EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-04-01
End Date 2020-03-01
Project Code TMA2015CDF976
Status Active

Title

Cluster randomized community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations

Objectives

• To quantify the impact of twice yearly versus yearly community treatment (treatment strategies and • delivery systems) in reducing parasitological and entomological LF transmission indices in hotspot areas • Assess the impact of the treatment on other helminth infections • To evaluate the costs and cost-effectiveness of twice yearly treatment in reducing disease transmission. • To assess the extent to which the twice-yearly treatment is acceptable to the community and feasible, given the health system capacity, and can be easily scaled-up elsewhere.

Host Organisation

Institution Country
Noguchi Memorial Institute for Medical Research, University of Ghana Ghana

Study Design

Phase 4, cluster randomised community based, open label trial

Students Supervised

Type Name Title University Start Date End Date
MPhil Frances McCarthy Evaluation of three diagnostic tests for monitoring of lymphatic filariasis elimination in Ahanta West, Ellembelle and Nzema East districts, Western Region, Ghana University of Ghana 2017 2018

Publications

Ahorlu CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health 18:238. https://doi.org/10.1186/s12889-018-5157-7
de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA. Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial. Trials 18: 448. DOI: 10.1186/s13063-017-2196-9

Current Organisation

Noguchi Memorial Institute for Medical Research, University of Ghana

Current Job Title

Senior Research Fellow

Education

Institution Degree Year
Kwame Nkrumah University of Science and Technology, Ghana PhD (Biological Sciences - Theoretical and Applied Biology)
University of Ghana, Ghana BSc Zoology

Areas Of Specialisation

Neglected Infectious Diseases (NID)

Grants

Grant Code:
200076/Z/15/Z
Source of funding:
Wellcome Trust
Amount:
85690
Role:
Researcher
Start Date:
2016-09-01
End Date:
2018-08-31
Grant Code:
Source of funding:
Arts and Humanities Research Council
Amount:
250442
Role:
Researcher
Start Date:
2017-11-01
End Date:
2019-10-31

Publications

Authors:
Dorkenoo MA, de Souza DK, Apetogbo Y, Oboussoumi K, Yehadji D, Tchalim M, Etassoli S, Koudou B, Ketoh GK, Sodahlon Y, Bockarie MJ, Boakye DA , Dorkenoo MA, de Souza DK, Apetogbo Y, Oboussoumi K, Yehadji D, Tchalim M, Etassoli S, Koudou B, Ketoh GK, Sodahlon Y, Bockarie MJ, Boakye DA. Molecular xenomonitoring for post-validation surveillance of Lymphatic Filariasis in Togo: no evidence for active transmission. Parasites and Vectors 11:52 DOI 10.1186/s13071-017-2611-9
Date:
2018-01-25
Journal:
Parasites and Vectors
Content:
Identifiers:
Authors:
de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA , de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum, Boakye DA. Community-based trial of annual versus biannual single-dose Ivermectin plus Albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomized controlled trial.Trials 18: 448. DOI: 10.1186/s13063-017-2196-9
Date:
2017-08-01
Journal:
Trials
Content:
Identifiers:
Authors:
Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. , Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey. PLoS Negl Trop Dis 11(12): e0006099. https://doi.org/10.1371/journal.pntd.0006099
Date:
2017-12-01
Journal:
PLOS Neglected Tropical Diseases
Content:
Identifiers:
Authors:
Ahorlu, CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK , Ahorlu, CS, Koka E, Adu-Amankwah S, Otchere J, de Souza DK. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health 18:238. https://doi.org/10.1186/s12889-018-5157-7
Date:
2018-02-12
Journal:
BMC Public Health
Content:
Identifiers:
Authors:
Koudou BG, de Souza DK, N-K Biritwum, R Bougma, M Aboulaye, E Elhassan, S Bush, DH Molyneux , Koudou BG, de Souza DK, N-K Biritwum, R Bougma, M Aboulaye, E Elhassan, S Bush, DH Molyneux. Elimination of lymphatic filariasis in West African cities: is implementation of mass drug administration a necessity to reach this goal? Lancet Infect Dis 1473-3099(18):30069-0. http://dx.doi.org/10.1016/S1473-3099(18)30069-0
Date:
2018-02-02
Journal:
Lancet Infectious Diseases
Content:
Identifiers:
Authors:
Pam DD, de Souza DK, Walker S., Opoku M, Sanda S, Nazaradeen I, Anagbogu IN, Okoronkwo C, Davies E, Elhassan E, Molyneux D, Bockarie MJ, Koudou BG , Pam DD, de Souza DK, Walker S., Opoku M, Sanda S, Nazaradeen I, Anagbogu IN, Okoronkwo C, Davies E, Elhassan E, Molyneux D, Bockarie MJ, Koudou BG. Is mass drug administration against lymphatic filariasis required in urban settings? The experience in Kano, Nigeria. PLoS Negl Trop Dis 11(10): e0006004. https://doi.org/10.1371/journal.pntd.0006004
Date:
2017-09-01
Journal:
PLOS Neglected Tropical Diseases
Content:
Identifiers:
Authors:
Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. , Debrah O, Mensah EO, Senyonjo L, de Souza DK, Hervie TE, Agyemang D, Bakajika D, Marfo B, Ahorsu F, Wanye S, Bailey R, Koroma JB, Aboe A, N-K Biritwum. Elimination of trachoma as a public health problem in Ghana: providing evidence through a pre-validation survey. PLoS Negl Trop Dis 11(12): e0006099. https://doi.org/10.1371/journal.pntd.0006099
Date:
2017-12-01
Journal:
PLOS Neglected Tropical Diseases
Content:
Identifiers:

Send a Message