| Call |
Senior Fellowship (SF) |
| Programme |
EDCTP1
|
| Start Date |
2012-11-01
|
| End Date |
2015-05-29
|
| Project Code |
TA.2011.40200.062 |
| Status |
Completed
|
Title
Baseline Study of Epidemiological and Sociological aspects of Malaria in
the four Natural Regions of Guinea
Objectives
The aim of this study was to characterise at the national level malaria
epidemiological patterns and malaria indicators in
children aged between six months and 10 years, depending on the season
for two consecutive years.
The objectives were:
1. Estimate malaria infection prevalence and disease prevalence in
children aged between 6 months and 10 years in Guinea in dry
and raining seasons
2. Evaluate haemoglobin levels in children aged between 6 months
and 10 years in Guinea
3. Measure the genotype of the main resistance genes namely Pfcrt
(P. falciparum chloroquine resistance transport), pfmdr1 (P.
falciparum multidrug resistance 1); pfatp6
4. Determine impregnated or treated mosquito nets use in Guinea
5. Assess knowledge, attitudes and practices of mothers and legal
parents of children aged between 6 months 10 years towards
malaria in the first year of study and during the high malaria
transmission season
6. Estimate entomological parameters of malaria transmission for
two consecutive years and seasons withinthe four natural regions
of Guinea.
Host Organisation
| Institution |
Country |
| Centre National de Formation et de Recherche en Santé Rurale (CNFRSR) Jean SENECAL de Mafèrinyah |
Guinea |
Participants
| Name |
Institution |
Country |
| Alexandre Delamou |
Centre National de Formation et de Recherche en Santé Rurale (CNFRSR) Jean SENECAL de Mafèrinyah |
Guinea |
| Mohamed Diaby |
University of General Lansana Conte |
Guinea |
| Abdoulaye Djimde |
Malaria Research & Training Center |
Mali |
| Abdoulaye Doumbouyah |
Centre National de Formation et de Recherche en Santé Rurale (CNFRSR) Jean SENECAL de Mafèrinyah |
Guinea |
| Issaka Sagara |
University of Bamako, |
Mali |
Study Design
Observational, cross-sectional survey
Sites
| The study was conducted in the four natural regions of Guinea: Lower Guinea, Middle Guinea, Upper Guinea and Forest Guinea |
Results & Outcomes
Three cross-sectional surveys were conducted in 4 regions: Lower Guinea,
Middle Guinea, Upper Guinea and Forest Guinea.
The prevalence of malaria as determined by thick smear during the first
cross-sectional survey was 18.5% in Guinea with variations across natural
regions. The lowest prevalence was found in the Upper Guinea region
(11.4%) while the Forest Guinea region had the highest prevalence
(35.7%).
Project Porftolio Page 390 of 622
Two Anopheles species were found in the country with regional disparities:
Anopheles gambiae (molecular form S, 84%) and Anopheles coluzzii
(molecular form M, 16%). In terms of the distribution and frequency of
alleles L1014F kdr mutation, 77%, 0%, 27%, 39% were found in Anopheles
coluzzii respectively in Lower Guinea, Middle Guinea, Upper Guinea and
Forest Guinea. The distributions and frequency of the kdr mutation for
Anopheles gambiae was 89%, 95%, 37%, and 45% respectively in Lower
Guinea, Middle Guinea, Upper Guinea and Forest Guinea. Overall 18% of
the anophelines were observed to be infected by PCR.
