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Associate Professor Dziedzom Komi de Souza

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-04-01
End Date 2020-03-01
Project Code TMA2015CDF976
Status Active

Title

Cluster randomized community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations

Objectives

• To quantify the impact of twice yearly versus yearly community treatment (treatment strategies and • delivery systems) in reducing parasitological and entomological LF transmission indices in hotspot areas • Assess the impact of the treatment on other helminth infections • To evaluate the costs and cost-effectiveness of twice yearly treatment in reducing disease transmission. • To assess the extent to which the twice-yearly treatment is acceptable to the community and feasible, given the health system capacity, and can be easily scaled-up elsewhere.

Host Organisation

Institution Country
Noguchi Memorial Institute for Medical Research, University of Ghana Ghana

Study Design

Phase 4, cluster randomised community based, open label trial

Students Supervised

Type Name Title University Start Date End Date
MPhil Frances McCarthy Evaluation of three diagnostic tests for monitoring of lymphatic filariasis elimination in Ahanta West, Ellembelle and Nzema East districts, Western Region, Ghana University of Ghana 2017 2018

Publications

Ahorlu CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health 18:238. https://doi.org/10.1186/s12889-018-5157-7
de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA. Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial. Trials 18: 448. DOI: 10.1186/s13063-017-2196-9
de Souza DK, Gass K, Otchere J, Htet YM, Asiedu O, Marfo B, Biritwum N-K, Boakye DA, Ahorlu CS (2020). Review of MDA registers for Lymphatic Filariasis: Findings, and potential uses in addressing the endgame elimination challenges. PLoS Negl Trop Dis 14(5): e0008306. https://doi.org/10.1371/journal.pntd.0008306
de Souza DK, Otchere J, Ahorlu CS, Adu-Amankwah S, Larbi IA, Dumashie E, McCarthy FA, King SA, Otoo S, Osabutey D, Osei JHN, Sedzro KM, Asiedu O, Dadzie SK, Ayi I, Marfo B, Biritwum N-K, Boakye DA (2018). Low Microfilaremia Levels in Three Districts in Coastal Ghana with at Least 16 Years of Mass Drug Administration and Persistent Transmission of Lymphatic Filariasis. Trop Med Infect Dis. 3:105. https://doi.org/10.3390/tropicalmed3040105
Agbozo EY, Dumashie E, Boakye DA, de Souza DK (2018). Effects of lyophilization and storage temperature on Wuchereria bancrofti antigen sensitivity and stability. BMC Research Notes 11: 454. https://doi.org/10.1186/s13104-018-3586-0

Current Organisation

Noguchi Memorial Institute for Medical Research, University of Ghana

Current Job Title

Associate Professor of Parasitiology

Students Supervised

Type Name Title University Start Date End Date

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
Kwame Nkrumah University of Science and Technology, Ghana PhD (Biological Sciences - Theoretical and Applied Biology)
University of Ghana, Ghana BSc Zoology

Areas Of Specialisation

Neglected Infectious Diseases (NID)

Grants

Improving xenomonitoring for assessing Anopheles-transmitted filariasis after several rounds of MDA to interrupt Lymphatic Filariasis transmission in Africa
Grant Code:
200076/Z/15/Z
Source of funding:
Wellcome Trust
Amount:
85690
Role:
Researcher
Start Date:
2016-09-01
End Date:
2018-08-31
Understanding the home as a source of infection of AMR bacteria carried by dust by exploring hygiene practices in different home environments in Ghana
Grant Code:
Source of funding:
Arts and Humanities Research Council
Amount:
250442
Role:
Researcher
Start Date:
2017-11-01
End Date:
2019-10-31
Strategies for the ENdgame: Targeting Infections among Non-compliants in the Elimination of Lymphatic filariasis (SENTINEL)
Grant Code:
Source of funding:
Taskforce for Global Health
Amount:
203276
Role:
Principal Investigator
Start Date:
2019-01-01
End Date:
2022-01-01
Strategies for the ENdgame: Targeting Infections among Non-treated in the Elimination of Lymphatic filariasis (SENTINEL) – Phase II
Grant Code:
Source of funding:
Taskforce for Global Health
Amount:
214130
Role:
Principal Investigator
Start Date:
2022-01-01
End Date:
2023-01-01
A Buruli ulcer mycolactone (BU-MYCOLAC) rapid diagnostic test to enhance early diagnosis and treatment.
Grant Code:
Source of funding:
Global Health Innovative Technology
Amount:
1800000
Role:
Principal Investigator
Start Date:
2021-01-01
End Date:
2024-01-01

Publications

Implications of WHO COVID-19 interim guideline 2020.5 on the comprehensive care for infected persons in Africa Before, during and after clinical management of cases
Authors:
Date:
2022-01-01
Journal:
Scientific African
Content:
Molecular xenomonitoring for post-validation surveillance of Lymphatic Filariasis in Togo: no evidence for active transmission.
Authors:
Dorkenoo MA, de Souza DK, Apetogbo Y, Oboussoumi K, Yehadji D, Tchalim M, Etassoli S, Koudou B, Ketoh GK, Sodahlon Y, Bockarie MJ, Boakye DA , Dorkenoo MA, de Souza DK, Apetogbo Y, Oboussoumi K, Yehadji D, Tchalim M, Etassoli S, Koudou B, Ketoh GK, Sodahlon Y, Bockarie MJ, Boakye DA. Molecular xenomonitoring for post-validation surveillance of Lymphatic Filariasis in Togo: no evidence for active transmission. Parasites and Vectors 11:52 DOI 10.1186/s13071-017-2611-9
Date:
2018-01-25
Journal:
Parasites and Vectors
Content:
Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial.
Authors:
de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA , de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA. Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial.Trials 18: 448. DOI: 10.1186/s13063-017-2196-9
Date:
2017-08-01
Journal:
Trials
Content:
COVID-19 related perception among some community members and frontline healthcare providers for NTD control in Ghana. BMC Infectious Diseases 22:106.
Authors:
Date:
2022-01-31
Journal:
BMC Infectious Diseases
Content:
Assessing Anopheles vector species diversity and transmission of malaria in four health districts along the borders of Côte d’Ivoire
Authors:
Date:
2021-11-01
Journal:
Malaria Journal
Content:
Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey
Authors:
Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. , Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey. PLoS Negl Trop Dis 11(12): e0006099. https://doi.org/10.1371/journal.pntd.0006099
Date:
2017-12-01
Journal:
PLOS Neglected Tropical Diseases
Content:
Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment.
Authors:
Ahorlu, CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK , Ahorlu, CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health 18:238. https://doi.org/10.1186/s12889-018-5157-7
Date:
2018-02-12
Journal:
BMC Public Health
Content:
Elimination of lymphatic filariasis in West African cities: is implementation of mass drug administration a necessity to reach this goal?
Authors:
Koudou BG, de Souza DK, N-K Biritwum, R Bougma, M Aboulaye, E Elhassan, S Bush, DH Molyneux , Koudou BG, de Souza DK, N-K Biritwum, R Bougma, M Aboulaye, E Elhassan, S Bush, DH Molyneux. Elimination of lymphatic filariasis in West African cities: is implementation of mass drug administration a necessity to reach this goal? Lancet Infect Dis 1473-3099(18):30069-0. http://dx.doi.org/10.1016/S1473-3099(18)30069-0
Date:
2018-02-02
Journal:
Lancet Infectious Diseases
Content:
Is mass drug administration against lymphatic filariasis required in urban settings? The experience in Kano, Nigeria.
Authors:
Pam DD, de Souza DK, Walker S., Opoku M, Sanda S, Nazaradeen I, Anagbogu IN, Okoronkwo C, Davies E, Elhassan E, Molyneux D, Bockarie MJ, Koudou BG , Pam DD, de Souza DK, Walker S., Opoku M, Sanda S, Nazaradeen I, Anagbogu IN, Okoronkwo C, Davies E, Elhassan E, Molyneux D, Bockarie MJ, Koudou BG. Is mass drug administration against lymphatic filariasis required in urban settings? The experience in Kano, Nigeria. PLoS Negl Trop Dis 11(10): e0006004. https://doi.org/10.1371/journal.pntd.0006004
Date:
2017-09-01
Journal:
PLOS Neglected Tropical Diseases
Content:
Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey
Authors:
Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. , Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey. PLoS Negl Trop Dis 11(12): e0006099. https://doi.org/10.1371/journal.pntd.0006099
Date:
2017-12-01
Journal:
PLOS Neglected Tropical Diseases
Content:

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