||Senior Fellowship (SF)
Impact of schistosoma hematobium infection on immunological and
clinical aspects of P. falciparum malaria in children
This project aimed to study the impact of S. haematobium infection on P.
falciparum malaria induced immune response and clinical features in
school children residing in two communities in the vicinity of Lambaréné
(PK15 and PK17), where the malaria incidence rate is 1.3 person-years.
The research questions to be answered by the project are:
1. How are plasmodia-specific pro-inflammatory Th1 and Th17
immune responses affected by coinfection with S. haematobium?
2. How does S. haematobium infection influence the clinical and
parasitological profile of P.falciparum malaria?
|Medical Research Unit Albert Schweitzer Hospital
||Albert Schweitzer Hospital
||Leiden University, The Netherlands
Immunology studies of schisto/malaria co-infection
Results & Outcomes
754 school aged children were screened and 601 were included for
follow-up. At baseline 141(19%) of the participants were positive for P.
falciparum, 225/741(30%) were positive for Schistosoma hematobium,
and 225/642 (33%) for soil-transmitted helminthes infestation: 128
(20.0%) for A. lumbricoides; 139 (22.0%) for T. trichiura; and 43 (7.0%) for
hookworm. All infected children were treated accordingly and followedup.
Preliminary results show that that the presence of P. falciparum
infection was marked by an increase in innate and adaptive immune
responsiveness while S. haematobium infection was characterized by an
increased chemokine profile, with at the same time, lower pro
inflammatory markers. When the study subjects were split into single
infected and co-infected groups no effect of S. haematobium on the
immune response of P. falciparum infected subjects was observed,
neither for the innate nor for the adaptive component of the immune
response. Therefore there no is effect of S. haematobium on the
cytokine profile of subjects co-infected with P. falciparum.
In capacity building the following achievements were made:
• GCP, GCLP and bio-ethics training of the study investigators and
• 4 MSc students were enrolled at various institutions and
supervised by the Senior Fellow. 3 MSc students have completed their
• 1 PhD student has been registered and is being co-supervised
by the Senior Fellow.
• Training in laboratory techniques e.g., flow cytometry and in
vitro culture techniques and equipment service e.g. training on the BD
Accuri flow cytometry platform was undertaken by the PhD student and
the CERMEL Head of Research Laboratory.
|Ayola A, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, Honkpehedji YJ, Dejon Agobe JC, Kenguele HM, Massinga- Loembe M, Agnandji ST, Mordmüller B, Ramharter M, Yazdanbakhsh M, Kremsner PG, Lell B. Randomized, Controlled, Assessor-Blind Clinical Trial To Assess the Efficacy of Singleversus Repeated-Dose Albendazole To Treat Ascaris lumbricoides, Trichuris trichiura, and Hookworm Infection. Antimicrobial Agents in Chemotherapy 2014, 58(5):2535.
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