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Dr Bruno Senghor

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2020-01-01
End Date 2022-12-31
Project Code TMA2018CDF-2370
Status Active

Title

Hybridization as a driver for the spread of schistosomiasis: an integrative approach to evaluate the invasive capacity of schistosome hybrids under praziquantel pressure

Host Organisation

Institution Country
Institut de Recherche pour le Développement - Senegal (IRD) Senegal

Current Organisation

Institut de recherche pour le developpement (IRD)

Current Job Title

Researcher at IRD

Education

Institution Degree Year
Cheikh Anta DIOP University, Senegal PhD 2014-12-22

Areas Of Specialisation

Neglected Infectious Diseases (NID)

Publications

Urinary schistosomiasis in three different water-access in the Senegal River Basin: monitoring praziquantel efficacy and re-infection levels
Authors:
Bruno SENGHOR , author
Eglantine Mathieu-Begné , author
Olivier Rey , author
Souleymane Doucouré , author
Doudou Sow , author
Bocar Diop , author
Mariama Sène , author
Jérôme Boissier , author
Cheikh Sokhna , author
Date:
2022-04-22
Journal:
Content:
Identifiers:
DOI: 10.21203/rs.3.rs-1435133/v1
Description of ‘Bacillus dakarensis’ sp. nov., ‘Bacillus sinesaloumensis’ sp. nov., ‘Gracilibacillus timonensis’ sp. nov., ‘Halobacillus massiliensis’ sp. nov., ‘Lentibacillus massiliensis’ sp. nov., ‘Oceanobacillus senegalensis’ sp. nov., ‘Oceanobacillus timonensis’ sp. nov., ‘Virgibacillus dakarensis’ sp. nov. and ‘Virgibacillus marseillensis’ sp. nov., nine halophilic new species isolated from human stool
Authors:
Date:
2017-02-01
Journal:
New Microbes New Infect
Content:
We report the main characteristics of 'Bacillus dakarensis' P3515(T) sp. nov., 'Bacillus sinesaloumensis' P3516(T) sp. nov., 'Gracilibacillus timonensis' P2481(T) sp. nov., 'Halobacillus massiliensis' P3554(T) sp. nov., 'Lentibacillus massiliensis' P3089(T) sp. nov., 'Oceanobacillus senegalensis' P3587(T) sp. nov., 'Oceanobacillus timonensis' P3532(T) sp. nov., 'Virgibacillus dakarensis' P3469(T) sp. nov. and 'Virgibacillus marseillensis' P3610(T) sp. nov., that were isolated in 2016 from salty stool samples (\textgreater/=1.7% NaCl) from healthy Senegalese living at Dielmo and N'diop, two villages in Senegal.
Identifiers:
Taxono-genomics description of Bacillus dakarensis sp. nov., Bacillus sinesaloumensis sp. nov., and Bacillus massiliogabonensis sp. nov., three new species isolated from human stools
Authors:
Date:
2020-07-01
Journal:
Content:
Identifiers:
Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal.
Authors:
Senghor B , author
Diallo A , author
Sylla SN , author
Doucouré S , author
Ndiath MO , author
Gaayeb L , author
Djuikwo-Teukeng FF , author
Bâ CT , author
Sokhna C , author
Date:
2014-01-01
Journal:
Content:
Identifiers:
PMID: 24387599
PMC: PMC3882112
DOI: 10.1186/1756-3305-7-5
Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period.
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Sylla SN , author
Seye M , author
Talla I , author
Bâ CT , author
Diallo A , author
Sokhna C , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
PMID: 26156522
PMC: PMC4496924
DOI: 10.1186/s13071-015-0980-5
‘Gracilibacillus phocaeensis’ sp. nov., ‘Sediminibacillus massiliensis’ sp. nov. and ‘Virgibacillus ndiopensis’ sp. nov., three halophilic species isolated from salty human stools by culturomics
Authors:
Date:
2017-11-01
Journal:
New Microbes and New Infections
Content:
Identifiers:
Study of the snail intermediate hosts of urogenital schistosomiasis in Niakhar, region of Fatick, West central Senegal.
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Seye M , author
Talla I , author
Diallo A , author
Bâ CT , author
Sokhna C , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
PMID: 26246374
PMC: PMC4527339
DOI: 10.1186/s13071-015-1030-z
Bulinus senegalensis and Bulinus umbilicatus Snail Infestations by the Schistosoma haematobium Group in Niakhar, Senegal
Authors:
Papa Mouhamadou Gaye , author
Souleymane Doucoure , author
Bruno Senghor , author
Babacar Faye , author
Ndiaw Goumballa , author
Mbacké Sembène , author
Coralie L’Ollivier , author
Philippe Parola , author
Stéphane Ranque , author
Doudou Sow , author
Cheikh Sokhna , author
Date:
2021-07-08
Journal:
Pathogens
Content:
Identifiers:
DOI: 10.3390/pathogens10070860
Description of Gracilibacillus phocaeensis sp. nov., a new halophilic bacterium isolated from Senegalian human stool
Authors:
Date:
2020-11-01
Journal:
Content:
Identifiers:
Molecular characterization of schistosome cercariae and their Bulinus snail hosts from Niakhar, a seasonal transmission focus in central Senegal
Authors:
Bruno SENHGOR
Date:
2023-02-01
Journal:
Current Research in Parasitology & Vector-Borne Diseases (CRPVBD)
Content:

Bulinus senegalensis and Bulinus umbilicatus, two sympatric freshwater snails found in temporal ponds in Senegal, were thought to be involved in the transmission of Schistosoma haematobium and/or Schistosoma curassoni. To better understand the role of these Bulinus species in the transmission of human and animal Schistosoma species, B. senegalensis and B. umbilicatus were collected in 2015, during a malacological survey, from a temporal pond in Niakhar, central Senegal. Snails were induced to shed cercariae on two consecutive days. Individual cercariae from each snail were collected and preserved for molecular identification. Infected snails were identified by analysis of a partial region of the cytochrome c oxidase subunit 1 (cox1) gene. Six individual cercariae shed from each infected snail were identified by analyses of the cox1, nuclear ITS and partial 18S rDNA regions. Of the 98 snails collected, one B. senegalensis had a mixed infection shedding S. haematobium, S. bovis and S. haematobium-S. bovis hybrid cercariae and one B. umbilicatus was found to be shedding only S. haematobium. These data provide molecular confirmation for B. senegalensis transmitting S. bovis and S. haematobium-S. bovis hybrids in Senegal. The multiple Bulinus species involved in the human urogenital schistosomiasis in Senegal provides a high force of transmission warranting detailed mapping, surveillance and regular treatment of at-risk populations.

 
Identifiers:
Not Informed: not informed
Gut microbiota diversity according to dietary habits and geographical provenance
Authors:
Bruno Senghor , author
Cheikh Sokhna , author
Raymond Ruimy , author
Jean-Christophe Lagier , author
Date:
2018-02-01
Journal:
Human Microbiome Journal
Content:
Identifiers:
DOI: 10.1016/j.humic.2018.01.001
Impact of Annual Praziquantel Treatment on Urogenital Schistosomiasis in a Seasonal Transmission Focus in Central Senegal.
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Seye M , author
Diallo A , author
Talla I , author
Bâ CT , author
Sokhna C , author
Date:
2016-03-01
Journal:
Content:
Identifiers:
PMID: 27015646
PMC: PMC4807842
DOI: 10.1371/journal.pntd.0004557
Phylogeny of seven Bulinus species originating from endemic areas in three African countries, in relation to the human blood fluke Schistosoma haematobium.
Authors:
Zein-Eddine R , author
Djuikwo-Teukeng FF , author
Al-Jawhari M , author
Senghor B , author
Huyse T , author
Dreyfuss G , author
Date:
2014-01-01
Journal:
Content:
Identifiers:
PMID: 25528261
PMC: PMC4295282
DOI: 10.1186/s12862-014-0271-3
Salt in stools is associated with obesity, gut halophilic microbiota and Akkermansia muciniphila depletion in humans
Authors:
Date:
2018-09-01
Journal:
September 2018International journal of obesity
Content:
Identifiers:
Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese
Authors:
Date:
2019-01-01
Journal:
Antonie van Leeuwenhoek volume
Content:
Identifiers:
Sediminibacillus massiliensis sp. nov., a moderately halophilic, Gram-positive bacterium isolated from a stool sample of a young Senegalese man.
Authors:
Date:
2018-01-01
Journal:
Antonie Van Leeuwenhoek International = Journal of General and Molecular Microbiology, 111 (7), 1225-1236. ISSN 0003-6072
Content:
Identifiers:

Projects

Hybridization as a driver for the spread of Schistosomiasis: an integrative approach to evaluate the
Fellow:
Bruno Senghor
Collaborators:
Name Country Institution
Bruno Senghor Senegal IRD
Cheikh Sokhna Senegal IRD
Jérôme Boissier France IHPE PERPIGNAN
Olivier Rey France IHPE PERPIGNAN
Objectives:
The objectives are to (i) determine the current prevalence and intensities of human schistosomiasis, (ii) study the outcomes of S. haematobium X S. bovis hybrids on snail infectivity, (iii) evaluate the sensitivity of hybrids schistosome populations to PZQ according to parasite genetic introgression levels, (iv) characterize the frequency of hybrids and their level of genomic introgression.
Sites:
Senegal River Basin
Study Design:
In this study, we will use an integrative approach combining a genetic monitoring study of the parasite communities infecting human populations in areas with high hybrid prevalence in Senegal before and after repeated PZQ treatment. Parental and hybrid life history traits (i.e. sensibility to PZQ; host spectrum) will be investigated in controlled laboratory experiments.
Subjects:
schistosomiais
Outcomes:
Primary Outcome Measures: The cure rate (CR) of the treatments and Egg Reduction Rates (ERR). The CRs will be measured, as the number of fully cured children and the ERRs of each child is the reduction of the number of excreted eggs/ 10 mls of urine, after PZQ treatment. Secondary Outcome Measures: The frequency of hybrids and the level of genomic introgression between S. bovis and S. haematobium. These outcome measures will be obtained after schistosome molecular analysis. The frequency of hybrids will be measured by quantification of the numbers of hybrids and pure schistosome miracidia recovered from infected children (pre- and post-PZQ treatment). For hybrid parasites, the genomic introgression level will be measured by SNP's distributed across the parasite genome
Start Date:
2021-01-01
End Date:
2023-03-02

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