EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2020-01-01
End Date 2022-12-31
Project Code TMA2018CDF-2370
Status Active

Title

Hybridization as a driver for the spread of schistosomiasis: an integrative approach to evaluate the invasive capacity of schistosome hybrids under praziquantel pressure

Host Organisation

Institution Country
Institut de Recherche pour le Développement - Senegal (IRD) Senegal

Current Organisation

Institut de recherche pour le developpement (IRD)

Current Job Title

Researcher at IRD

Education

Institution Degree Year
Cheikh Anta DIOP University, Senegal PhD 2014-12-22

Areas Of Specialisation

Neglected Infectious Diseases (NID)

Publications

Authors:
Date:
2017-02-01
Journal:
New Microbes New Infect
Content:
We report the main characteristics of 'Bacillus dakarensis' P3515(T) sp. nov., 'Bacillus sinesaloumensis' P3516(T) sp. nov., 'Gracilibacillus timonensis' P2481(T) sp. nov., 'Halobacillus massiliensis' P3554(T) sp. nov., 'Lentibacillus massiliensis' P3089(T) sp. nov., 'Oceanobacillus senegalensis' P3587(T) sp. nov., 'Oceanobacillus timonensis' P3532(T) sp. nov., 'Virgibacillus dakarensis' P3469(T) sp. nov. and 'Virgibacillus marseillensis' P3610(T) sp. nov., that were isolated in 2016 from salty stool samples (\textgreater/=1.7% NaCl) from healthy Senegalese living at Dielmo and N'diop, two villages in Senegal.
Identifiers:
Authors:
Senghor B , author
Diallo A , author
Sylla SN , author
Doucouré S , author
Ndiath MO , author
Gaayeb L , author
Djuikwo-Teukeng FF , author
Bâ CT , author
Sokhna C , author
Date:
2014-01-01
Journal:
Content:
Identifiers:
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Sylla SN , author
Seye M , author
Talla I , author
Bâ CT , author
Diallo A , author
Sokhna C , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Seye M , author
Talla I , author
Diallo A , author
Bâ CT , author
Sokhna C , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
Authors:
Papa Mouhamadou Gaye , author
Souleymane Doucoure , author
Bruno Senghor , author
Babacar Faye , author
Ndiaw Goumballa , author
Mbacké Sembène , author
Coralie L’Ollivier , author
Philippe Parola , author
Stéphane Ranque , author
Doudou Sow , author
Cheikh Sokhna , author
Date:
2021-07-08
Journal:
Pathogens
Content:
Identifiers:
Authors:
Bruno Senghor , author
Cheikh Sokhna , author
Raymond Ruimy , author
Jean-Christophe Lagier , author
Date:
2018-02-01
Journal:
Human Microbiome Journal
Content:
Identifiers:
Authors:
Senghor B , author
Diaw OT , author
Doucoure S , author
Seye M , author
Diallo A , author
Talla I , author
Bâ CT , author
Sokhna C , author
Date:
2016-03-01
Journal:
Content:
Identifiers:
Authors:
Zein-Eddine R , author
Djuikwo-Teukeng FF , author
Al-Jawhari M , author
Senghor B , author
Huyse T , author
Dreyfuss G , author
Date:
2014-01-01
Journal:
Content:
Identifiers:
Authors:
Date:
2018-09-01
Journal:
September 2018International journal of obesity
Content:
Identifiers:
Authors:
Date:
2018-01-01
Journal:
Antonie Van Leeuwenhoek International = Journal of General and Molecular Microbiology, 111 (7), 1225-1236. ISSN 0003-6072
Content:
Identifiers:

Projects

Fellow:
Bruno Senghor
Collaborators:
Name Country Institution
Bruno Senghor Senegal IRD
Cheikh Sokhna Senegal IRD
Jérôme Boissier France IHPE PERPIGNAN
Olivier Rey France IHPE PERPIGNAN
Objectives:
The objectives are to (i) determine the current prevalence and intensities of human schistosomiasis, (ii) study the outcomes of S. haematobium X S. bovis hybrids on snail infectivity, (iii) evaluate the sensitivity of hybrids schistosome populations to PZQ according to parasite genetic introgression levels, (iv) characterize the frequency of hybrids and their level of genomic introgression.
Sites:
Senegal River Basin
Study Design:
In this study, we will use an integrative approach combining a genetic monitoring study of the parasite communities infecting human populations in areas with high hybrid prevalence in Senegal before and after repeated PZQ treatment. Parental and hybrid life history traits (i.e. sensibility to PZQ; host spectrum) will be investigated in controlled laboratory experiments.
Subjects:
schistosomiais
Outcomes:
Primary Outcome Measures: The cure rate (CR) of the treatments and Egg Reduction Rates (ERR). The CRs will be measured, as the number of fully cured children and the ERRs of each child is the reduction of the number of excreted eggs/ 10 mls of urine, after PZQ treatment. Secondary Outcome Measures: The frequency of hybrids and the level of genomic introgression between S. bovis and S. haematobium. These outcome measures will be obtained after schistosome molecular analysis. The frequency of hybrids will be measured by quantification of the numbers of hybrids and pure schistosome miracidia recovered from infected children (pre- and post-PZQ treatment). For hybrid parasites, the genomic introgression level will be measured by SNP's distributed across the parasite genome
Start Date:
2021-01-01
End Date:
2023-03-02

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