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Dr Barbara Castelnuovo

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-04-01
End Date 2024-03-31
Project Code TMA2017GSF-1936
Status Active

Title

EDCTP-GSK fellowship: Diagnosis and treatment of non-communicable diseases and geriatric syndromes in the HIV aging population in sub-Saharan Africa (Geriatric HIV cohort Africa)

Objectives

Specific Aim 1. To establish a cohort of aging patients ≥60 years (Geriatric cohort) in order to capture NCD endpoints and their risk factors: hypertension, cardio vascular disease (annual ECG screening), respiratory disease (peak flow meter screening and spirometry), renal disease (proteinuria and creatinine clearance), cancers (complete skin evaluation, pap smear, faecal occult blood, breast exam) will all be added to other standard of care procedures in place. Specific Aim 2. In the Geriatric cohort we propose to measure physical function using the Short Performance Physical Battery, muscle strength, (Gait speed and assessment of grip strength with handheld dynamometry), frailty phenotype, and history of falls. The tools that were developed and submitted in Year one (paper based), were developed as e-forms using RedCap and are currently used to assess the participants. Specific Aim 3. To form a group of established clinicians and researchers in the area of HIV and various NDCs with interest in HIV and NCDs and HIV and geriatric medicine. This group will be initially advised by international mentors. Aim 3 will also support 2 master and 1 PhD students in the areas of HIV, NCDs and aging.

Host Organisation

Institution Country
Infectious Diseases Institute Uganda

Participants

Name Institution Country
Castelnuovo Barbara Infectious Diseases Institute

Study Design

Observational prospective cohort

Sites

Infectious Diseases Institute

Phd Study

Title University Start Date End Date
PREVALENCE, CLINICAL AND IMMUNOLOGICAL PREDICTORS AND OUTCOMES OF FRAILTY AMONG OLDER ADULTS WITH HIV IN KAMPALA Makerere University

Students Supervised

Type Name Title University Start Date End Date
PhD Phobe Mbabazi Dr Makerere University 2020 2023
Master in Immunology Gideon Nansubuga Dr Makerere University 2021 2023
Master in Internal medicine Judith Amutuhaire Makerere University 2022 2021

Current Organisation

Infectious Diseases Institute

Current Job Title

Head of Department

Students Supervised

Type Name Title University Start Date End Date
PhD Mbabazi Phoebe Makerere University 2020

Memberships

Role Committee/board Start Date End Date
Editor in Chief AIDS Research and Treatment 2021

Education

Institution Degree Year
University of Antwerp, Belgium PhD 2019-05-08

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Grants

FRAGING
Grant Code:
Supplement to 5 UO1 AI 069911-16
Source of funding:
NIH
Amount:
40000
Role:
Principal Investigator
Start Date:
2022-01-01
End Date:
2023-01-01
Prevalence, Clinical and Immunological Predictors of Frailty Among Older Adults with HIV in Kampala
Grant Code:
CFAR UoC
Source of funding:
NIH
Amount:
32400
Role:
Supervisor
Start Date:
2022-01-01
End Date:
2024-01-01

Publications

Implementing routine physical function screening among elderly HIV-positive patients in Uganda.
Authors:
Date:
2019-12-17
Journal:
AIDS care
Content:
We conducted a cross-sectional study to describe routine physical function assessment for HIV-infected adults aged ≥60 years attending a large urban HIV clinic in Kampala, Uganda. Assessed demographic and clinical factors associated with low physical function in the population, generalized linear regression model was used to estimate factors associated with low physical function. Of the 93 elderly patients that underwent the Short Physical Performance Battery (SPPB) assessment, 43/93 (44.1%) scored 1-8 points at the SPPB evaluation and were categorized as low function, 45/93 (48.4%) scored 9-11 points and were categorized as moderate function and 7/93 (7.5%) scored 12 points and were categorized as high (normal) function. Women (adjusted risk ratio (ARR) 2.57; 95% confidence interval (CI): 1.54-4.29, p = 0.000) had increased risk of low physical function compared to men. A one-year increase in age (ARR = 1.09; CI: 1.03-1.15, p = 0.004) and being overweight (BMI > 25.0, ARR = 1.96; CI: 1.89-3.24, p = 0.008) also carried an increased risk of low physical function status. A higher number 13/41(32%) of falls was recorded in female than among male 3/53(5.8%) patients (p = 0.001). The SPPB assessment is a starting point for clinicians to comprehensively evaluate and consider the management of physical function limitation among older HIV-positive patients.
Antiretroviral concentration measurements as an additional tool to manage virologic failure in resource limited settings: a case control study.
Authors:
Buzibye A , author
Musaazi J , author
von Braun A , author
Nanzigu S , author
Sekaggya-Wiltshire C , author
Kambugu A , author
Fehr J , author
Lamorde M , author
Gutteck U , author
Muller D , author
Sowinski S , author
Reynolds SJ , author
Castelnuovo B , author
Date:
2019-12-01
Journal:
AIDS research and therapy
Content:
Increasing retention of HIV positive pregnant and breastfeeding mothers on option-b plus by upgrading and providing full time HIV services at a lower health facility in rural Uganda.
Authors:
Masereka EM , author
Ngabirano TD , author
Osingada CP , author
Wiltshire CS , author
Castelnuovo B , author
Kiragga AN , author
Date:
2019-07-01
Journal:
BMC public health
Content:
Patient experiences of switching from Efavirenz- to Dolutegravir-based antiretroviral therapy: a qualitative study in Uganda.
Authors:
Twimukye A
Date:
2022-11-01
Journal:
BMC Infect Dis
Content:
Factors associated with uptake of contraceptives among HIV positive women on dolutegravir based anti-retroviral treatment-a cross sectional survey in urban Uganda.
Authors:
Mbabazi L
Date:
2022-06-27
Journal:
BMC Womens Health.
Content:
Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA).
Authors:
Yotebieng M , author
Brazier E , author
Addison D , author
Kimmel AD , author
Cornell M , author
Keiser O , author
Parcesepe AM , author
Onovo A , author
Lancaster KE , author
Castelnuovo B , author
Murnane PM , author
Cohen CR , author
IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group , author
Date:
2019-01-01
Journal:
Journal of the International AIDS Society
Content:
Retention of HIV infected pregnant and breastfeeding women on option B+ in Gomba District, Uganda: a retrospective cohort study.
Authors:
Kiwanuka G , author
Kiwanuka N , author
Muneza F , author
Nabirye J , author
Oporia F , author
Odikro MA , author
Castelnuovo B , author
Wanyenze RK , author
Date:
2018-10-01
Journal:
BMC infectious diseases
Content:
The Influence of Pharmacogenetic Variants in HIV/Tuberculosis Coinfected Patients in Uganda in the SOUTH Study.
Authors:
Calcagno A , author
Cusato J , author
Sekaggya-Wiltshire C , author
von Braun A , author
Motta I , author
Turyasingura G , author
Castelnuovo B , author
Fehr J , author
Di Perri G , author
Lamorde M , author
Date:
2019-03-01
Journal:
Clinical pharmacology and therapeutics
Content:
Delayed Sputum Culture Conversion in Tuberculosis-Human Immunodeficiency Virus-Coinfected Patients With Low Isoniazid and Rifampicin Concentrations.
Authors:
Sekaggya-Wiltshire C , author
von Braun A , author
Lamorde M , author
Ledergerber B , author
Buzibye A , author
Henning L , author
Musaazi J , author
Gutteck U , author
Denti P , author
de Kock M , author
Jetter A , author
Fehr JS , author
Date:
2018-08-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?
Authors:
Kiragga AN , author
Mubiru F , author
Kambugu AD , author
Kamya MR , author
Castelnuovo B , author
Date:
2019-01-01
Journal:
BMC infectious diseases
Content:
Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda: a cross-sectional survey.
Authors:
Muhindo R , author
Castelnuovo B , author
Mujugira A , author
Parkes-Ratanshi R , author
Sewankambo NK , author
Kiguli J , author
Tumwesigye NM , author
Nakku-Joloba E , author
Date:
2019-09-01
Journal:
AIDS research and therapy
Content:
Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics.
Authors:
Sarfo FS , author
Castelnuovo B , author
Fanti I , author
Feldt T , author
Incardona F , author
Kaiser R , author
Lwanga I , author
Marrone G , author
Sonnerborg A , author
Tufa TB , author
Zazzi M , author
De Luca A , author
Date:
2019-03-01
Journal:
The Journal of infection
Content:
Can COVID-19 changes reduce stigma in African HIV clinics?
Authors:
Lofgren SM
Date:
2022-07-22
Journal:
Lancet HIV.
Content:
Incidence rate of sexually transmitted infections among HIV infected patients on long-term ART in an urban and a rural clinic in Uganda.
Authors:
Okoboi S , author
Castelnuovo B , author
Moore DM , author
Musaazi J , author
Kambugu A , author
Birungi J , author
Nanfuka M , author
Van Rie A , author
Date:
2019-01-01
Journal:
BMC public health
Content:
Virological Outcome of Patients With HIV Drug Resistance Attending an Urban Outpatient Clinic in Uganda: A Need for Structured Adherence Counseling and Third-Line Treatment Options.
Authors:
Baumann A , author
Musaazi J , author
Kambugu A , author
Kälin M , author
Weissberg D , author
Ssemwanga D , author
Fehr J , author
Castelnuovo B , author
Sekaggya-Wiltshire C , author
von Braun A , author
Date:
2019-04-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
High efavirenz serum concentrations in TB/HIV-coinfected Ugandan adults with a CYP2B6 516 TT genotype on anti-TB treatment.
Authors:
von Braun A , author
Castelnuovo B , author
Ledergerber B , author
Cusato J , author
Buzibye A , author
Kambugu A , author
Fehr J , author
Calcagno A , author
Lamorde M , author
Sekaggya-Wiltshire C , author
Date:
2019-01-01
Journal:
The Journal of antimicrobial chemotherapy
Content:
A comparative study of logistic regression based machine learning techniques for prediction of early virological suppression in antiretroviral initiating HIV patients.
Authors:
Bisaso KR , author
Karungi SA , author
Kiragga A , author
Mukonzo JK , author
Castelnuovo B , author
Date:
2018-09-01
Journal:
BMC medical informatics and decision making
Content:
Reasons for first line ART modification over the years during the ART scale up in Uganda.
Authors:
Castelnuovo B , author
Mubiru F , author
Kalule I , author
Kiragga A , author
Date:
2019-10-01
Journal:
AIDS research and therapy
Content:
Patient experiences of switching from Efavirenz- to Dolutegravir-based antiretroviral therapy: a qualitative study in Uganda.
Authors:
Twimukye A
Date:
2022-11-01
Journal:
BMC Infect Dis
Content:
Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland.
Authors:
Bachmann N , author
von Braun A , author
Labhardt ND , author
Kadelka C , author
Günthard HF , author
Sekaggya-Wiltshire C , author
Castelnuovo B , author
Kambugu A , author
Lejone TI , author
Böni J , author
Yerly S , author
Perreau M , author
Swiss HIV Cohort Study , author
Date:
2019-02-01
Journal:
The Journal of antimicrobial chemotherapy
Content:
Implementation of "Treat-all" at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey.
Authors:
Brazier E , author
Maruri F , author
Duda SN , author
Tymejczyk O , author
Wester CW , author
Somi G , author
Ross J , author
Freeman A , author
Cornell M , author
Poda A , author
Musick BS , author
Zhang F , author
Althoff KN , author
Mugglin C , author
IeDEA Consortium , author
Date:
2019-07-01
Journal:
Journal of the International AIDS Society
Content:
Risky sexual behavior among patients on long-term antiretroviral therapy: a prospective cohort study in urban and rural Uganda.
Authors:
Okoboi S , author
Castelnuovo B , author
Moore DM , author
Musaazi J , author
Kambugu A , author
Birungi J , author
Kaleebu P , author
Nanfuka M , author
Kamya MR , author
Van Rie A , author
Date:
2018-10-01
Journal:
AIDS research and therapy
Content:
HIV-1 Drug Resistance Among Ugandan Adults Attending an Urban Out-Patient Clinic.
Authors:
von Braun A , author
Sekaggya-Wiltshire C , author
Bachmann N , author
Ssemwanga D , author
Scherrer AU , author
Nanyonjo M , author
Kapaata A , author
Kaleebu P , author
Günthard HF , author
Castelnuovo B , author
Fehr J , author
Kambugu A , author
Date:
2018-08-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
Bending the Arc towards Equitable Partnerships in Global Health and Applied Training.
Authors:
Martin NA , author
Kalbarczyk A , author
Nagourney E , author
Reich A , author
Hansoti B , author
Kambugu A , author
Quinn TC , author
Manabe YC , author
Castelnuovo B , author
Date:
2019-11-01
Journal:
Annals of global health
Content:
An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir.
Authors:
Laker EAO , author
Nabaggala MS , author
Kaimal A , author
Nalwanga D , author
Castelnuovo B , author
Musubire A , author
Kiragga A , author
Lamorde M , author
Ratanshi RP , author
Date:
2019-03-01
Journal:
BMC infectious diseases
Content:
Acceptability, perceived reliability and challenges associated with distributing HIV self-test kits to young MSM in Uganda: a qualitative study.
Authors:
Okoboi S , author
Twimukye A , author
Lazarus O , author
Castelnuovo B , author
Agaba C , author
Immaculate M , author
Nanfuka M , author
Kambugu A , author
King R , author
Date:
2019-03-01
Journal:
Journal of the International AIDS Society
Content:
Researchers experience of using the regulatory affairs information system (RAIS) in strengthening research compliance in a large research program: A case study of the Infectious Diseases Institute (IDI) in Uganda.
Authors:
Nabukenya S
Date:
2022-07-09
Journal:
JAMIA Open. 2022 Jul 14;5(3):ooac059. doi: 10.1093/jamiaopen/ooac059. eCollection 2022 Oct.
Content:
Ten years of antiretroviral therapy: Incidences, patterns and risk factors of opportunistic infections in an urban Ugandan cohort.
Authors:
Weissberg D , author
Mubiru F , author
Kambugu A , author
Fehr J , author
Kiragga A , author
von Braun A , author
Baumann A , author
Kaelin M , author
Sekaggya-Wiltshire C , author
Kamya M , author
Castelnuovo B , author
Date:
2018-11-01
Journal:
PloS one
Content:
Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
Authors:
Sekaggya-Wiltshire C , author
Chirehwa M , author
Musaazi J , author
von Braun A , author
Buzibye A , author
Muller D , author
Gutteck U , author
Motta I , author
Calcagno A , author
Fehr JS , author
Kambugu A , author
Castelnuovo B , author
Denti P , author
Date:
2019-05-01
Journal:
Antimicrobial agents and chemotherapy
Content:
Effect of the COVID-19 pandemic restrictions on outcomes of HIV care among adults in Uganda Jonathan Izudi
Authors:
Izudi J
Date:
2022-09-01
Journal:
Medicine (Baltimore)
Content:
Sustained positive impact on tuberculosis treatment outcomes of TB-HIV integrated care in Uganda.
Authors:
Musaazi J , author
Sekaggya-Wiltshire C , author
Kiragga AN , author
Kalule I , author
Reynolds SJ , author
Manabe YC , author
Castelnuovo B , author
Date:
2019-04-01
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Content:

Projects

East African IeDEA Regional Consortium
Fellow:
Barbara Castelnuovo
Collaborators:
Name Country Institution
Wools-Kaloustian, Yiannoutsos, Semeere Uganda Infectious Diseases Institute
Objectives:
The IeDEA Cohort Consortium collaborates to collect and define key variables, harmonize data, and implement methodology to effectively pool data as a cost-effective means of generating large data sets to address the high priority research questions and streamline HIV/AIDS research.
Sites:
Multisite East Africa
Study Design:
Observational
Subjects:
NA
Outcomes:
Observational
Start Date:
2020-05-01
End Date:
2026-05-01
H2A
Fellow:
Barbara Castelnuovo
Collaborators:
Name Country Institution
OC Uganda CAMA
Objectives:
The goal of this study is to solidify the clinical and translational research infrastructure for investigation of I-ICC in Uganda while defining HCC risk factors and contrasting the etiology of HIV-associated I-ICC compared to non-HIV HCC. The study will also characterize pathways of HIV-accelerated hepatocarcinogenesis in contrast to HIV-accelerated liver fibrosis.This scope of work (SOW) includes activities proposed for Infectious Diseases Institute, Kampala, Uganda.
Sites:
Infectious Diseases institute Lacor Hospital
Study Design:
observational
Subjects:
2000
Outcomes:
liver cancer
Start Date:
2020-09-01
End Date:
2025-08-31
HIV and co-infections
Fellow:
Barbara Castelnuovo
Collaborators:
Name Country Institution
Castelnuovo/Kambugu/Manabe Uganda Infectious Diseases Institute
Objectives:
The proposed training program for the Infectious Diseases Institute (IDI) in Uganda will train post-doctoral Fellows, PhD, and Masters Students who will be mentored by a deep pool of dedicated and experienced local mentors who have previously engaged in funded, published research in HIV and co-infections. International faculty will support the Ugandan mentors and scholars for selected area of research like laboratory-based research.
Sites:
Infectious Disease Institute
Study Design:
Capacity building for research
Subjects:
NA
Outcomes:
3 PhD 9 master scholars 5 post doc
Start Date:
2018-09-01
End Date:
2023-09-30

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