EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2019-07-01
End Date 2022-06-22
Project Code TMA2017CDF-1865
Status Active


Emerging and Re-emerging Arboviral Infections in Nairobi, Kenya

Host Organisation

Institution Country
University of Nairobi Kenya

Current Organisation

University of Nairobi

Current Job Title

Tutorial Fellow

Students Supervised

Type Name Title University Start Date End Date
Moses Muia Masika


Role Committee/board Start Date End Date
Review Editor Frontiers in Tropical Diseases 2021


Institution Degree Year
University of Nairobi, Kenya MBCHB 2008-12-19
University of Nairobi, Kenya MSc. TID 2014-12-04

Areas Of Specialisation

Infectious Diseases Arbovirology Zoonoses Virology One Health




Several alphaviruses, such as chikungunya (CHIKV) and Onyong-nyong (ONNV), are endemic in Kenya and often cause outbreaks in different parts of the country. We assessed the seroprevalence of alphaviruses in patients with acute febrile illness in two geographically distant areas in Kenya with no previous record of alphavirus outbreaks. Blood samples were collected from febrile patients in health facilities located in the rural Taita-Taveta County in 2016 and urban Kibera informal settlement in Nairobi in 2017 and tested for CHIKV IgG and IgM antibodies using an in-house immunofluorescence assay (IFA) and a commercial ELISA test, respectively. A subset of CHIKV IgG or IgM antibody-positive samples were further analyzed using plaque reduction neutralization tests (PRNT) for CHIKV, ONNV, and Sindbis virus. Out of 537 patients, 4 (0.7%) and 28 (5.2%) had alphavirus IgM and IgG antibodies, respectively, confirmed on PRNT. We show evidence of previous and current exposure to alphaviruses based on serological testing in areas with no recorded history of outbreaks

Hafso Mohamed Abdulle, Moses Muia Masika, Julius Otieno Oyugi , Hafso et. al
Pan Afr Med J

Introduction: corona viruses are highly contagious and healthcare workers are at a higher risk of contracting the disease. The objective of this study was to assess the level of knowledge, risk perception, preparedness for coronavirus disease 2019 and vaccine acceptability among healthcare workers in Kenya.

Methods: a cross-sectional study was conducted from December 2020 to January 2021. A link to an online self-administered questionnaire was disseminated to health workers across the country. SPSS version 20 was used for data analysis. Bivariate correlation analyses were used to determine associations between variables. P-value of <0.05 was considered statistically significant.

Results: a total of 997 participants were enrolled in the study. About half (53%) of the participants were female. The mean age was 36.54 years (SD = 8.31) and 46% of the participants were aged between 31-40 years. The overall knowledge score of health workers for COVID-19 was 80%. Most of the health workers (89%) perceived that they were at high risk of infection. Seventy-two percent of the participants felt that they were either partially or fully prepared to handle patients with COVID-19. Overall, 71% of all health workers would take a vaccine if provided free by the government.

Conclusion: health workers´ knowledge on transmission, clinical manifestations and risk factors for development of severe COVID-19 was good. Majority of the health workers perceived the risk of infection with COVID-19 as high and a significant number felt that they were not fully prepared to handle the pandemic. Majority of health workers would take a COVID-19 vaccine.


Moses Masika
Name Country Institution
Moses Masika Kenya University of Nairobi
1. To determine the prevalence of arboviral infections among patients with acute febrile illness in Kibera slum. 2. To identify any novel or emerging pathogens within the study population 3. To assess the genetic diversity of arboviruses isolated in febrile patients in the study area
Ushirika Medical Clinic, Kibera Community Health Centre and Langata Health Centre
Study Design:
Observational Cross-sectional Study
Febrile patients
Start Date:
End Date:

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