EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles
Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-04-01
End Date 2020-03-01
Project Code TMA2015CDF976
Status Active

Title

Cluster randomized community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations

Objectives

• To quantify the impact of twice yearly versus yearly community treatment (treatment strategies and • delivery systems) in reducing parasitological and entomological LF transmission indices in hotspot areas • Assess the impact of the treatment on other helminth infections • To evaluate the costs and cost-effectiveness of twice yearly treatment in reducing disease transmission. • To assess the extent to which the twice-yearly treatment is acceptable to the community and feasible, given the health system capacity, and can be easily scaled-up elsewhere.

Host Organisation

Institution Country
Noguchi Memorial Institute for Medical Research, University of Ghana Ghana

Study Design

Phase 4, cluster randomised community based, open label trial

Students Supervised

Type Name Title University Start Date End Date
MPhil Frances McCarthy Evaluation of three diagnostic tests for monitoring of lymphatic filariasis elimination in Ahanta West, Ellembelle and Nzema East districts, Western Region, Ghana University of Ghana 2017 2018

Publications

Ahorlu CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health 18:238. https://doi.org/10.1186/s12889-018-5157-7
de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA. Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial. Trials 18: 448. DOI: 10.1186/s13063-017-2196-9

Send a Message