EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call EDCTP-AREF Preparatory Fellowships (PF)
Programme EDCTP2
Start Date 2021-10-01
End Date 2022-10-31
Project Code TMA2018PF-2535
Status Active

Title

Determining the Role of Fc gamma Receptor (FCGR) gene polymorphisms in HIV infection progression and treatment outcomes in Ghanaian Adults Using Next Generation Sequencing (FCGR-HIV)

Objectives

Project 1: To investigate the levels of three APPs: C-reactive protein (CRP), serum ferritin and serum transferrin, and Full Blood Count (FBC) indices in children with the HbAS and HbAA genotype and how they associate with P. falciparum infection. Project 2: To determine the prevalence of sickle cell disorders among children aged 1-12 years, and also assessed the influence of these disorders on malaria infection, anaemia and the growth and development of children.

Host Organisation

Institution Country
Department of Experimental Biology Netherlands

Participants

Name Institution Country
Helena Lamptey Noguchi Memorial Institute for Medical Research, University of Ghana Ghana

Study Design

Cross sectional study

Sites

Asutuare, Hohoe and Eastern Region

Phd Study

Title University Start Date End Date
The impact of naturally acquired immunity and antimalarial drugs on Plasmodium falciparum gametocytes in a malaria endemic area in Ghana School of Public Health, University of Ghana 2012-08-02 2017-07-31

Students Supervised

Type Name Title University Start Date End Date
MPhil Mary Tetteh Malaria Related Anaemia Among Children in the Fanteakwa District in The Eastern Region of Ghana Kwame Nkrumah University of Science and Technology, Kumasi 2018 2020
Mphil Mavis Oppong Prevalence of Sickle Cell Disorders and Malaria Infection in Children Aged 1-12 Years in The Volta Region, Ghana: A Community-Based Study School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana 2018 2020

Results & Outcomes

The study observed that children and pregnant women had higher asymptomatic infections, making them highly at risk of re-infections and reserviors of transmission. The parasite diversity detected gave an indication of higher ongoing transmission intensity than might have been detected. The prevalence of Pfmdr1 as a marker of potential drug resistance associated with ACT showed a similar trend of an emerging drug resistance and / tolerance in other parts of Sub Saharan Africa. The heterozygous α -thalassemic condition conferred protection against infection in children, however, the increased risk of P. falciparum infection when heterozygous for α–thalassaemia in adults and pregnant women is unclear. There is evidence of high antibody responses against these two potential transmission blocking antigens in the endemic area

Publications

Lamptey, H., Ofori, M. F., Kusi, K. A., Adu, B., Owusu-Yeboa, E., Kyei-Baafour, E., Arku, A. T., Bosomprah, S., Alifrangis, M., & Quakyi, I. A. (2018). The prevalence of submicroscopic Plasmodium falciparum gametocyte carriage and multiplicity of infection in children, pregnant women and adults in a low malaria transmission area in Southern Ghana. Malaria journal, 17(1), 331. https://doi.org/10.1186/s12936-018-2479-y
Lamptey, H., Ofori, M. F., Adu, B., Kusi, K. A., Dickson, E. K., Quakyi, I., & Alifrangis, M. (2019). Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana. BMC research notes, 12(1), 134. https://doi.org/10.1186/s13104-019-4181-8
Oppong, M., Lamptey, H., Kyei-Baafour, E. Ofori E A, Tornyigah B, Kweku M, Ofori M. F. Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study. Malar J 19, 426 (2020). https://doi.org/10.1186/s12936-020-03500-5
Lamptey, H., Bonney, E. Y., Adu, B., & Kyei, G. B. (2021). Are Fc Gamma Receptor Polymorphisms Important in HIV-1 Infection Outcomes and Latent Reservoir Size?. Frontiers in immunology, 12, 656894. https://doi.org/10.3389/fimmu.2021.656894
Bonney, E. Y., Lamptey, H., Aboagye, J. O., Zaab-Yen Abana, C., Boateng, A. T., Quansah, D., Obo-Akwa, A., Ganu, V. J., Puplampu, P., Kyei, G. B., & H-CRIS Massive Action Team (2021). Unwillingness of patients in Ghana to interrupt antiretroviral therapy for HIV cure research. Journal of virus eradication, 7(1), 100027. https://doi.org/10.1016/j.jve.2020.100027

Publications

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