Determining the Role of Fc gamma Receptor (FCGR) gene polymorphisms in HIV infection progression and
treatment outcomes in Ghanaian Adults Using Next Generation Sequencing (FCGR-HIV)
Project 1: To investigate the levels of three APPs: C-reactive protein (CRP), serum ferritin and serum transferrin, and Full Blood Count (FBC) indices in children with the HbAS and HbAA genotype and how they associate with P. falciparum infection.
Project 2: To determine the prevalence of sickle cell disorders among children aged 1-12 years, and also assessed the influence of these disorders on malaria infection, anaemia and the growth and development of children.
The study observed that children and pregnant women had higher asymptomatic infections, making them highly at risk of re-infections and reserviors of transmission. The parasite diversity detected gave an indication of higher ongoing transmission intensity than might have been detected. The prevalence of Pfmdr1 as a marker of potential drug resistance associated with ACT showed a similar trend of an emerging drug resistance and / tolerance in other parts of Sub Saharan Africa. The heterozygous α -thalassemic condition conferred protection against infection in children, however, the increased risk of P. falciparum infection when heterozygous for α–thalassaemia in adults and pregnant women is unclear. There is evidence of high antibody responses against these two potential transmission blocking antigens in the endemic area
|Lamptey, H., Ofori, M. F., Kusi, K. A., Adu, B., Owusu-Yeboa, E., Kyei-Baafour, E., Arku, A. T., Bosomprah, S., Alifrangis, M., & Quakyi, I. A. (2018). The prevalence of submicroscopic Plasmodium falciparum gametocyte carriage and multiplicity of infection in children, pregnant women and adults in a low malaria transmission area in Southern Ghana. Malaria journal, 17(1), 331. https://doi.org/10.1186/s12936-018-2479-y
|Lamptey, H., Ofori, M. F., Adu, B., Kusi, K. A., Dickson, E. K., Quakyi, I., & Alifrangis, M. (2019). Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana. BMC research notes, 12(1), 134. https://doi.org/10.1186/s13104-019-4181-8
|Oppong, M., Lamptey, H., Kyei-Baafour, E. Ofori E A, Tornyigah B, Kweku M, Ofori M. F. Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study. Malar J 19, 426 (2020). https://doi.org/10.1186/s12936-020-03500-5
|Lamptey, H., Bonney, E. Y., Adu, B., & Kyei, G. B. (2021). Are Fc Gamma Receptor Polymorphisms Important in HIV-1 Infection Outcomes and Latent Reservoir Size?. Frontiers in immunology, 12, 656894. https://doi.org/10.3389/fimmu.2021.656894
|Bonney, E. Y., Lamptey, H., Aboagye, J. O., Zaab-Yen Abana, C., Boateng, A. T., Quansah, D., Obo-Akwa, A., Ganu, V. J., Puplampu, P., Kyei, G. B., & H-CRIS Massive Action Team (2021). Unwillingness of patients in Ghana to interrupt antiretroviral therapy for HIV cure research. Journal of virus eradication, 7(1), 100027. https://doi.org/10.1016/j.jve.2020.100027