal stroke and cardiovascular death) and microvascular (new or worsening nephropathy and retinopathy) events. Suspected primary outcomes were initially reported by the investigators at the 215 sites with subsequent adjudication by the EPAC. The EPAC also adjudicated upon potential events identified directly by ongoing screening of all reported events. Over a median follow-up of 5 years, the site investigators reported one or more primary outcomes among 2443 participants. After adjudication these events were confirmed for 2077 (85%) with 48 further events added through the EPAC-led database screening process. The estimated relative risk reductions (95% confidence intervals) in the primary outcome for the blood pressure lowering comparison were 8% (-1 to 15%) based on the investigator-reported events and 9% (0 to 17%) based on the EPAC-based events (P for homogeneity = 0.70). The corresponding findings for the glucose comparison were 8% (1 to 15%) and 10% (2% to 18%) (P for homogeneity = 0.60). The effect estimates were also highly comparable when studied separately for macrovascular events and microvascular events for both comparisons (all P for homogeneity>0.6).The endpoint adjudication process had no discernible impact on the main findings in ADVANCE. These data highlight the need for careful consideration of the likely impact of an EPAC on the findings and conclusions of clinical trials prior to their establishment.

Dzudie A , author
Njume E , author
Mfekeu LK , author
Djomou A , author
Ba H , author
Ndom MS , author
Nkoke C , author
Ndongo S , author
Boombhi J , author
Kamdem F , author
Mouandjo JPD , author
Mouliom SA , author
Kouam CK , author
Meli H , author
Monkam Y , author
Cameroon Cardiac Society and MMM Cameroon investigator group , author

2021-05-01

European heart journal supplements : journal of the European Society of Cardiology

2005-12-01

Circulation

BACKGROUND: Cardiovascular disease, the major cause of mortality and morbidity in modern societies, is set to overtake infectious diseases in the developing world as the most common cause of death. The increasing prevalence of major and emerging cardiovascular risk factors accounts for the growing burden of cardiovascular disease in the world. Diabetes in all its forms is one of the main cardiovascular risk factors. Two of 3 diabetic patients will die as a result of cardiovascular complications, and approximately 30% of patients treated in cardiovascular intensive care units have diabetes. METHODS AND RESULTS: This review on the cardiovascular complications of diabetes in sub-Saharan Africa is a bibliographical MEDLINE search of published data over the past 2 decades. Diabetes-related cardiovascular disease complications are considered to be rare in Africa but are on the rise and are regularly associated with classic cardiovascular risk factors. Coronary heart disease may affect 5% to 8% of type 2 diabetic patients and cardiomyopathy, up to 50% of all patients. Close to 15% of patients with stroke have diabetes, and up to 5% of diabetic patients present with cerebrovascular accidents at diagnosis. Peripheral vascular disease prevalence varies across sites from 4% to 28%. CONCLUSIONS: It is obvious that diabetes mellitus and related cardiovascular complications are gaining more importance in sub-Saharan Africa. The relative contribution of putative risk factors is not well defined, and further research is therefore needed.

Halle MP , author
Zebaze PN , author
Mbofung CM , author
Kaze F , author
Mbiatat H , author
Ashuntantang G , author
Kengne AP , author

2014-01-01

Journal of nephrology

Echouffo-Tcheugui JB , author
Kengne AP , author

2013-09-01

Diabetes & metabolism

Mohsen Mazidi , author
Hong-kai Gao , author
Andre Pascal Kengne , author

2017-01-01

Journal of Nutrition and Metabolism

Tandi E. Matsha , author
Saaiga Ismail , author
Aladdin Speelman , author
Gloudina M. Hon , author
Saarah Davids , author
Rajiv T. Erasmus , author
Andre P. Kengne , author

2019-08-01

Clinical Nutrition ESPEN

Noubiap JJ , author
Nansseu JR , author
Bigna JJ , author
Jingi AM , author
Kengne AP , author

2015-03-01

BMJ open

Noubiap JJ , author
Agbaedeng TA , author
Ndoadoumgue AL , author
Nyaga UF , author
Kengne AP , author

2021-05-01

Journal of cardiovascular electrophysiology

GBD 2015 Child Mortality Collaborators , author

2016-10-01

Lancet (London, England)

Eric Walter Pefura-Yone , author
Adamou Dodo Balkissou , author
Virginie Poka-Mayap , author
Hadja Koté Fatime-Abaicho , author
Patrick Thierry Enono-Edende , author
André Pascal Kengne , author

2017-01-01

Abstract Background Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas. Methods We used data for patients aged ≥15 years, diagnosed and treated for tuberculosis at the Yaounde Jamot Hospital between January 2012 and December 2013. Baseline characteristics associated with mortality were investigated using logistic regressions. A simple prognosis score (CABI) was constructed with regression coefficients for predictors in the final model. Internal validation used bootstrap resampling procedures. Models discrimination was assessed using c-statistics and calibration assessed via calibration plots and the Hosmer and Lemeshwow (H-L) statistics. The optimal score was based on the Youden’s index. Results A total of 2250 patients (men 57.2%) with a mean age of 35.8 years were included; among whom 213 deaths (cumulative incidence 9.5%) were recorded. Clinical form of tuberculosis (C), age (A, years), adjusted body mass index (B, BMI, kg/m2) and status for HIV (Human immunodefiency virus) infection (I) were significant predictors in the final model (p < 0.0001) which was of the form Death risk = 1/(1 + e − (−1.3120 + 0.0474 ∗ age − 0.1866 ∗ BMI + 1.1637 (if smear negative TB) + 0.5418(if extra − pulmonary TB) + 1.3820(if HIV+))). The c-statistic was 0.812 in the derivation sample and 0.808 after correction for optimism. The calibration was good [H-Lχ2 = 6.44 (p = 0.60)]. The optimal absolute risk threshold was 4.8%, corresponding to a sensitivity of 81% and specificity of 67%. Conclusions The preliminary promising findings from this study require confirmation through independent external validation studies. If confirmed, the model derived could facilitate the stratification of TB patients for mortality risk and implementation of additional monitoring and management measures in vulnerable patients.

Khazdouz M , author
Mazidi M , author
Ehsaei MR , author
Ferns G , author
Kengne AP , author
Norouzy AR , author

2017-05-01

Journal of dietary supplements

Arthemon Nguweneza , author
Chandré Oosterwyk , author
Kambe Banda , author
Victoria Nembaware , author
Gaston Mazandu , author
Andre P Kengne , author
Ambroise Wonkam , author

2022-04-03

Expert Review of Hematology

Nguyen KA , author
Peer N , author
de Villiers A , author
Mukasa B , author
Matsha TE , author
Mills EJ , author
Kengne AP , author

2017-09-01

PloS one

Theodosia Adom , author
André Pascal Kengne , author
Anniza De Villiers , author
Rose Boatin , author
Thandi Puoane , author

2019-12-19

International Journal of Environmental Research and Public Health

Kengne AP , author
Czernichow S , author
Stamatakis E , author
Hamer M , author
Batty GD , author

2012-07-01

Diabetes & vascular disease research

Zemlin AE , author
Matsha TE , author
Kengne AP , author
Hon G , author
Erasmus RT , author

2016-10-01

Journal of medical biochemistry

George C , author
Goedecke JH , author
Crowther NJ , author
Jaff NG , author
Kengne AP , author
Norris SA , author
Micklesfield LK , author

2016-05-01

PloS one

Businge CB , author
Madini N , author
Longo-Mbenza B , author
Kengne AP , author

2019-05-01

BMJ open

Global Burden of Disease Study 2013 Collaborators , author

2015-06-01

Lancet (London, England)

Kanmogne GD , author
Fonsah JY , author
Umlauf A , author
Moul J , author
Doh RF , author
Kengne AM , author
Tang B , author
Tagny CT , author
Nchindap E , author
Kenmogne L , author
Franklin D , author
Njamnshi DM , author
Kuate CT , author
Mbanya D , author
Heaton RK , author

2020-08-01

Scientific reports

Gertrude Nsorma Nyaaba , author
Karien Stronks , author
Ama de-Graft Aikins , author
Andre Pascal Kengne , author
Charles Agyemang , author

2017-01-01

Abstract Background Half of the estimated annual 28 million non-communicable diseases (NCDs) deaths in low- and middle-income countries (LMICs) are attributed to weak health systems. Current health policy responses to NCDs are fragmented and vertical particularly in the African region. The World Health Organization (WHO) led NCDs Global action plan 2013–2020 has been recommended for reducing the NCD burden but it is unclear whether Africa is on track in its implementation. This paper synthesizes Africa’s progress towards WHO policy recommendations for reducing the NCD burden. Methods Data from the WHO 2011, 2014 and 2015 NCD reports were used for this analysis. We synthesized results by targets descriptions in the three reports and included indicators for which we could trace progress in at least two of the three reports. Results More than half of the African countries did not achieve the set targets for 2015 and slow progress had been made towards the 2016 targets as of December 2013. Some gains were made in implementing national public awareness programmes on diet and/or physical activity, however limited progress was made on guidelines for management of NCD and drug therapy and counselling. While all regions in Africa show waning trends in fully achieving the NCD indicators in general, the Southern African region appears to have made the least progress while the Northern African region appears to be the most progressive. Conclusion Our findings suggest that Africa is off track in achieving the NCDs indicators by the set deadlines. To make sustained public health gains, more effort and commitment is urgently needed from governments, partners and societies to implement these recommendations in a broader strategy. While donors need to suit NCD advocacy with funding, African institutions such as The African Union (AU) and other sub-regional bodies such as West African Health Organization (WAHO) and various country offices could potentially play stronger roles in advocating for more NCD policy efforts in Africa.

Kajawo S , author
Moloi MW , author
Noubiap JJ , author
Ekrikpo U , author
Kengne AP , author
Okpechi IG , author

2018-04-01

BMJ open

Kanmogne GD , author
Fonsah JY , author
Tang B , author
Doh RF , author
Kengne AM , author
Umlauf A , author
Tagny CT , author
Nchindap E , author
Kenmogne L , author
Franklin D , author
Njamnshi DM , author
Mbanya D , author
Njamnshi AK , author
Heaton RK , author

2018-12-01

Scientific reports

Kajawo S , author
Ekrikpo U , author
Moloi MW , author
Noubiap JJ , author
Osman MA , author
Okpechi-Samuel US , author
Kengne AP , author
Bello AK , author
Okpechi IG , author

2020-11-01

Kidney international reports

Andre Pascal Kengne , author
Anastase Dzudie , author
Eugene Sobngwi , author
Correspondence Andre , author
Pascal Kengne , author

Purpose: Heart failure is the ultimate complication of cardiac involvements in diabetes. The purpose of this review was to summarize current literature on heart failure among people with diabetes mellitus in sub-Saharan Africa (SSA). Method: Bibliographic search of published data on heart failure and diabetes in sub-Saharan Africa over the past 26 years. Results: Heart failure remains largely unexplored in general population and among people with diabetes in Africa. Heart failure accounts for over 30 % of hospital admission in specialized cardiovascular units and 3%–7 % in general internal medicine. Over 11 % of adults with heart failure have diabetes. Risk factors for heart failure among those with diabetes include classical cardiovascular risk factors, without evidence of diabetes distinctiveness for other predictors common in Africa. Prevention, management, and outcomes of heart failure are less well known; recent data suggest improvement in the management of risk factors in clinical settings. Conclusions: Diabetes mellitus is growing in SSA. Related cardiovascular diseases are emerging as potential health problem. Heart failure as cardiovascular complication remains largely unexplored. Efforts are needed through research to improve our knowledge of heart failure at large in Africa. Multilevel preventive measures, building on evidences from other parts of the world must go along side.

Oluwatoyin I. Ameh , author
Udeme E. Ekrikpo , author
Andre-Pascal Kengne , author

2020-03-01

Kidney International Reports

Tesema AG , author
Ajisegiri WS , author
Abimbola S , author
Balane C , author
Kengne AP , author
Shiferaw F , author
Dangou JM , author
Narasimhan P , author
Joshi R , author
Peiris D , author

2020-10-01

PloS one

Caleyachetty R , author
Echouffo-Tcheugui JB , author
Tait CA , author
Schilsky S , author
Forrester T , author
Kengne AP , author

2015-05-01

The lancet. Diabetes & endocrinology

Dzudie A , author
Njume E , author
Abanda M , author
Aminde L , author
Hamadou B , author
Dzekem B , author
Azabji M , author
Doualla MS , author
Ngowe M , author
Kengne AP , author

2020-03-01

PloS one

Peer N , author
Kengne AP , author

2016-12-01

Global heart

Kengne AP , author
Djouogo CF , author
Dehayem MY , author
Fezeu L , author
Sobngwi E , author
Lekoubou A , author
Mbanya JC , author

2009-12-01

The international journal of lower extremity wounds

Haagsma JA , author
James SL , author
Castle CD , author
Dingels ZV , author
Fox JT , author
Hamilton EB , author
Liu Z , author
Lucchesi LR , author
Roberts NLS , author
Sylte DO , author
Adebayo OM , author
Ahmadi A , author
Ahmed MB , author
Vos T , author

2020-01-01

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

Kengne AP , author
Fezeu LL , author
Awah PK , author
Sobngwi E , author
Dongmo S , author
Mbanya JC , author

2008-09-01

Epilepsia

Mazidi M , author
Gao HK , author
Kengne AP , author

2018-07-01

Scientific reports

Motamed S , author
Mazidi M , author
Safarian M , author
Ghayour-Mobarhan M , author
Moohebati M , author
Ebrahimi M , author
Azarpazhooh MR , author
Heidari-Bakavoli A , author
Esmaily H , author
Baghestani A , author
Ferns GA , author

2019-05-01

ARYA atherosclerosis

Nembaware V , author
Mazandu GK , author
Hotchkiss J , author
Safari Serufuri JM , author
Kent J , author
Kengne AP , author
Anie K , author
Munung NS , author
Bukini D , author
Bitoungui VJN , author
Munube D , author
Chirwa U , author
Wonkam A , author

2020-10-01

Omics : a journal of integrative biology

Masconi K , author
Matsha TE , author
Erasmus RT , author
Kengne AP , author

2015-05-01

Diabetology & metabolic syndrome

Kengne AP , author
Choukem SP , author
Dehayem YM , author
Simo NL , author
Fezeu LL , author
Mbanya JC , author

2006-09-01

Journal of wound care

GBD 2017 Pancreatic Cancer Collaborators , author

2019-10-01

The lancet. Gastroenterology & hepatology

Pasmore Malambo , author
Andre P. Kengne , author
Estelle V. Lambert , author
Anniza De Villers , author
Thandi Puoane , author

2016-06-15

Advances in Epidemiology

Businge CB , author
Longo-Mbenza B , author
Kengne AP , author

2020-08-01

Public health nutrition

Francois FolefackKaze , author
Andre-Pascal Kengne , author
Eric Walter PefuraYone , author
Nelly Sandra NdamFemben , author
Gloria Ashuntantang , author

2013-01-01

As per guidelines and recommendations, screening for renal diseases should be performed at the time of diagnosis of human immuno-deficiency virus (HIV) infection; however, this remains largely unimplemented in many settings across Sub-Saharan Africa. We evaluated the renal function, urinalysis abnormalities and their correlates in HIV-infected individuals who were naïve to highly active antiretroviral therapy (HAART). This was a cross-sectional study of 2 months′ duration involving 104 HIV-infected outpatients naive to HAART (71 women, 68%) attending the HIV clinic of the Yaoundé General Hospital in Cameroon. Renal and urinalysis parameters were measured and the Student t-test and Fischer exact test were used to compare the groups of participants. The mean age and CD4 count were, respectively, 35 ± 10.7 years and 305 ± 202/mL. Fifty-six (54%) patients presented with stages 3 and 4 of HIV infection. Forty-three (41%) patients had urinalysis abnormalities, including proteinuria (36%), leukocyturia (13%) and hematuria (12%). Proteinuria was associated with increased age, advanced stage of HIV infection, decreased CD4 count, hematuria and renal failure (P <0.04). Hematuria and leukocyturia were associated with decreased CD4 count and advanced stage of HIV infection, respectively (P = 0.04). The mean estimated glomerular filtration (eGFR) rate was100.2 ± 32.7 mL/min; three (3%) patients had renal failure (eGFR <60 mL/min) and 45 (43%) patients had reduced kidney function 60 ≤eGFR ≤90 mL/min. There was a high prevalence of decreased kidney function and proteinuria among Cameroonian HIV-infected patients naïve to HAART. Indicators of the severity of HIV infection, including advanced stage and low CD4 count, were associated with urinalysis abnormalities.

Simo N , author
Kuate-Tegueu C , author
Ngankou-Tchankeu S , author
Doumbe J , author
Maiga Y , author
Cesari M , author
Dartigues JF , author
Kengne AP , author
Tabue-Teguo M , author

2020-10-01

PloS one

Eric Walter Pefura-Yone , author
André Pascal Kengne , author
Adamou Dodo Balkissou , author
Julie Raïcha Boulleys-Nana , author
Nelly Rachel Efe-de-Melingui , author
Patricia Ingrid Ndjeutcheu-Moualeu , author
Charles Lebon Mbele-Onana , author
Elvira Christelle Kenmegne-Noumsi , author
Barbara Linda Kolontchang-Yomi , author
Boris Judicaël Theubo-Kamgang , author
Emilienne Régine Ebouki , author
Chrystelle Karen Djuikam-Kamga , author
Christiane Gaelle Magne-Fotso , author
Francine Amougou , author
Liliane Mboumtou , author
Martine Ngo-Yonga , author
Elsie Linda Petchou-Talla , author
Emmanuel Afane-Ze , author
Christopher Kuaban , author

Population-based estimates of asthma and allergic rhinitis in sub-Saharan African adults are lacking. We assessed the prevalence and determinants of asthma and allergic rhinitis in urban adult Cameroonians.A community-based survey was conducted from December 2013 to April 2014 among adults aged 19 years and above (N = 2,304, 57.3% women), selected through multilevel stratified random sampling across all districts of Yaounde (Capital city). Internationally validated questionnaires were used to investigate the presence of allergic diseases. Logistic regressions were employed to investigate the determinants of allergic conditions.Prevalence rates were 2.7% (95% CI: 2.1-3.4) for asthma-ever, 6.9% (5.9-7.9) for lifetime wheezing, 2.9% (92.2-3.6) for current wheezing and 11.4% (10.1-12.7) for self-reported lifetime allergic rhinitis; while 240 (10.4%) participants reported current symptoms of allergic rhinitis, and 125 (5.4%) had allergic rhino-conjunctivitis. The prevalence of current asthma medication use and self-reported asthma attack was 0.8 (0.4-1.2) and 1 (0.6-1.4) respectively. Multivariable adjusted determinants of current wheezing were signs of atopic eczema [2.91 (1.09-7.74)] and signs of allergic rhinitis [3.24 (1.83-5.71)]. Age group 31-40 years [0.27(0.09-0.78), p = 0.016] was an independent protective factor for wheezing. Determinants of current rhinitis symptoms were active smoking [2.20 (1.37-3.54), p<0.001], signs of atopic eczema [2.84 (1.48-5.46)] and current wheezing [3.02 (1.70-5.39)].Prevalence rates for asthma and allergic rhinitis among adults in this population were at the lower tails of those reported in other regions of the world. Beside the classical interrelation between allergic diseases found in this study, active smoking was an independent determinant of allergic rhinitis symptoms. Nationwide surveys are needed to investigate regional variations.

Aminde LN , author
Dzudie A , author
Takah NF , author
Ngu KB , author
Sliwa K , author
Kengne AP , author

2015-04-01

Cardiovascular diagnosis and therapy

Lopes T , author
Zemlin AE , author
Erasmus RT , author
Faber M , author
Kengne AP , author

2020-06-01

BMJ open

Werfalli M , author
Engel ME , author
Musekiwa A , author
Kengne AP , author
Levitt NS , author

2015-11-01

The lancet. Diabetes & endocrinology

Ndadza A , author
Cindi Z , author
Makambwa E , author
Chimusa E , author
Wonkam A , author
Kengne AP , author
Ntsekhe M , author
Dandara C , author

2018-12-01

Omics : a journal of integrative biology

Masconi KL , author
Matsha TE , author
Echouffo-Tcheugui JB , author
Erasmus RT , author
Kengne AP , author

2015-03-01

The EPMA journal

Feteh VF , author
Choukem SP , author
Kengne AP , author
Nebongo DN , author
Ngowe-Ngowe M , author

2016-03-01

BMC nephrology

Davids SFG , author
Matsha TE , author
Peer N , author
Erasmus RT , author
Kengne AP , author

2019-06-01

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Rohina Joshi , author
Mohammed Alim , author
Andre Pascal Kengne , author
Stephen Jan , author
Pallab K Maulik , author
David Peiris , author
Anushka A Patel , author

One potential solution to limited healthcare access in low and middle income countries (LMIC) is task-shifting- the training of non-physician healthcare workers (NPHWs) to perform tasks traditionally undertaken by physicians. The aim of this paper is to conduct a systematic review of studies involving task-shifting for the management of non-communicable disease (NCD) in LMIC.A search strategy with the following terms "task-shifting", "non-physician healthcare workers", "community healthcare worker", "hypertension", "diabetes", "cardiovascular disease", "mental health", "depression", "chronic obstructive pulmonary disease", "respiratory disease", "cancer" was conducted using Medline via Pubmed and the Cochrane library. Two reviewers independently reviewed the databases and extracted the data.Our search generated 7176 articles of which 22 were included in the review. Seven studies were randomised controlled trials and 15 were observational studies. Tasks performed by NPHWs included screening for NCDs and providing primary health care. The majority of studies showed improved health outcomes when compared with usual healthcare, including reductions in blood pressure, increased uptake of medications and lower depression scores. Factors such as training of NPHWs, provision of algorithms and protocols for screening, treatment and drug titration were the main enablers of the task-shifting intervention. The main barriers identified were restrictions on prescribing medications and availability of medicines. Only two studies described cost-effective analyses, both of which demonstrated that task-shifting was cost-effective.Task-shifting from physicians to NPHWs, if accompanied by health system re-structuring is a potentially effective and affordable strategy for improving access to healthcare for NCDs. Since the majority of study designs reviewed were of inadequate quality, future research methods should include robust evaluations of such strategies.

Mashiane JT , author
Monyeki KD , author
Kengne AP , author
Rosina NM , author
Monyeki MS , author

2018-09-01

Cardiovascular journal of Africa

GBD 2017 Mortality Collaborators , author

2018-11-01

Lancet (London, England)

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators , author

2018-11-01

Lancet (London, England)

Krishnamurthi RV , author
deVeber G , author
Feigin VL , author
Barker-Collo S , author
Fullerton H , author
Mackay MT , author
O'Callahan F , author
Lindsay MP , author
Kolk A , author
Lo W , author
Shah P , author
Linds A , author
Jones K , author
GBD 2013 Stroke Panel Experts Group , author

2015-10-01

Neuroepidemiology

Macharia M , author
Kengne AP , author
Blackhurst DM , author
Erasmus RT , author
Matsha TE , author

2014-11-01

Mediators of Inflammation

Mbanya VN , author
Echouffo-Tcheugui JB , author
Akhtar H , author
Mbanya JC , author
Kengne AP , author

2015-03-01

Diabetology & metabolic syndrome

Ameh OI , author
Okpechi IG , author
Dandara C , author
Kengne AP , author

2017-03-01

Omics : a journal of integrative biology

Park JJH , author
Grais RF , author
Taljaard M , author
Nakimuli-Mpungu E , author
Jehan F , author
Nachega JB , author
Ford N , author
Xavier D , author
Kengne AP , author
Ashorn P , author
Socias ME , author
Bhutta ZA , author
Mills EJ , author

2021-05-01

The Lancet. Global health

Caleyachetty R , author
Thomas GN , author
Kengne AP , author
Echouffo-Tcheugui JB , author
Schilsky S , author
Khodabocus J , author
Uauy R , author

2018-08-01

The American journal of clinical nutrition

Kengne AP , author
Mayosi BM , author

2013-05-01

Cardiovascular journal of Africa

Pefura-Yone EW , author
Kengne AP , author
Tagne-Kamdem PE , author
Afane-Ze E , author

2014-07-01

BMJ open

Ekrikpo UE , author
Akpan EE , author
Ekott JU , author
Bello AK , author
Okpechi IG , author
Kengne AP , author

2018-07-01

BMJ open

Echouffo-Tcheugui JB , author
Dzudie A , author
Epacka ME , author
Choukem SP , author
Doualla MS , author
Luma H , author
Kengne AP , author

2012-06-01

Primary care diabetes

Pule GD , author
Ngo Bitoungui VJ , author
Chetcha Chemegni B , author
Kengne AP , author
Antonarakis S , author
Wonkam A , author

2015-09-01

Omics : a journal of integrative biology

GBD 2016 Disease and Injury Incidence and Prevalence Collaborators , author

2017-09-01

Lancet (London, England)

Noubiap JJ , author
Naidoo J , author
Kengne AP , author

2015-06-01

World journal of diabetes

Irina, Balieva , author
Anastase, Dzudie , author
Friedrich, Thienemann , author
Mahmoud, U Sani , author
Andre, Pascal Kengne , author
Karen, Sliwa , author
Adriaan, A Voors , author
Ana, O Mocumbi , author
Kamilu, Karaye , author
Okechukwu, S Ogah , author

2017-01-01

Ndadza A , author
Muyambo S , author
Mnta P , author
Wonkam A , author
Chimusa E , author
Kengne AP , author
Ntsekhe M , author
Dandara C , author

2021-08-01

Journal of thrombosis and haemostasis : JTH

Dzudie A , author
Hoover D , author
Kim H , author
Ajeh R , author
Adedimeji A , author
Shi Q , author
Yone WP , author
Nforniwe DN , author
Njie KT , author
Kengne AP , author
Ebasone VP , author
Barche B , author
Cecile ZBA , author
Nash D , author
Yotebieng M , author
Anastos K , author

2020-08-01

NCD Risk Factor Collaboration (NCD-RisC) , author

2021-03-01

eLife

Malambo P , author
Kengne AP , author
Lambert EV , author
De Villers A , author
Puoane T , author

2017-02-01

BMC public health

Dzudie A , author
Kengne AP , author
Thienemann F , author
Sliwa K , author

2014-07-01

BMJ open

Joshi R , author
Kengne AP , author
Hersch F , author
Weber MB , author
McGuire H , author
Patel A , author

2018-09-01

Boateng D , author
Agyemang C , author
Beune E , author
Meeks K , author
Smeeth L , author
Schulze MB , author
Addo J , author
de-Graft Aikins A , author
Galbete C , author
Bahendeka S , author
Danquah I , author
Agyei-Baffour P , author
Klipstein-Grobusch K , author

2018-01-01

International journal of cardiology

Georgia E. Ritchie , author
Andre Pascal Kengne , author
Bruce Neal , author

OBJECTIVE — To assess the utility of a point-of-care (POC) capillary blood glucose measurement as compared with routine clinical parameters in predicting undiagnosed diabetes in a low-resource rural India setting. RESEARCH DESIGN AND METHODS — Nine hundred and ninety-four participants aged �30 years and stratified by age and sex were randomly selected from 20 villages in India. A clinical questionnaire, sampling for laboratory venous fasting plasma glucose (FPG), and POC capillary blood glucose assay were performed simultaneously. Diabetes diagnosis was based on the World Health Organization (WHO) definition using FPG. The capacity of the POC glucose to predict the presence of diabetes was assessed and compared with the questionnaire using area under the receiver operating characteristic curves (AUCs). RESULTS — The AUC for POC glucose alone in predicting diabetes was 0.869 (95 % CI 0.810–0.929). This was significantly better (P � 0.001 for AUC comparison) than the models based upon clinical variables alone (AUC for the best clinical model including age, BMI, hypertension, waist circumference: 0.694 [95 % CI 0.621–0.766]). POC glucose appropriately reclassified the risk of up to one-third of participants ranked according to the clinical models. Adding the clinical variables to the POC glucose assay did not significantly improve the discriminatory capability beyond that achieved with the POC glucose measurement alone (all P � 0.37). CONCLUSIONS — POC glucose testing appears to be a simple and reliable tool for identifying undiagnosed diabetes in a high-risk, resource-poor rural population. However, studies evaluating the cost effectiveness of introducing POC glucose testing are needed prior to widespread implementation. The prevalence of type 2 diabetes is rapidly increasing around the world (1). Developing countries are facing the largest increases both in absolute and relative terms (1). It is predicted that this will have devastating consequences on the economies and health systems of these countries. Successful prevention and

Cindy George , author
Tandi E Matsha , author
Florence E Davidson , author
Julia H Goedecke , author
Rajiv T Erasmus , author
Andre Pascal Kengne , author

2020-05-01

International Journal of Nephrology and Renovascular Disease

Mazidi M , author
Kengne AP , author
Banach M , author
Lipid and Blood Pressure Meta-analysis Collaboration Group , author

2017-08-01

Pharmacological research

van der Leeuw J , author
Visseren FL , author
Woodward M , author
Zoungas S , author
Kengne AP , author
van der Graaf Y , author
Glasziou P , author
Hamet P , author
MacMahon S , author
Poulter N , author
Grobbee DE , author
Chalmers J , author

2014-10-01

Hypertension (Dallas, Tex. : 1979)

Zoungas S , author
Chalmers J , author
Kengne AP , author
Pillai A , author
Billot L , author
de Galan B , author
Marre M , author
Neal B , author
Harrap S , author
Poulter N , author
Patel A , author

2010-06-01

Diabetes research and clinical practice

Aminde LN , author
Dzudie A , author
Kengne AP , author
Ndjebet J , author
Mapoh S , author
Kuelang X , author
Kamdem F , author
Mbatchou Ngahane BH , author
Doualla MS , author
Ngu KB , author
Sliwa K , author
Thienemann F , author

2017-09-01

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Peer N , author
Abrahams N , author
Kengne AP , author

2020-09-01

Global heart

GBD 2017 HIV collaborators , author

2019-08-01

The lancet. HIV

Mohsen Mazidi , author
Andre Pascal Kengne , author
Hassan Vatanparast , author

2017-01-01

Background and Purpose. Leukocyte telomere length (LTL) is a biomarker of biologic age. Whether food security status modulates LTL is still unknown. We investigated the association between food security and LTL in participants of the 1999–2002 US National Health and Nutrition Examination Survey (NHANES). Methods. Analysis of covariance (ANCOVA) was used to evaluate the association between food security categories and LTL controlling for sex, race, and education and accounting for the survey design and sample weights. Results. We included 10,888 participants with 5228 (48.0%) being men. They were aged on average 44.1 years. In all, 2362 (21.7%) had less than high school, 2787 (25.6%) had achieved high school, while 5705 (52.5%) had done more than high school. In sex-, race-, and education-adjusted ANCOVA, average LTL (T/S ratio) for participants with high food security versus those with marginal, low, or very low food security was 1.32 versus 1.20 for the age group 25–35 years and 1.26 versus 1.11 for the 35–45 years, (p<0.001). Conclusion. The association between food insecurity and LTL shortening in young adults suggest that some of the future effects of food insecurity on chronic disease risk in this population could be mediated by telomere shortening.

Mohsen Mazidi , author
Hong-kai Gao , author
Nitin Shivappa , author
Michael D. Wirth , author
James R Hebert , author
Andre Pascal Kengne , author

2017-01-01

Abstract Background It has been suggested that trans fatty acids (TFAs) play an important role in cardiovascular diseases. We investigated the association between plasma TFAs and the dietary inflammatory index (DII) ™ in US adults. Methods National Health and Nutrition Examination Survey (NHANES) participants with data on plasma TFAs measured from 1999 to 2010 were included. Energy-adjusted-DII ™ (E-DII ™) expressed per 1000 kcal was calculated from 24-h dietary recalls. All statistical analyses accounted for the survey design and sample weights. Results Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age of the population was 47.1 years overall, 47.8 years for men and 46.5 years for women (p = 0.09). After adjustment for C-reactive protein, body-mass-index, smoking, race, age, education, and marital status in linear regressions, trans 9-hexadecenoic acid [β coefficient 0.068 (95% CI: 0.032 to 0.188)], trans 11-octadecenoic acid [β coefficient 0.143 (95% CI: 0.155 to 0.310)], trans 9-octadecenoic acid [β coefficient 0.122 (95% CI: 0.120 to 0.277)], trans 9, and trans 12-octadienoic acid [β coefficient 0.103 (95% CI: 0.090 to 0.247)] were positively associated with the DII (all p < 0.001). Conclusion The association of plasma TFAs with a marker of dietary inflammation suggests an underlying mechanism in the initiation and progression of cardiovascular diseases.

GBD 2016 Mortality Collaborators , author

2017-09-01

Lancet (London, England)