Dr Willliam Worodria
| Call | Senior Fellowship (SF) |
| Programme | EDCTP2 |
| Start Date | 2020-01-01 |
| End Date | 2024-12-31 |
| Project Code | TMA2018SF-2465 |
| Status | Active |
Title
Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a Pragmatic Approach (LoRTISA study)
Host Organisation
| Institution | Country |
|---|---|
| Infectious Diseases Institute Limited (IDI) | Uganda |
| Call | Senior Fellowship (SF) |
| Programme | EDCTP1 |
| Start Date | 2011-04-11 |
| End Date | 2014-04-10 |
| Project Code | TA.2010.40200.0019 |
| Status | Completed |
Title
Short- and long-term clinical and immunological outcomes of patients with HIV/TB coinfections on ART
Objectives
To study short-term effects of TB and ART treatment (the incidence, predictors and clinical characteristics of TB-IRIS, side effects of the therapy, causes of early mortality) and long term effects of ART after completing TB treatment (clinical events such as infections, late-onset IRIS, adverse effects of therapy or immunological and virological events such as changes in CD4 counts, CD4 %; viral load, viral resistance). Also to study possible factors influencing these outcomes such as adherence and factors affecting them, TB relapse and mycobacteriological factors, immunological defects and social factors that are associated with a recurrent TB episode and causes of mortality
Host Organisation
| Institution | Country |
|---|---|
| Makerere University | Uganda |
Participants
| Name | Institution | Country |
|---|---|---|
| Robert Colebunders | University of Antwerp | Belgium |
| Yukari Manabe | Makerere University | Uganda |
Study Design
A cohort study to compare the effectiveness of early versus delayed antiretroviral therapy on prevention of mortality HIV-TB co-infected patients in a programmatic setting
Sites
| The HIV-TB Clinic of the Infectious Disease Institute, Kampala, Uganda |
Phd Study
| Title | University | Start Date | End Date |
|---|---|---|---|
| The Challenges of TB-HIV in Resource-limited settings | University of Antwerp, Belgium | 2006-08-25 | 2012-01-12 |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| Masters of Medicine | Dr. Christian Roy Thomas | Dr | Makerere University | 2013 | 2014 |
Results & Outcomes
Targeted recruitment: 189 out of 280 patients were enrolled for the study. Capacity Building: 1) Dr Jabo Christian who enrolled for a Masters of Medicine in Radiology at Makerere University successfully defended his thesis in May 2014. 2) Ms Justine Nakiwala, the PhD student at the Institute of Tropical Medicine, Antwerp who was studying the role of neutrophils in the pathogenesis of TB-IRIS completed the initial stage of her data collection at this site and continued with her PhD work in South Africa.
Publications
| Worodria W, Ssempijja V, Hanrahan C, Ssegonja R, Muhofwa A, Mazapkwe D, Mayanja-Kizza H, Reynolds SJ, Colebunders R, Manabe YC. Opportunistic diseases diminish the clinical benefit of immediate antiretroviral therapy in HIV-tuberculosis co-infected adults with low CD4+ cell counts. AIDS. 2018 Sep 24;32(15):2141-2149. doi: 10.1097/QAD.0000000000001941. PMID: 30005014 |
| Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, Mayanja-Kizza H, Colebunders R, Kestens L, Wilkinson KA, Lowe DM. Neutrophil activation and enhanced release of granule products in HIV-TB immune reconstitution inflammatory syndrome. J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):221-229. doi: 10.1097/QAI.0000000000001582. |
Current Organisation
Mulago Hospital, Kampala, Uganda
Current Job Title
Senior Consultant (Internal Medicine) & Head, Division of Respiratory Medicine
Awards
| 2014 | Common Wealth Scholarship for an MSc in Epidemiology and Biostatistics (LSTMH) |
| 2015 | Post Doctoral Fellowship on TB-HIV at the Infectious Disease Institute, Kampala and Johns Hopkins University |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| Masters | John Lusiba Kafuluma | Dr | Makerere University | 2012 | 2013 |
| Masters | Jabo Christian Roy Thomas | Dr | Makerere University | 2013 | 2014 |
| Masters | : Acen Lilian Ester | Ms | Makerere University | 2013 | 2014 |
| Masters | Louisa Namata | Dr | Makerere University | 2013 | 2014 |
| Masters | Ibanda Hood Ahmed | Dr | Makerere University | 2013 | 2014 |
| Masters | Kalema Nelson | Dr | Makerere University | 2013 | 2014 |
| Masters | Katagira Winceslaus | Dr | Makerere University | 2014 | 2015 |
| Masters | Agnes Bwanika Naggirinya | Dr | Makerere University | 2015 | 2016 |
| Masters | Rachel Beyagira | Dr | Makerere University | 2015 | 2016 |
| Masters | John Mukisa | Dr | Makerere University | 2015 | 2016 |
| Masters | Musisi Emmanuel | Mr | Makerere University | 2015 | 2016 |
| Masters | Ahmed Ddungu | Dr | Makerere University | 2016 | 2017 |
| Masters | Pastan Lusiba | Ms | Makerere University | 2016 | 2017 |
| Masters | Joseph B. Baluku | Dr | Makerere University | 2017 | 2018 |
| Masters | Brenda Nakafeero | Ms | Makerere University | 2017 | 2018 |
Memberships
| Role | Committee/board | Start Date | End Date |
|---|---|---|---|
| Reviewer | African Heath Sciences | ||
| Reviewer | Antiretroviral Therapy | ||
| Reviewer | BMC Infectious Diseases | ||
| Reviewer | British Journal of Pharmaceutical Research | ||
| Reviewer | Clinical Infectious Diseases | ||
| Reviewer | Expert Review of Respiratory Medicine | ||
| Reviewer | International Journal of STD & AIDS | ||
| Reviewer | International Journal of Tuberculosis and Lung Disease | ||
| Reviewer | Journal of AIDS & Clinical Research | ||
| Reviewer | Journal of Acquired Immunodeficiency Syndrome | ||
| Reviewer | PLoS ONE | ||
| Reviewer | Scandinavian Journal of Infectious Diseases | ||
| Reviewer | The Lancet Infectious Diseases | ||
| Reviewer | The Lancet Global Health | ||
| Reviewer | Tuberculosis Research and Treatment | ||
| Reviewer | Medical Research Council | ||
| Reviewer | Wellcome Trust |
Education
| Institution | Degree | Year |
|---|---|---|
| Makerere University, Uganda | MBChB | 1994-01-24 |
| Makerere University, Uganda | Master of Medicine | 2000-10-06 |
| University of Antwerp, Belgium | PhD | 2012-01-12 |
Areas Of Specialisation
Human Immuno-deficiency Virus (HIV) Tuberculosis (TB) Lower Respiratory Tract Infections (LRTIs)
Grants
Grant Code:
R01 HL090335
Source of funding:
NIH
Amount:
781910.00
Role:
Site Principal Investigator
Start Date:
2007-09-28
End Date:
2014-12-31
Grant Code:
K23 HL094141
Source of funding:
NIH
Amount:
152446
Role:
Country Principal Investigator
Start Date:
2009-04-09
End Date:
2015-03-31
Grant Code:
MR/PO22006/1
Source of funding:
MRC
Amount:
40000
Role:
Start Date:
2018-04-01
End Date:
2019-03-31
Grant Code:
R21 AI101714
Source of funding:
NIH
Amount:
222750
Role:
Country Principal Investigator
Start Date:
2012-07-10
End Date:
2015-06-30
Grant Code:
K24 HL087713
Source of funding:
NIH
Amount:
181443
Role:
Country Principal Investigator
Start Date:
2006-09-30
End Date:
2018-12-31
Grant Code:
U01AI115642-01
Source of funding:
NIH
Amount:
719693
Role:
Researcher
Start Date:
2015-01-01
End Date:
2019-12-31
Publications
Authors:
Worodria W, Massinga-Loembe M, Mazakpwe D, Luzinda K, Menten J, Van Leth F, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R for the TB-IRIS Study Group.
, J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):32-7.
Date:
2011-09-01
Journal:
Journal of Acquired Immune Deficiency Syndrome
Content:
Authors:
Lusiba JK, Nakiyingi L, Kirenga BJ, Kiragga A, Lukande R, Nsereko M, Ssengooba W, Katamba A, Worodria W, Joloba ML, Mayanja-Kizza H.
, Lusiba JK, Nakiyingi L, Kirenga BJ, Kiragga A, Lukande R, Nsereko M, Ssengooba W, Katamba A, Worodria W, Joloba ML, Mayanja-Kizza H. Evaluation of Cepheid's Xpert MTB/RIF Test on Pleural Fluid in the Diagnosis of Pleural Tuberculosis in a High Prevalence HIV/TB Setting. PLoS One. 2014 Jul 22;9(7):e102702. doi: 10.1371/journal.pone.0102702.
Date:
2014-07-22
Journal:
PLoS One.
Content:
Authors:
Worodria W, Massinga-Loembe M, Mayanja-Kizza H, Jane Namaganda, Kambugu A, Manabe C, Kestens L, and Colebunders R.
, 58. Worodria W, Massinga-Loembe M, Mayanja-Kizza H, Jane Namaganda, Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology. 2011;758350.
Date:
2010-12-08
Journal:
Clinical and Developmental Immunology.
Content:
Authors:
Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G; for the TB-IRIS Study Group.
, Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G; for the TB-IRIS Study Group. The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome. Immunobiology. 2014 Jan;219(1):37-44.
Date:
2015-07-25
Journal:
Immunobiology
Content:
Authors:
Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L.
, Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L. Impact of Xpert MTB/RIF Testing on Tuberculosis Management and Outcomes in Hospitalized Patients in Uganda. PLoS One. 2012;7(11):e48599.
Date:
2012-11-06
Journal:
PLoS One.
Content:
Authors:
Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L.
, PLoS One. 2012;7(6):e39838
Date:
2012-06-26
Journal:
PLoS One
Content:
Authors:
Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L;
, Diagn Microbiol Infect Dis. 2012 Feb;72(2):139-43.
Date:
2012-02-01
Journal:
Diagnostic Microbiology and Infectious Disease
Content:
Authors:
Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A
, Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A. Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda. PLoS One. 2017 Aug 2;12(8):e0180122. doi: 10.1371/journal.pone.0180122. eCollection 2017.PMID: 28767658
Date:
2017-08-02
Journal:
PLoS One
Content:
Authors:
Namiiro S, Wobudeya E, Colebunders R, Worodria W.
, Namiiro S, Wobudeya E, Colebunders R, Worodria W. Molecular tests expedite the diagnosis of multidrug-resistant tuberculosis in childhood. Int J Tuberc Lung Dis. 2018 Mar 1;22(3):349-350. PMID:29471914
Date:
2018-03-01
Journal:
International Journal of Tuberculosis And Lung Disease
Content:
Authors:
Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study.
, Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study. A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda. PLoS One. 2015 May 11;10(5):e0126591. doi: 10.1371/journal.pone.0126591. eCollection 2015.
Date:
2015-05-11
Journal:
PLoS One.
Content:
Authors:
Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM.
, Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM. Detection of Mycobacterium tuberculosis Peptides in the Exosomes of Patients with Active and Latent M. tuberculosis Infection Using MRM-MS. PLoS One. 2014 Jul 31;9(7):e103811. doi: 10.1371/journal.pone.0103811. PMID:25080351
Date:
2014-07-31
Journal:
PLoS One.
Content:
Authors:
Dirix V, Schepers K, Massinga-Loembe M, Worodria W, Colebunders R, Singh M, Locht C, Kestens L, Mascart F
, Dirix V, Schepers K, Massinga-Loembe M, Worodria W, Colebunders R, Singh M, Locht C, Kestens L, Mascart F; TB-IRIS study group. Added Value of Long-Term Cytokine Release Assays to Detect Mycobacterium tuberculosis Infection in HIV-Infected Subjects in Uganda. J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):344-52. PMID: 27306506
Date:
2016-07-01
Journal:
Journal of Acquired Immune Deficiency Syndrome
Content:
Authors:
Andama AO, Boon SD, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L
, Andama AO, Boon SD, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L; on behalf of the International HIV-associated Opportunistic Pneumonias (IHOP) Study. Prevalence and Outcomes of Cryptococcal Antigenemia in HIV-seropositive Patients Hospitalized for Suspected Tuberculosis in Uganda. J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):189-94.
Date:
2013-06-01
Journal:
Journal of Acquired Immune Deficiciency Syndrome.
Content:
Authors:
Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L.
, PLoS One. 2012;7(7):e38888
Date:
2012-06-12
Journal:
PLoS One
Content:
Authors:
Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, Cobelens F, Cox H, Alland D, Perkins MD.
, Lancet. 2011 Apr 30;377(9776):1495-505.
Date:
2011-04-30
Journal:
Lancet.
Content:
Authors:
Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL.
, Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis during treatment of human tuberculosis. J Infect Dis. 2015 Sep 15;212(6):990-8. PMID: 25762787
Date:
2015-09-15
Journal:
Journal of Infectious Diseases
Content:
Authors:
Worodria W, Emily C, Andama A, Sanyu I, Byanyima P, Musisi Bblt E, Kaswabuli S, Zawedde J, Ayakaka I, Sessolo A, Lalitha R, Davis JL, Huang L.
, Worodria W, Emily C, Andama A, Sanyu I, Byanyima P, Musisi Bblt E, Kaswabuli S, Zawedde J, Ayakaka I, Sessolo A, Lalitha R, Davis JL, Huang L. Predictors of Mortality among Hospitalized Patients with Lower Respiratory Tract Infections in a High HIV Burden Setting. J Acquir Immune Defic Syndr. 2018 Sep 14. doi: 10.1097/QAI.0000000000001855. PMID: 30222660
Date:
2018-09-14
Journal:
J Acquir Immune Defic Syndr.
Content:
Authors:
Kirenga BJ, Levin J, Ayakaka I, Worodria W, Reilly N, Mumbowa F, Nabanjja H, Nyakoojo G, Fennelly K, Nakubulwa S, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Mugerwa RD, Smith PG, Ellner JJ, Jones-López EC
, Kirenga BJ, Levin J, Ayakaka I, Worodria W, Reilly N, Mumbowa F, Nabanjja H, Nyakoojo G, Fennelly K, Nakubulwa S, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Mugerwa RD, Smith PG, Ellner JJ, Jones-López EC. Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study. PLoS One. 2014 Mar 7;9(3):e90614
Date:
2014-03-07
Journal:
PLoS One
Content:
Authors:
Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L.
, Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L. HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis. PLoS One. 2016 Sep 21; 11(9):e0163153. doi: 10.1371/journal.pone.0163153. eCollection 2016.
Date:
2016-09-21
Journal:
PLoS One.
Content:
Authors:
Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, Mayanja-Kizza H, Colebunders R, Kestens L, Wilkinson KA, Lowe DM.
, Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, Mayanja-Kizza H, Colebunders R, Kestens L, Wilkinson KA, Lowe DM. Neutrophil activation and enhanced release of granule products in HIV-TB immune reconstitution inflammatory syndrome. J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):221-229. doi: 10.1097/QAI.0000000000001582.
Date:
2018-02-01
Journal:
J Acquir Immune Defic Syndr.
Content:
Authors:
Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A.
, Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A. Predictors and short-term outcomes of recurrent pulmonary tuberculosis, Uganda: a cohort study. S Afr Respir J. 2017;23(4):106-112. PMID: 29368752
Date:
2018-01-22
Journal:
South African Respiratory Journal
Content:
Authors:
Kibirige D, Mutebi E, Ssekitoleko R, Worodria W, Mayanja-Kizza H.
, Kibirige D, Mutebi E, Ssekitoleko R, Worodria W, Mayanja-Kizza H. Vitamin D deficiency among adult patients with tuberculosis: a cross sectional study from a national referral hospital in Uganda. BMC Res Notes. 2013 Jul 25;6(1):293.
Date:
2013-07-25
Journal:
BMC Res Notes
Content:
Authors:
Acen EL, Worodria W, Mulamba P, Kambugu A, Erume J.
, Acen EL, Worodria W, Mulamba P, Kambugu A, Erume J. The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients. F1000Res. 2016 Jul 29;5. pii: ISCB Comm J-1890.
Date:
2016-07-29
Journal:
F1000Research
Content:
Authors:
Nakiyingi L, Kateete DP, Ocama P, Worodria W, Sempa JB, Asiimwe BB, Katabazi FA, Katamba A, Huang L, Joloba ML, Mayanja-Kizza H.
, BMC Res Notes. 2012 Sep 5;5(1):487
Date:
2012-09-05
Journal:
. BMC Research Notes
Content:
Authors:
Miremba P, Kalyango JN, Worodria W, Mugerwa H, Nakakawa E, Asiimwe BB.
, Miremba P, Kalyango JN, Worodria W, Mugerwa H, Nakakawa E, Asiimwe BB. Performance of frontloading for smear microscopy in the diagnosis of pulmonary tuberculosis: a cross-sectional study at a referral hospital in Uganda. PLoS One. 2012;7(10):e48531.
Date:
2012-10-29
Journal:
PLoS One
Content:
Authors:
Kibirige D, Kampiire L, Atuhe D, Mwebaze R, Katagira W, Muttamba W, Nantanda R, Worodria W, Kirenga B.
, Kibirige D, Kampiire L, Atuhe D, Mwebaze R, Katagira W, Muttamba W, Nantanda R, Worodria W, Kirenga B. Access to affordable medicines and diagnostic tests for asthma and COPD in sub Saharan Africa: the Ugandan perspective. BMC Pulm Med. 2017 Dec 8;17(1):179. doi: 10.1186/s12890-017-0527-y.PMID: 29216852
Date:
2018-12-08
Journal:
BMC Pulmonary Medicine
Content:
Authors:
Kirenga BJ, Worodria W, Massinga-Loembe M, Nalwoga T, Manabe YC, Kestens L, Colebunders R, Mayanja-Kizza H.
, Kirenga BJ, Worodria W, Massinga-Loembe M, Nalwoga T, Manabe YC, Kestens L, Colebunders R, Mayanja-Kizza H. Tuberculin skin test conversion among HIV patients on antiretroviral therapy in Uganda. Int J Tuberc Lung Dis. 2013 Mar;17(3):336-41.
Date:
2013-03-01
Journal:
International Journal Against Tuberculosis And Lung Disease
Content:
Authors:
Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G; for the TB-IRIS study group
, Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G; for the TB-IRIS study group. Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS. 2013 Jul 17;27(11):1725-1734
Date:
2013-07-17
Journal:
AIDS.
Content:
Authors:
Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L
, Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L; International HIV-Associated Opportunistic Pneumonias (IHOP) Study. Serologic Responses to Recombinant Pneumocystis jirovecii Major Surface Glycoprotein among Ugandan Patients with Respiratory Symptoms. PLoS One. 2012 December 21;7(12):e51545.
Date:
2012-12-21
Journal:
PLoS One
Content:
Authors:
Walter ND, Moore CM, Kayigire XA, Dide-Agossou C, Worodria W, Huang L, Everett CK, Schoolnik GS, Nahid P, Lucian Davis J.
, Walter ND, Moore CM, Kayigire XA, Dide-Agossou C, Worodria W, Huang L, Everett CK, Schoolnik GS, Nahid P, Lucian Davis J. Does discovery of differentially culturable M tuberculosis really demand a new treatment paradigm? Longitudinal analysis of DNA clearance from sputum. BMC Infect Dis. 2018 Jul 3;18(1):293. doi: 10.1186/s12879-018-3213-7. PMID: 29970012
Date:
2018-07-03
Journal:
BMC Infectious Diseases
Content:
Authors:
Manabe YC, Worodria W, van Leth F, Mayanja-Kizza H, Traore AN, Ferro J, Pakker N, Frank M, Grobusch MP, Colebunders R, Cobelens F.
, Manabe YC, Worodria W, van Leth F, Mayanja-Kizza H, Traore AN, Ferro J, Pakker N, Frank M, Grobusch MP, Colebunders R, Cobelens F. Prevention of Early Mortality by Presumptive Tuberculosis Therapy Study: An Open Label, Randomized Controlled Trial. Am J Trop Med Hyg. 2016 Dec 7;95(6):1265-1271. PMID: 27928077
Date:
2016-12-07
Journal:
American Journal of Tropical Medicine and Hygiene
Content:
Authors:
Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L;
, Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study. Low Prevalence of Pneumocystis pneumonia (PCP) but High Prevalence of Pneumocystis dihydropteroate synthase (dhps) Gene Mutations in HIV-Infected Persons in Uganda. PLoS One. 2012 Nov 16;7(11):e49991.
Date:
2018-10-16
Journal:
PLoS One. 2012 Nov 16;7(11):e49991.
Content:
Authors:
Serugendo AN, Kirenga BJ, Hawkes M, Nakiyingi L, Worodria W, Okot-Nwang M.
, Serugendo AN, Kirenga BJ, Hawkes M, Nakiyingi L, Worodria W, Okot-Nwang M. Evaluation of asthma control using Global Initiative for Asthma criteria and the Asthma Control Test in Uganda. Int J Tuberc Lung Dis. 2014 Mar;18(3):371-6.
Date:
2014-03-01
Journal:
International Journal of Tuberculosis And Lung Disease.
Content:
Authors:
Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV.
, Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV. The Lung Microbiome of Ugandan HIV-Infected Pneumonia Patients Is Compositionally and Functionally Distinct from That of San Franciscan Patients. PLoS One. 2014 Apr 21;9(4):e95726.
Date:
2014-04-21
Journal:
PLoS One.
Content:
Authors:
Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group.
, Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group. Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. PLoS One. 2015 Jul 24;10(7):e0133924. doi: 10.1371/journal.pone.0133924.
Date:
2014-07-24
Journal:
PLoS One.
Content:
Authors:
Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L, the TB-IRIS Study Group.
, Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L, the TB-IRIS Study Group. LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients. PLoS One. 2013 Nov 28;8(11):e81856.
Date:
2013-11-28
Journal:
PLoS One.
Content:
Authors:
Conesa-Botella A, Loembé MM, Manabe YC, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Miri M, Mbabazi O, Koole O, Kestens L, Colebunders R.
, J Acquir Immune Defic Syndr. 2011 Dec 15;58(5):463-8.
Date:
2011-12-15
Journal:
Journal of Acquired Immune Deficiency Syndrome
Content:
Authors:
Huang L, Cattamanchi A, Davis JL, Boon SD, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H; on behalf of the International HIV-associated Opportunistic Pneumonias (IHOP) Study and the Lung HIV Study.
, Proc Am Thorac Soc. 2011 Jun;8(3):294-300.
Date:
2011-09-01
Journal:
Proceedings of American Thoracic Society.
Content:
Authors:
Kisembo, HN, den Boon, S, Davis, JL, Okello, R, Worodria, W, Cattamanchi, A, Huang, L, and Kawooya, MG.
, Br J Radiol. 2012 Jun;85(1014):e130-9
Date:
2012-06-01
Journal:
British Journal of Radiology
Content:
Authors:
Kibirige D, Ssekitoleko R, Mutebi E, Worodria W.
, Kibirige D, Ssekitoleko R, Mutebi E, Worodria W. Overt diabetes mellitus among newly diagnosed Ugandan tuberculosis patients: a cross sectional study. BMC Infect Dis. 2013 Mar 5; 13:122.
Date:
2013-03-01
Journal:
BMC Infectious Diseases..
Content:
Authors:
Nakiyingi L, Bwanika JM, Lukande R, Kirenga B, Mwambu TP, Worodria W, Okot-Nwang M.
, Nakiyingi L, Bwanika JM, Lukande R, Kirenga B, Mwambu TP, Worodria W, Okot-Nwang M. Destructive rib lesions in an HIV sero-negative male: an unusual presentation of tuberculosis in a high tuberculosis prevalence setting. Trop Doct. 2012 Oct;42(4):217-8.
Date:
2012-10-01
Journal:
Tropical Doctor
Content:
Authors:
Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L; the International HIV-Associated Opportunistic Pneumonias (IHOP) Study.
, Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L; the International HIV-Associated Opportunistic Pneumonias (IHOP) Study. Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections. Respirology. 2014 Apr;19(3):382-8.
Date:
2014-01-26
Journal:
Respirology..
Content:
Authors:
Sanya RE, Kirenga BJ, Worodria W, Okot-Nwang M.
, Sanya RE, Kirenga BJ, Worodria W, Okot-Nwang M. Risk factors for asthma exacerbation in patients presenting to an emergency unit of a national referral hospital in Kampala, Uganda. Afr Health Sci. 2014 Sep;14(3):707-15. doi: 10.4314/ahs.v14i3.29.
Date:
2014-09-04
Journal:
Africa Health Sciences.
Content:
Authors:
Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A.
, Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. J Clin Microbiol. 2013 Jun;51(6):1774-8.
Date:
2013-04-03
Journal:
Journal of Clinical Microbiology
Content:
Authors:
Yoo SD, Cattamanchi A, den Boon S, Worodria W, Kisembo H, Huang L, Davis JL.
, Respirology. 2011 Jul;16(5):836-41.
Date:
2011-07-01
Journal:
Respirology
Content:
Authors:
Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ.
, Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ. A Multilocus Microsatellite Genotyping Array to Investigate the Genetic Epidemiology of Pneumocystis jirovecii. J Clin Microbiol. 2014. 52(5):1391-9
Date:
2014-02-12
Journal:
Journal of Clinical Microbiology
Content:
Authors:
Manabe YC, Worodria W, Cobelens F; PROMPT Study Group.
, Int J Tuberc Lung Dis. 2012 Feb;16(2):280
Date:
2012-02-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Authors:
Acuña-Villaorduña C, Ayakaka I, Dryden-Peterson S, Nakubulwa S, Worodria W, Reilly N, Hosford J, Fennelly KP, Okwera A, Jones-López EC.
, Acuña-Villaorduña C, Ayakaka I, Dryden-Peterson S, Nakubulwa S, Worodria W, Reilly N, Hosford J, Fennelly KP, Okwera A, Jones-López EC. High Mortality Associated with Retreatment of Tuberculosis in a Clinic in Kampala, Uganda: A Retrospective Study. Am J Trop Med Hyg. 2015 May 4. pii: 14-0810
Date:
2015-05-04
Journal:
American Journal of Tropical Medicine and Hygiene
Content:
Authors:
Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL.
, Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL. Sputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda. PLoS One. 2017 Jul 7;12(7):e0180572. doi: 10.1371/journal.pone.0180572. eCollection 2017. PMID:28686705
Date:
2017-07-20
Journal:
PLoS One
Content:
Authors:
Worodria W, Ssempijja V, Hanrahan C, Ssegonja R, Muhofwa A, Mazapkwe D, Mayanja-Kizza H, Reynolds SJ, Colebunders R, Manabe YC.
, Worodria W, Ssempijja V, Hanrahan C, Ssegonja R, Muhofwa A, Mazapkwe D, Mayanja-Kizza H, Reynolds SJ, Colebunders R, Manabe YC. Opportunistic diseases diminish the clinical benefit of immediate antiretroviral therapy in HIV-tuberculosis co-infected adults with low CD4+ cell counts. AIDS. 2018 Sep 24;32(15):2141-2149. doi: 10.1097/QAD.0000000000001941. PMID: 30005014
Date:
2018-09-24
Journal:
AIDS
Content:
Authors:
Katagira W, Walter ND, den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL
, Katagira W, Walter ND, den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL.Empiric TB treatment of severely ill patients with HIV and presumed pulmonary TB improves survival. J Acquir Immune Defic Syndr. 2016 Feb 24. PMID: 26918546
Date:
2016-02-24
Journal:
Journal of Acquired Immune Deficiency Syndrome
Content:
Authors:
Worodria, W, Cattamanchi, A, Davis, JL, den Boon, S, Yoo, S, Joloba, M, Huang, L, and Kato-Maeda, M.
, PLoS One. 2011;6(11):e27017.
Date:
2011-11-04
Journal:
PLoS One
Content:
Authors:
Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK.
, Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK. Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients. J Infect Dis. 2016 Oct 15; 214(8):1205-11. doi: 10.1093/infdis/jiw364. Epub 2016 Aug 17.
Date:
2016-10-15
Journal:
Journal of Infectious Diseases. .
Content:
Authors:
Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV.
, Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV. Immune Response and Mortality Risk Relate to Distinct Lung Microbiomes in HIV-Pneumonia Patients. Am J Respir Crit Care Med. 2016 Jul 22. PMID: 27447987
Date:
2016-07-22
Journal:
American Journal of Respiratory and Critical Care Medicine
Content:
Authors:
Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L
, Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group. Antigen-Specific Interferon-Gamma Responses and Innate Cytokine Balance in TB-IRIS.PLoS One. 2014 Nov 21;9(11):e113101. doi: 10.1371/journal.pone.0113101.
Date:
2014-11-21
Journal:
PLoS One.
Content:
Authors:
Worodria W, Menten J, Massinga-Loembe M, Mazakpwe D, Bagenda D, Koole O, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R; the TB-IRIS Study Group.
, Antivir Ther. 2012;17(5):841-8.
Date:
2012-04-27
Journal:
Antiviral Therapy
Content:
Authors:
Conesa-Botella A, Goovaerts O, Massinga-Loembé M, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Colebunders R, Kestens L; TB IRIS Study Group.
, Conesa-Botella A, Goovaerts O, Massinga-Loembé M, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Colebunders R, Kestens L; TB IRIS Study Group. Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis. Int J Tuberc Lung Dis. 2012 Nov;16(11):1517-21.
Date:
2012-11-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content: