EDCTP Alumni Network

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All Profiles

Dr Barbara Castelnuovo

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-04-01
End Date 2024-03-31
Project Code TMA2017GSF-1936
Status Active

Title

EDCTP-GSK fellowship: Diagnosis and treatment of non-communicable diseases and geriatric syndromes in the HIV aging population in sub-Saharan Africa (Geriatric HIV cohort Africa)

Host Organisation

Institution Country
Uganda

Current Organisation

Infectious Diseases Institute

Current Job Title

Head of Department

Students Supervised

Type Name Title University Start Date End Date
PhD Mbabazi Phoebe Makerere University 2020

Memberships

Role Committee/board Start Date End Date
Editor in Chief AIDS Research and Treatment 2021

Education

Institution Degree Year
University of Antwerp, Belgium PhD 2019-05-08

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Publications

Implementing routine physical function screening among elderly HIV-positive patients in Uganda.
Authors:
Date:
2019-12-17
Journal:
AIDS care
Content:
We conducted a cross-sectional study to describe routine physical function assessment for HIV-infected adults aged ≥60 years attending a large urban HIV clinic in Kampala, Uganda. Assessed demographic and clinical factors associated with low physical function in the population, generalized linear regression model was used to estimate factors associated with low physical function. Of the 93 elderly patients that underwent the Short Physical Performance Battery (SPPB) assessment, 43/93 (44.1%) scored 1-8 points at the SPPB evaluation and were categorized as low function, 45/93 (48.4%) scored 9-11 points and were categorized as moderate function and 7/93 (7.5%) scored 12 points and were categorized as high (normal) function. Women (adjusted risk ratio (ARR) 2.57; 95% confidence interval (CI): 1.54-4.29, p = 0.000) had increased risk of low physical function compared to men. A one-year increase in age (ARR = 1.09; CI: 1.03-1.15, p = 0.004) and being overweight (BMI > 25.0, ARR = 1.96; CI: 1.89-3.24, p = 0.008) also carried an increased risk of low physical function status. A higher number 13/41(32%) of falls was recorded in female than among male 3/53(5.8%) patients (p = 0.001). The SPPB assessment is a starting point for clinicians to comprehensively evaluate and consider the management of physical function limitation among older HIV-positive patients.
Identifiers:
PMID: 31847531
DOI: 10.1080/09540121.2019.1703888
Antiretroviral concentration measurements as an additional tool to manage virologic failure in resource limited settings: a case control study.
Authors:
Buzibye A , author
Musaazi J , author
von Braun A , author
Nanzigu S , author
Sekaggya-Wiltshire C , author
Kambugu A , author
Fehr J , author
Lamorde M , author
Gutteck U , author
Muller D , author
Sowinski S , author
Reynolds SJ , author
Castelnuovo B , author
Date:
2019-12-01
Journal:
AIDS research and therapy
Content:
Identifiers:
PMID: 31810468
PMC: PMC6898957
DOI: 10.1186/s12981-019-0255-x
Increasing retention of HIV positive pregnant and breastfeeding mothers on option-b plus by upgrading and providing full time HIV services at a lower health facility in rural Uganda.
Authors:
Masereka EM , author
Ngabirano TD , author
Osingada CP , author
Wiltshire CS , author
Castelnuovo B , author
Kiragga AN , author
Date:
2019-07-01
Journal:
BMC public health
Content:
Identifiers:
PMID: 31307455
PMC: PMC6631982
DOI: 10.1186/s12889-019-7280-5
Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA).
Authors:
Yotebieng M , author
Brazier E , author
Addison D , author
Kimmel AD , author
Cornell M , author
Keiser O , author
Parcesepe AM , author
Onovo A , author
Lancaster KE , author
Castelnuovo B , author
Murnane PM , author
Cohen CR , author
IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group , author
Date:
2019-01-01
Journal:
Journal of the International AIDS Society
Content:
Identifiers:
PMID: 30657644
PMC: PMC6338103
DOI: 10.1002/jia2.25218
Retention of HIV infected pregnant and breastfeeding women on option B+ in Gomba District, Uganda: a retrospective cohort study.
Authors:
Kiwanuka G , author
Kiwanuka N , author
Muneza F , author
Nabirye J , author
Oporia F , author
Odikro MA , author
Castelnuovo B , author
Wanyenze RK , author
Date:
2018-10-01
Journal:
BMC infectious diseases
Content:
Identifiers:
PMID: 30355356
PMC: PMC6201534
DOI: 10.1186/s12879-018-3450-9
The Influence of Pharmacogenetic Variants in HIV/Tuberculosis Coinfected Patients in Uganda in the SOUTH Study.
Authors:
Calcagno A , author
Cusato J , author
Sekaggya-Wiltshire C , author
von Braun A , author
Motta I , author
Turyasingura G , author
Castelnuovo B , author
Fehr J , author
Di Perri G , author
Lamorde M , author
Date:
2019-03-01
Journal:
Clinical pharmacology and therapeutics
Content:
Identifiers:
PMID: 30779340
DOI: 10.1002/cpt.1403
Delayed Sputum Culture Conversion in Tuberculosis-Human Immunodeficiency Virus-Coinfected Patients With Low Isoniazid and Rifampicin Concentrations.
Authors:
Sekaggya-Wiltshire C , author
von Braun A , author
Lamorde M , author
Ledergerber B , author
Buzibye A , author
Henning L , author
Musaazi J , author
Gutteck U , author
Denti P , author
de Kock M , author
Jetter A , author
Fehr JS , author
Date:
2018-08-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Identifiers:
PMID: 29514175
PMC: PMC6094003
DOI: 10.1093/cid/ciy179
A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?
Authors:
Kiragga AN , author
Mubiru F , author
Kambugu AD , author
Kamya MR , author
Castelnuovo B , author
Date:
2019-01-01
Journal:
BMC infectious diseases
Content:
Identifiers:
PMID: 30665434
PMC: PMC6341568
DOI: 10.1186/s12879-019-3724-x
Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda: a cross-sectional survey.
Authors:
Muhindo R , author
Castelnuovo B , author
Mujugira A , author
Parkes-Ratanshi R , author
Sewankambo NK , author
Kiguli J , author
Tumwesigye NM , author
Nakku-Joloba E , author
Date:
2019-09-01
Journal:
AIDS research and therapy
Content:
Identifiers:
PMID: 31533749
PMC: PMC6751878
DOI: 10.1186/s12981-019-0244-0
Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics.
Authors:
Sarfo FS , author
Castelnuovo B , author
Fanti I , author
Feldt T , author
Incardona F , author
Kaiser R , author
Lwanga I , author
Marrone G , author
Sonnerborg A , author
Tufa TB , author
Zazzi M , author
De Luca A , author
Date:
2019-03-01
Journal:
The Journal of infection
Content:
Identifiers:
PMID: 30849438
DOI: 10.1016/j.jinf.2019.03.003
Incidence rate of sexually transmitted infections among HIV infected patients on long-term ART in an urban and a rural clinic in Uganda.
Authors:
Okoboi S , author
Castelnuovo B , author
Moore DM , author
Musaazi J , author
Kambugu A , author
Birungi J , author
Nanfuka M , author
Van Rie A , author
Date:
2019-01-01
Journal:
BMC public health
Content:
Identifiers:
PMID: 30658611
PMC: PMC6339266
DOI: 10.1186/s12889-019-6417-x
Virological Outcome of Patients With HIV Drug Resistance Attending an Urban Outpatient Clinic in Uganda: A Need for Structured Adherence Counseling and Third-Line Treatment Options.
Authors:
Baumann A , author
Musaazi J , author
Kambugu A , author
Kälin M , author
Weissberg D , author
Ssemwanga D , author
Fehr J , author
Castelnuovo B , author
Sekaggya-Wiltshire C , author
von Braun A , author
Date:
2019-04-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
Identifiers:
PMID: 30633041
DOI: 10.1097/qai.0000000000001943
High efavirenz serum concentrations in TB/HIV-coinfected Ugandan adults with a CYP2B6 516 TT genotype on anti-TB treatment.
Authors:
von Braun A , author
Castelnuovo B , author
Ledergerber B , author
Cusato J , author
Buzibye A , author
Kambugu A , author
Fehr J , author
Calcagno A , author
Lamorde M , author
Sekaggya-Wiltshire C , author
Date:
2019-01-01
Journal:
The Journal of antimicrobial chemotherapy
Content:
Identifiers:
PMID: 30239753
DOI: 10.1093/jac/dky379
A comparative study of logistic regression based machine learning techniques for prediction of early virological suppression in antiretroviral initiating HIV patients.
Authors:
Bisaso KR , author
Karungi SA , author
Kiragga A , author
Mukonzo JK , author
Castelnuovo B , author
Date:
2018-09-01
Journal:
BMC medical informatics and decision making
Content:
Identifiers:
PMID: 30180893
PMC: PMC6123949
DOI: 10.1186/s12911-018-0659-x
Reasons for first line ART modification over the years during the ART scale up in Uganda.
Authors:
Castelnuovo B , author
Mubiru F , author
Kalule I , author
Kiragga A , author
Date:
2019-10-01
Journal:
AIDS research and therapy
Content:
Identifiers:
PMID: 31597561
PMC: PMC6785877
DOI: 10.1186/s12981-019-0246-y
Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland.
Authors:
Bachmann N , author
von Braun A , author
Labhardt ND , author
Kadelka C , author
Günthard HF , author
Sekaggya-Wiltshire C , author
Castelnuovo B , author
Kambugu A , author
Lejone TI , author
Böni J , author
Yerly S , author
Perreau M , author
Swiss HIV Cohort Study , author
Date:
2019-02-01
Journal:
The Journal of antimicrobial chemotherapy
Content:
Identifiers:
PMID: 30476115
DOI: 10.1093/jac/dky436
Implementation of "Treat-all" at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey.
Authors:
Brazier E , author
Maruri F , author
Duda SN , author
Tymejczyk O , author
Wester CW , author
Somi G , author
Ross J , author
Freeman A , author
Cornell M , author
Poda A , author
Musick BS , author
Zhang F , author
Althoff KN , author
Mugglin C , author
IeDEA Consortium , author
Date:
2019-07-01
Journal:
Journal of the International AIDS Society
Content:
Identifiers:
PMID: 31623428
PMC: PMC6625339
DOI: 10.1002/jia2.25331
Risky sexual behavior among patients on long-term antiretroviral therapy: a prospective cohort study in urban and rural Uganda.
Authors:
Okoboi S , author
Castelnuovo B , author
Moore DM , author
Musaazi J , author
Kambugu A , author
Birungi J , author
Kaleebu P , author
Nanfuka M , author
Kamya MR , author
Van Rie A , author
Date:
2018-10-01
Journal:
AIDS research and therapy
Content:
Identifiers:
PMID: 30340608
PMC: PMC6195707
DOI: 10.1186/s12981-018-0203-1
HIV-1 Drug Resistance Among Ugandan Adults Attending an Urban Out-Patient Clinic.
Authors:
von Braun A , author
Sekaggya-Wiltshire C , author
Bachmann N , author
Ssemwanga D , author
Scherrer AU , author
Nanyonjo M , author
Kapaata A , author
Kaleebu P , author
Günthard HF , author
Castelnuovo B , author
Fehr J , author
Kambugu A , author
Date:
2018-08-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
Identifiers:
PMID: 29771783
DOI: 10.1097/qai.0000000000001717
Bending the Arc towards Equitable Partnerships in Global Health and Applied Training.
Authors:
Martin NA , author
Kalbarczyk A , author
Nagourney E , author
Reich A , author
Hansoti B , author
Kambugu A , author
Quinn TC , author
Manabe YC , author
Castelnuovo B , author
Date:
2019-11-01
Journal:
Annals of global health
Content:
Identifiers:
PMID: 31750079
PMC: PMC6838765
DOI: 10.5334/aogh.2564
An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir.
Authors:
Laker EAO , author
Nabaggala MS , author
Kaimal A , author
Nalwanga D , author
Castelnuovo B , author
Musubire A , author
Kiragga A , author
Lamorde M , author
Ratanshi RP , author
Date:
2019-03-01
Journal:
BMC infectious diseases
Content:
Identifiers:
PMID: 30909871
PMC: PMC6434787
DOI: 10.1186/s12879-019-3907-5
Acceptability, perceived reliability and challenges associated with distributing HIV self-test kits to young MSM in Uganda: a qualitative study.
Authors:
Okoboi S , author
Twimukye A , author
Lazarus O , author
Castelnuovo B , author
Agaba C , author
Immaculate M , author
Nanfuka M , author
Kambugu A , author
King R , author
Date:
2019-03-01
Journal:
Journal of the International AIDS Society
Content:
Identifiers:
PMID: 30932364
PMC: PMC6441924
DOI: 10.1002/jia2.25269
Ten years of antiretroviral therapy: Incidences, patterns and risk factors of opportunistic infections in an urban Ugandan cohort.
Authors:
Weissberg D , author
Mubiru F , author
Kambugu A , author
Fehr J , author
Kiragga A , author
von Braun A , author
Baumann A , author
Kaelin M , author
Sekaggya-Wiltshire C , author
Kamya M , author
Castelnuovo B , author
Date:
2018-11-01
Journal:
PloS one
Content:
Identifiers:
PMID: 30383836
PMC: PMC6211746
DOI: 10.1371/journal.pone.0206796
Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
Authors:
Sekaggya-Wiltshire C , author
Chirehwa M , author
Musaazi J , author
von Braun A , author
Buzibye A , author
Muller D , author
Gutteck U , author
Motta I , author
Calcagno A , author
Fehr JS , author
Kambugu A , author
Castelnuovo B , author
Denti P , author
Date:
2019-05-01
Journal:
Antimicrobial agents and chemotherapy
Content:
Identifiers:
PMID: 30910890
PMC: PMC6535538
DOI: 10.1128/AAC.02174-18
Sustained positive impact on tuberculosis treatment outcomes of TB-HIV integrated care in Uganda.
Authors:
Musaazi J , author
Sekaggya-Wiltshire C , author
Kiragga AN , author
Kalule I , author
Reynolds SJ , author
Manabe YC , author
Castelnuovo B , author
Date:
2019-04-01
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Content:
Identifiers:
PMID: 31064632
DOI: 10.5588/ijtld.18.0306

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